DNA Tumor Viruses: Oncogenic Mechanisms / Edition 1

by Giuseppe Barbanti-Brodano, Mauro Bendinelli, Herman Friedman

Overview

DNA tumor viruses have long been useful experimental models of carcinogenesis and have elucidated several important mechanisms of cell transformation. Research in recent years has shown that human tumors have a multifactorial nature and that some DNA tumor viruses may playa key role in their etiology. The aim of this book is to assess our knowledge of DNA tumor viruses by reviewing animal models, mechanisms of transformation, association with human tumors, and possi­ bilities of prevention and control by vaccination. Animal models of tumor virology have contributed significantly to our understanding of the epidemiology and pathogenesis of virus-induced tumors. Bovine papillomaviruses induce papillomas in the intestine of cattle. The papillomas undergo a transition to carcinomas in cows feeding on bracken fern, which pro­ duces a toxin with radiomimetic and immunosuppressive functions. This example of cooperation between a virus and chemical carcinogens parallels the cooperative role of human papillomaviruses (HPVs) and herpes simplex virus type 2 (HSV-2) with environmental carcinogens in the pathogenesis of cervical cancer. Likewise, hepaarcinomas appearing in woodchucks chronically infected by woodchuck hepatitis virus (WIN) provide strong support for the relationship between hepatitis B virus (HBV) infection and human hepaellular carcinoma. Also, the fact that WIN DNA integrates closely to cellular oncogenes suggests a possible molecular mechanism for the tumorigenesis induced by HBV.

Product Details

ISBN-13:	9780306451515
Publisher:	Springer US
Publication date:	01/31/1996
Series:	Infectious Agents and Pathogenesis
Edition description:	1995
Pages:	428
Product dimensions:	5.98(w) x 9.02(h) x 0.35(d)

About the Author

Barbanti-Brodano, Giuseppe (Univ of Ferrara, Italy); Bendinelli, Mauro (Univ of Pisa); Friedman, Herman (Univ of South Florida)

The contributors represent the specialties of microbiology, immunology, pathology, virology, and experimental oncology. Most are from universities and research institutions in the U.S., Italy, Germany, France, and the U.K. Institutions prominently represented include Univ of Ferrara, Centro di Referimento Oncologico in Italy, Phillipps-Universitat in Marburg, Germany, and National Cancer Institute.

Table of Contents

1. The Hamster Polyomavirus.- 2. Simian Virus 40 Large T Antigen Induces Chromosome Damage That Precedes and Coincides with Complete Neoplastic Transformation.- 3. Transformation by Polyomaviruses: Role of Tumor Suppressor Proteins.- 4. Association of BK and JC Human Polyomaviruses and SV40 with Human Tumors.- 5. Association of Simian Virus 40 with Rodent and Human Mesotheliomas.- 6. Immortalization of Keratinocytes by Human Papillomaviruses.- 7. Cooperation between Bovine Papillomaviruses and Dietary Carcinogens in Cancers of Cattle.- 8. Papillomaviruses as Promoting Agents in Human Epithelial Tumors.- 9. Vaccines against Human Papillomaviruses and Associated Tumors.- 10. The Complex Role of Hepatitis B Virus in Human Hepaarcinogenesis.- 11. Transformation and Tumorigenesis Mediated by the Adenovirus E1A and E1B Oncogenes.- 12. Current Developments in the Molecular Biology of Marek’s Disease Virus.- 13. Oncogenic Transformation of T Cells by Herpesvirus saimiri.- 14. Transformation and Mutagenic Effects Induced by Herpes Simplex Virus Types 1 and 2.- 15. Herpes Simplex Virus as a Cooperating Agent in Human Genital Carcinogenesis.- 16. Human Cytomegalovirus: Aspects of Viral Morphogenesis and of Processing and Transport of Viral Glycoproteins.- 17. Association of Human Herpesvirus 6 with Human Tumors.- 18. Molecular Mechanisms of Transformation by Epstein-Barr Virus.- 19. Epstein-Barr Virus: Mechanisms of Oncogenesis.- 20. Association of Epstein-Barr Virus with Hodgkin’s Disease.- 21. The Development of Epstein-Barr Virus Vaccines.

Editorial Reviews

Assesses the current knowledge of dna tumor viruses by reviewing animal models, mechanisms of transformation, association with human tumors, and possibilities of prevention and control by vaccination. Among the topics, two animal herpesviruses inducing lymphoproliferative diseases, Marek's disease virus and Herpesvirus saimiri, are presented as models of lymphomas associated with human herpesviruses, Epstein-Barr virus, and human herpesvirus 6; and two chapters are devoted to humoral and cell-mediated immunity to human papillomaviruses and Epstein-Barr virus in relation to vaccine design and other possibilities of immunologic control of the associated tumors. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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