Fusion Genes And Cancer

by Ajaikumar B Kunnumakkara, Ganesan Padmavathi, Nand Kishor Roy

Overview

Development of cancer, a dreadful disease of mankind, is a multi-stage process involving numerous molecular alterations at both genomic and proteomic levels. Immense research for the past several decades in the field of cancer identified many such mutations and their role in carcinogenesis. Concept of 'fusion genes' seeded way back in 20th century has now grown into a new field of cancer research. However, there is a lack of knowledge among scientists about these fusion genes and their importance in cancer, which can be mainly attributed to unavailability of a comprehensive book on this topic. Therefore, this book is first of its kind and aims at giving a detailed idea on the formation of gene fusions and their importance in the development and progression of cancer; techniques to identify novel gene fusions; and therapeutics available to target various fusion proteins and their impact in cancer therapy by compiling the information from the literature available till date.

Product Details

ISBN-13:	9789813200937
Publisher:	World Scientific Publishing Company, Incorporated
Publication date:	06/01/2017
Pages:	432
Product dimensions:	6.20(w) x 9.00(h) x 0.90(d)

Table of Contents

Preface vii

About the Editors xi

List of Contributors xiii

1 Cancer - An Overview and Molecular Alterations in Cancer Nand K. Roy Devivasha Bordoloi Javadi Monisha Anand Anip Ganesan Padmavathi Ajaikumar B. Kunnumakkara 1

2 Basic Concepts of Fusion Genes and Their Classification Ganesan Padmavathi Nand K. Roy Devivasha Bordoloi Javadi Monisha Ajaikumar B. Kunnumakkara 17

3 Techniques to Identify Novel Fusion Genes and to Detect Known Fusion Genes Nand K. Roy Ganesan Padmavathi Devivasha Bordoloi Ajaikumar B. Kunnumakkara 59

4 The Receptor Tyrosine Kinase ALK - Its Fusion Partners and Their Implication in Various Cancers Ganesan Padmavathi Krishan Kumar Thakur Anand Anip Devivasha Bordoloi Ajaikumar B. Kunnumakkara 81

5 Role of BCR-ABL Fusion Kinase in the Development of Leukemia Ganesan Padmavathi Kishore Banik Nand K. Roy Javadi Monisha Ajaikumar B. Kunnumakkara 111

6 BRD4-NUT Fusion Oncoprotein and Its Significance in the Initiation and Progression of NUT Midline Carcinoma Ganesan Padmavathi Devivasha Bordoloi Kishore Banik Ajaikumar B. Kunnumakkara 129

7 Importance of CBFB-MYH11 - A Chimeric Transcriptional Regulator in Leukemia Ganesan Padmavathi Choudhary Harsha Devivasha Bordoloi Krishan Kumar Thakur Ajaikumar B. Kunnumakkara 137

8 Rearrangements Involving ETS Family of Genes and Their Role in Different Cancers Ganesan Padmavathi Javadi Monisha Kishore Banik Choudhary Harsha Devivasha Bordoloi Ajaikumar B. Kunnumakkara 147

9 Translocation of FET Family Members with Various Partner Genes and Their Role in Cancer Development Ganesan Padmavathi Devivasha Bordoloi Anand Anip Krishan Kumar Thakur Ajaikumar B. Kunnumakkara 163

10 Translocations of FGF and FGFR Proteins and Their Effect in Cancer Ganesan Padmavathi Javadi Monisha Choudhary Harsha Ajaikumar B. Kunnumakkara 189

11 IG-MYC and Its Implication in Cancer Ganesan Padmavathi Kishore Banik Krishan Kumar Thakur Ajaikumar B. Kunnumakkara 201

12 Chimeric RAF Kinases in the Development of Cancer Ganesan Padmavathi Kishore Banik Devivasha Bordoloi Choudhary Harsha Ajaikumar B. Kunnumakkara 209

13 Mucoepidermoid Carcinoma (MEC) and Associated MAML2 Fusion Genes Ganesan Padmavathi Choudhary Harsha Devivasha Bordoloi Kishore Banik Ajaikumar B. Kunnumakkara 221

14 Mixed Lineage Leukemia/AF9 Fusion and Associated Leukemia Ganesan Padmavathi Choudhary Harsha Ajaikumar B. Kunnumakkara 231

15 MYB-NFIB Fusion Gene - Hallmark of Adenoid Cystic Carcinoma (ACC) Ganesan Padmavathi Krishan Kumar Thakur Ajaikumar B. Kunnumakkara 245

16 Translocations Involving PAX Family Genes and Their Effect in Cancer Ganesan Padmavathi Krishan Kumar Thakur Ajaikumar B. Kunnumakkara 253

17 Retinoic Acid Receptor Alpha (RARa) Fusion Genes in Leukemia Ganesan Padmavathi Javadi Monisha Anand Anip Krishan Kumar Thakur Ajaikumar B. Kunnumakkara 271

18 RET-PTC Translocations and Thyroid Malignancies Ganesan Padmavathi Devivasha Bordoloi Anand Anip Choudhary Harsha Ajaikumar B. Kunnumakkara 287

19 RUNX1 or AML1 Fusion Genes in Leukemia and Other Cancers Ganesan Padmavathi Javadi Monisha Kishore Banik Choudhary Harsha Devivasha Bordoloi Ajaikumar B. Kunnumakkara 297

20 Recently Discovered Fusion Genes and Their Implications in Cancer Ganesan Padmavathi Devivasha Bordoloi Javadi Monisha Nand K. Roy Choudhary Harsha Ajaikumar B. Kunnumakkara 315

21 Targeting Fusion Genes for Cancer Therapy Nand K. Roy Devivasha. Bordoloi Ganesan Padmavathi Ajaikumar B. Kunnumakkara 349

Index 373