Table of Contents
List of Contributors v
Preface vii
Section I Overview
1 Genetic animal models for schizophrenia: advantages and limitations of genetic manipulation in drosophila, zebrafish, rodents, and primates Akir Sawa 3
Section II Novel Techniques to Generate Genetic Models
2 Animal models for schizophrenia via in utero gene transfer: understanding roles for genetic susceptibility factors in brain development Atsushi Kamiya 9
3 Gene manipulation with of stereotaxic viral infection for psychiatric research: Spatiotemporal components for schizophrenia Anupamaa J. Seshadri Akiko Hayashi-Takagi 17
4 ENU-induced mutant mice for a next-generation gene-targeting system Yoichi Gondo Ryutaro Fukumura 29
5 Inducible and conditional transgenic mouse models of schizophrenia Mikhail V. Pletnikov 35
Section III Representative Models
6 NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia Amy J. Ramsey 51
7 Modeling excess striatal D2 receptors in mice Christoph Kellendonk 59
8 Differential function of phosphodiesterase families in the brain: gaining insights through the use of genetically modified animals Michele P. Kelly Nicholas J. Brandon 67
9 Gene models of schizophrenia: DISCI mouse models Hanna Jaaro-Peled 75
10 The sandy (sdy) mouse: a dysbindin-1 mutant relevant to schizophrenia research Konrad Talbot 87
Section IV Other than Rodents
11 Zebrafish: a model system to examine the neurodevelopmental basis of schizophrenia Jill A. Morris 97
12 Modeling schizophrenia in flies Katsuo Furukubo-Tokunaga 107
13 Primate models of schizophrenia: future possibilities Arthur A. Simen Ralph DiLeone Amy F.T. Arnsten117
Subject Index 127
