Down Syndrome and Alzheimer's Disease

by Vee Prasher

Overview

This is the first book in the field to address the underlying biological abnormalities of Dementia in Alzheimer’s Disease (DAD) in people with Down syndrome. It brings together research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer’s disease in older adults with Down syndrome. Down Syndrome and Alzheimer’s Disease presents vital information to medical professionals who provide clinical care to people with Alzheimer’s disease and Down syndrome. It will also be of great benefit to researchers with an interest in Alzheimer’s disease and Down syndrome and academics researching ageing issues in people with Down Syndrome. It complements Alzheimer's Disease and Dementia in Down Syndrome and Intellectual Disabilities by the same author.

Product Details

ISBN-13:	9781315345383
Publisher:	CRC Press
Publication date:	12/14/2018
Sold by:	Barnes & Noble
Format:	eBook
Pages:	200
File size:	2 MB

About the Author

Vee Prasher

Table of Contents

Overview of Alzheimer’s disease in Down syndrome. Neuropathology of Alzheimer’s disease in Down syndrome. Genetics, Alzheimer’s disease and Down syndrome. Amyloid beta and tau Proteins in Alzheimer’s disease and Down syndrome. Down syndrome, dementia, and superoxide dismutase. Macrocytosis: a peripheral marker for dementia in Alzheimer’s disease in adults with Down syndrome? Thyroid function, dementia and Down syndrome. Neurophysiological changes associated with dementia in Down syndrome. Neuroimaging studies of persons with Down syndrome. Concluding remarks

Editorial Reviews

Reviewer: Michael Schrift, DO (University of Washington School of Medicine)
Description: This excellent and interesting book covers the underlying neurobiological abnormalities in patients who have Alzheimer disease with Down syndrome. The diagnosis and management of patients with neurodevelopmental disorders is quite challenging as is the diverse literature on these two unfortunate disorders. This unique book synthesizes the most recent research on the overlap of these common problems. Written and edited by clinician-researchers in the field, the book is a welcome contribution to the neuropsychiatric literature.
Purpose: The purpose of the book is "to bring together in one place recent research findings relating to the neuropathology, genetics, blood markers, and neurophysiological aspects of Alzheimer's disease in older adults with Down syndrome." The editor notes that this is the first book to address the underlying neurobiology contributing to the clinical psychopathology of Alzheimer dementia in Down syndrome patients. Indeed, the editor and chapter authors have produced an exceptionable book.
Audience: The intended audience includes researchers and clinicians working with people with intellectual disability.
Features: All the important aspects of Alzheimer disease in Down syndrome are covered, including clinical features, neuropathology, genetics, amyloid beta and tau in the combined disorder, superoxide dismutase, neurophysiologic changes, thyroid disorders, and brain imaging.
Assessment: This is a unique, first-rate book covering a needed clinical focus: dementia in Down syndrome. Any clinician who is involved in the care of patients with neurodevelopmental disorders would benefit from reading this important book.

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