Drug Resistance / Edition 1

by William N. Hait

Overview

Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time.
In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.

Product Details

ISBN-13:	9781461285403
Publisher:	Springer US
Publication date:	09/16/2011
Series:	Cancer Treatment and Research , #87
Edition description:	Softcover reprint of the original 1st ed. 1996
Pages:	418
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)

About the Author

Hait, William N., MD, PhD (Univ of Medicine and Dentistry of New Jersey)

The contributors represent the specialties of oncology, pharmacology, and molecular biology. Most are from academic medical centers, cancer institutes, and laboratories in the U.S. Institutions prominently represented include Case Western Reserve Univ, Georgetown, Yale, Univ of Medicine and Dentistry of New Jersey, Fox Chase Cancer Center, and NCI.

Table of Contents

I. Membrane Transport Mechanism.- 1. P-Glycoprotein-Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal.- 2. Multidrug Resistance Associated with Overexpression of MRP.- II. Resistance to Alkylating Agents.- 3. Mechanisms of Resistance to Alkylating Agents.- 4. Glutathione S-Transferases.- 5. Role of DNA Repair in Resistance to Drugs that Alkylate O6 of Guanine.- III. Resistance to Microtubule Active Drugs.- 6. Paclitaxel (Taxol®): Mechanisms of Resistance.- IV. Resistance to Antimetabolites.- 7. Mechanisms of Clinical Resistance to 5-Fluorouracil Chemotherapy.- 8. Antifolates: Current Developments.- 9. Human Immunodeficiency Virus Replication in the Presence of Antiretroviral Drugs: Analogies to Antineoplastic Drug Resistance.- 10. Cellular Resistance to Topoisomerase Poisons.- VI. Resistance to Endocrine Therapies.- 11. Acquisition of an Antiestrogen Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular Mechanisms.- 12. Androgen Receptor Mutations in Prostate Cancer.- VII. Resistance to Retinoids.- 13. Retinoids in Clinical Cancer Therapy.- VIII. Novel Mechanisms and Approaches.- 14. Apoptosis and Cancer Chemotherapy.- 15. Interaction of Chemotherapy and Biological Response Modifiers in the Treatment of Melanoma.- 16. Multifunctional Modulators of Drug Resistance.

Editorial Reviews

3 Stars from Doody

The leading researchers in the field provide monographs on the full spectrum of mechanisms by which cancer cells become resistant to therapy. The discussion is not limited to resistance to cytotoxic agents; reviews of androgen and antiestrogen resistance, retinoids, and immunotherapy provide a broad perspective for researchers who often concentrate only on a single aspect of resistance. The editor fulfills his stated goal of providing an in-depth review of the full spectrum of drug resistance for scientists with a research interest in the field. These reviews also provide an excellent overview for scientists who would like to enter the field. The authors generally present current understanding of resistance mechanisms, rather than discussing experimental evidence, but provide ample references to the primary literature. In general, the authors expect the reader to be familiar with biochemistry and molecular biology. The individual reviews have extensive and up-to-date reference lists. The limited number of illustrations are well-chosen to demonstrate the basic principles under discussion. Each review stands alone; as a result there is occasionally duplication among the discussions. This collection of reviews, written by active scientists in each field, is welcome for the broad perspective it offers on the challenging ways in which cancer cells become resistant to cytotoxic, hormonal and immune therapies. It is well suited as an entree into the field for young scientists and as a reminder to experts of the breadth and interrelationships of resistance to different kinds of drugs.

Margaret S. Dordal

Reviewer: Margaret S. Dordal, MD, PhD (Northwestern University Feinberg School of Medicine)
Description: The leading researchers in the field provide monographs on the full spectrum of mechanisms by which cancer cells become resistant to therapy. The discussion is not limited to resistance to cytotoxic agents; reviews of androgen and antiestrogen resistance, retinoids, and immunotherapy provide a broad perspective for researchers who often concentrate only on a single aspect of resistance.
Purpose: The editor fulfills his stated goal of providing an in-depth review of the full spectrum of drug resistance for scientists with a research interest in the field.
Audience: These reviews also provide an excellent overview for scientists who would like to enter the field. The authors generally present current understanding of resistance mechanisms, rather than discussing experimental evidence, but provide ample references to the primary literature. In general, the authors expect the reader to be familiar with biochemistry and molecular biology.
Features: The individual reviews have extensive and up-to-date reference lists. The limited number of illustrations are well-chosen to demonstrate the basic principles under discussion. Each review stands alone; as a result there is occasionally duplication among the discussions.
Assessment: This collection of reviews, written by active scientists in each field, is welcome for the broad perspective it offers on the challenging ways in which cancer cells become resistant to cytotoxic, hormonal and immune therapies. It is well suited as an entree into the field for young scientists and as a reminder to experts of the breadth and interrelationships of resistance to different kinds of drugs.

Doody's Review Service