Environmental Stressors in Health and Disease / Edition 1

by Jürgen Fuchs

Overview

This volume illustrates the impact of environmental oxidants on the tissues of the eyes, lungs and skin, as well as on the immune system - highlighting common illnesses, injuries and pathologies induced by pro-oxidant environmental xenobiotics such as inflammation, immune response, signal transduction, regulation of gene expression, and carcinogenesis. It provides clinical presentations and discusses the effects of environmental oxidants on target organs.

Product Details

ISBN-13:	9780824705305
Publisher:	Taylor & Francis
Publication date:	07/20/2001
Series:	Oxidative Stress and Disease Series , #7
Edition description:	New Edition
Pages:	528
Product dimensions:	6.88(w) x 9.69(h) x (d)

About the Author

Jurgen Fuchs is Research Associate and clinical faculty member, Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt, Germany. The author of approximately 200 published articles and the coeditor of Lipoic Acid in Health and Disease, Oxidative Stress in Dermatology, Vitamin C in Health and Disease, and Vitamin E in Health and Disease (all titles, Marcel Dekker, Inc.), he received the Ph.D. degree (1985) in biology and the M.D. degree (1986) from the University of Frankfurt, Germany. Lester Packer is an Adjunct Professor of Molecular Pharmacology and Toxicology at the University of Southern California School of Pharmacy, Los Angeles. The recipient of the Optolind Skin Research Prize 2000, he is the author, coauthor, editor, or coeditor of over 700 journal articles, book chapters, and books, including Antioxidants in Diabetes Management, Biothiols in Health and Disease, Flavonoids in Health and Disease, Free Radicals in Brain Pathophysiology, the Handbook of Antioxidants, the Handbook of Synthetic Antioxidants, Lipoic Acid in Health and Disease, Nutraceuticals in Health and Disease Prevention, Oxidative Stress in Dermatology, Redox Regulation in Cell Signaling and Its Clinical Application, Retinoids, Understanding the Process of Aging, Vitamin C in Health and Disease, and Vitamin E in Health and Disease (all titles, Marcel Dekker, Inc.). Dr. Packer received the B.S. (1951) and M.S. (1952) degrees in biology and chemistry from Brooklyn College, New York, and the Ph.D. degree (1956) in microbiology and biochemistry from Yale University, New Haven, Connecticut.

Table of Contents

Series Introduction, Preface Contributors, I. Molecular and Cellular Aspects of Prooxidant Environmental Xenobiotics, 1. Free Radical Reactions in Human Disease, 2. Radicals and Inflammation: Mediators and Modulators, 3. Autoimmunity Caused by Oxidizing Foreign Compounds, 4. Role of Oxidative Stress in Chemical Carcinogenesis, 5. Proposed Mechanisms of Arsenic Toxicity Carcinogenesis, 6. Redox Regulation of Gene Expression and Transcription Factors in Response to Environmental Oxidants, II. Target Organs of Environmental Oxidants: Lung, 7. Cigarette Smoking and Pulmonary Oxidative Damage, 8. Health Effects of Diesel Exhaust and Diesel Exhaust Particles, 9. The Role of Free Radicals in Asbestos- and Silica-Induced Fibrotic Lung Diseases, 10. Reactive Oxygen Species and Silica Induced Carcinogenesis, 11. Atmospheric Oxidants and Respiratory Tract Surfaces, III. Target Organs of Environmental Oxidants: Skin, 12. Redox Modulation and Oxidative Stress in Dermatotoxicology, 13. Dermatotoxicology of Environmental and Occupational Chemical Hazards: Agents and Action, 14. Photooxidative Stress in Skin and Regulation of Gene Expression, 15. Ozone Stress in the Skin Barrier, 16. Immunotoxicity of Environmental Agents in the Skin, IV. Target Organs of Environmental Oxidants: Eye, 17. Environmental Stressors and the Eye, 18. Free Radicals and Aging of Anterior Segment Tissues of the Eye, 19. The Role of Ocular Free Radicals in Age Related Macular Degeneration, 20. Nutritional Influences on Risk for Cataract, Index