Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition

by Rajesh K. Naz (Editor)

Overview

There is great concern regarding the reproductive and health hazards of endocrine disruptors. Research indicates that men are experiencing declining fertility and an increased incidence of prostate cancer, while women are dealing with increased infertility, early menopause, and breast cancer. As new research reveals the previously unknown risks of

Product Details

ISBN-13:	9781000611649
Publisher:	CRC Press
Publication date:	11/29/2004
Sold by:	Barnes & Noble
Format:	eBook
Pages:	464
File size:	5 MB

About the Author

Rajesh K. Naz, Ph.D. , is Professor of Obstetrics and Gynecology, and Physiology, as well as Director of the Division of Research at the Medical College of Ohio in Toledo. Dr. Naz received his B.S. and M.S. degrees in biochemistry in 1973 and 1975, respectively. He received his Ph.D. in immunology in 1980 from the prestigious All India Institute of Medical Sciences in New Delhi, under the guidance of the renowned reproductive endocrinologist G.P. Talwar. In 1984, following postdoctoral work in reproductive immunology at the University of Michigan Medical School in Ann Arbor and then at the Oregon Regional Primate Research Center at Beaverton, he was appointed Assistant Professor and Director of the In Vitro Fertilization and Andrology Laboratories at the George Washington University in Washington, D.C. He joined the Albert Einstein College of Medicine in 1987 and was promoted to Associate Professor and Director of Research in 1989. He moved to the Medical College of Ohio in 1996. Dr. Naz is a member of the Society for Gynecologic Investigation, American Society of Biochemistry and Molecular Biology, American Society for the Immunology of Reproduction, International Society for the Immunology of Reproduction, American Society of Reproductive Medicine, American Society of Andrology, Society for the Study of Reproduction, Endocrine Society, American Association for the Advancement of Science, and the New York Academy of Sciences. Dr. Naz has lectured on reproductive immunology at numerous national and international symposia and at various conferences. He has received many prestigious awards and honors, and is a scientific reviewer for various grant proposals and research manuscripts for journals. He also is the member of the editorial boards of seven journals including Biology of Reproduction and Archives of Andrology , and is the associate editor of Frontiers in BioScience , Human Reproduction , and Molecular Reproduction and Development. He has served in several study sections of the National Institutes of Health, including chairman of the Special Emphasis Panel SBIR Study Section. He has also served as a regular member of NIH’s Reproductive Endocrinology Study Section. Dr. Naz has published over 160 articles in scientific journals, as well as authoring and editing four books: Immunology of Reproduction , Male Reproductive Medicine: From Spermatogenesis to Sperm Function and Modulation of Fertility , Prostate: Basic and Clinical Aspects , and Endocrine Disruptors: Effects on Male and Female Reproductive Systems . His current interests include the molecular mechanisms underlying endocrinologic and immunologic control of fertility and infertility, and benign prostate hyperplasia (BPH) and prostate cancer in humans. He is especially interested in how the endocrine disruptors and environmental toxins can modify the male and female reproductive systems.

Table of Contents

Effect on the Female Reproductive System. Disruption of Nongenomic Steroid Actions on Gametes and Serotonergic Pathways Controlling Reproductive Neuroendocrine Function by Environmental Chemicals. Developmental and Reproductive Abnormalities Associated with Environmental Estrogens: Diethylstilbestrol (DES) as an Example. Ovotoxic Environmental Chemicals: Indirect Endocrine Disruptors. p,p'-DDE and HCB: Mechanisms of Toxicity to Fetal and Embryonic Mammalian Cells. Dietary Phytoestrogens. Estrogens, Xenoestrogens and the Development of Neoplasms. Molecular Mechanisms of Endocrine Disruption in Estrogen Dependent Processes. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Environmental Antiestrogens: Characterization and Mechanism of Action. Effect on the Male Reproductive System. Endocrine Disruptors and Male Infertility. Environmental Androgens and Antiandrogens: An Expanding Chemical Universe. Endocrine Disruptors and Male Sexual Dysfunction. Prostate Development: Mechanisms for Opposite Effects of Low and High Doses of Estrogenic Chemicals. Metal Ions as Endocrine Disruptors: Implications for Prostate Cancer.

Editorial Reviews

5 Stars! from Doody

Examines the epidemiology and etiology of environmental toxicants, also known as hormone impostors, many of which act as reproductive toxicants that cause fertility problems. The 12 contributions address issues such as declining global fertility, rising incidences of breast and prostate cancer, and the wide variety of toxic affects that the synthetic chemicals exert on the gonads, fertility, and sexual and reproductive function. Individual topics include: how diethylstilbestrol and environmental estrogens influence the developing female reproductive system; dietary phytoestrogens; endocrine disrupters and male infertility; and the role of natural and man made estrogens in prostate development. Annotation c. by Book News, Inc., Portland, Or.

Booknews

Reviewer: John T. Pierce, MBBS (MD) PhD(Navy Environmental Health Center)
Description: This book on endocrine disruptors is divided into two sections. The first treats the effects of environmental toxicants on the female reproductive system, with special emphasis on effects and mechanisms. It contains chapters discussing both female endocrinology and carcinogenesis. The second section deals with the effects of endocrine disruption by environmental toxicants on the male reproductive systems, focusing on male fertility and development of benign prostate hyperplasia and prostate cancer.
Purpose: In the five years since the appearance of the first edition, numerous advances have emerged in both the basic science and the clinical issues pertinent to endocrine disruptors. The editor also notes concern among the scientific community, policy makers, and the general public regarding reproductive and health hazards of endocrine-disrupting environmental chemicals.
Audience: The editor provides clues that that the second edition will be useful to endocrine reproductive biologists and to associated clinical scientists. Actually, some of the more molecular and embryology oriented chapters are quite good, possibly attracting interest across an even broader range of individuals interested in reproductive biology. Furthermore, although the book is written at a high level, I believe it will be referenced by policy makers and the general public, who may sometimes have to rely upon basic and clinical scientists for further interpretation of key words.
Features: The editor argues that the second edition is a model source of recent, updated, vital and viable scientific information on endocrine disruption. Based upon the distinguished panel of authors, I tend to agree. In fairness, the book has been kept to a reasonable size, about 450 pages. Chapter references extend to 100-150 entries and are current and significant. I was pleased I was able to retrieve chemical names or pathologic terms using the index.
Assessment: Certainly, the press of new scientific articles since the book's original publication in 1999 demands a second edition. The editor indicates the book is a somewhat unique entity. There are probably more encyclopedic references on the results of endocrine disruption, but they do not do as much to explain the molecular mechanisms of these phenomena.

Doody's Review Service