Drug Discovery and Development / Edition 1

by Michael Williams, Jeffrey B. Malick

Overview

The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar- maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera- peutic entities, as evidenced by Sir James Black's H -receptor an- 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex- pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy- chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de- velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.

Product Details

ISBN-13:	9780896031081
Publisher:	Springer-Verlag New York, LLC
Publication date:	08/27/1987
Series:	Contemporary Biomedicine Series
Edition description:	1987
Pages:	448
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

Overview.- Drug Discovery and Development: Reflections and Projections.- Compound Discovery.- Drug Design.- Computer-Based Approaches to Drug Design.- Use of Intact Tissue Preparations in the Drug Discovery Process.- Neuropsychopharmacological Drug Development.- Biochemical Approaches for Evaluating Drug—Receptor Interactions.- Drug Discovery at the Enzyme Level.- EEG, EEG Power Spectra, and Behavioral Correlates of Opioids and Other Psychoactive Agents.- Immunopharmacological Approaches to Drug Development.- Toxicological Evaluation and Clinical Aspects.- Toxicological Evaluation of Drugs.- Drug Delivery Systems.- Clinical Evaluation of Drug Candidates.- Therapeutic Entities—From Discovery to Human Use.- Cimetidine and Other Histamine H2-Receptor Antagonists.- Atypical Psychotropic Agents: Trazodone and Buspirone.- Calcium Channel Antagonists.