Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2

by BSc R Martin RN (Editor), PhD Preedy BSc (Editor)

Overview

Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about dementia

Product Details

ISBN-13:	9780128158692
Publisher:	Elsevier Science & Technology Books
Publication date:	08/11/2020
Sold by:	Barnes & Noble
Format:	eBook
Pages:	952
File size:	139 MB
Note:	This product may take a few minutes to download.

About the Author

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Table of Contents

Part I: Genetics, molecular and cellular biology 1. The neuron navigator 2 gene and Alzheimer's diseaseChun Xu, Brenda Bin Su, Stephanie Lozano and Kesheng Wang 2. Interlinking polymorphisms, estrogens, and Alzheimer diseaseLu Hua Chen, Leung Wing Chu and You-Qiang Song 3. Linking EEGs, Alzheimer disease, and the phosphatidylinositol-binding clathrin assembly protein (PICALM) geneNatalya Ponomareva, Tatiana Andreeva, Vitaly Fokin, Sergey Illarioshkin and Evgeny Rogaev 4. CD36 gene polymorphisms and Alzheimer's diseaseOmar Šerý, Nandu Goswami and Vladimir J. Balcar 5. Genetic contributions to sporadic frontotemporal dementiaJessie S. Carr, Daniel W. Sirkis and Jennifer S. Yokoyama 6. Clinical response to cholinesterase inhibitors in dementia: the role of CYP2D6 and APOE genetic polymorphismsLuís Felipe José Ravic de Miranda, Karina Braga Gomes and Paulo Caramelli 7. A1 and A2 purinergic receptor expression in dementiaJ. Mendiola-Precoma, L.C. Berumen, A. Rodríguez-Cruz and G. García-Alcocer 8. Molecular aspects of metallothioneins in dementiasGemma Comes, Anna Escrig, Yasmina Manso, Olaya Fernández-Gayol, Paula Sanchis, Amalia Molinero, Mercedes Giralt, Javier Carrasco and Juan Hidalgo 9. Implication of microRNAs in Alzheimer's disease pathogenesisKatarzyn Marta Zoltowska, Katarzyna Laskowska-Kaszub, Siranjeevi Nagaraj and Urszula Wojda 10. Role of cellular oxidative stress in dementiaGiovanna Galliciotti, Antonella De Jaco, Diego Sepulveda-Falla, Emanuela D'Acunto and Elena Miranda 11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer disease neurodegenerationJuan M. Zolezzi, Paulina Villaseca and Nibaldo C. Inestrosa 12. Wnt signaling and dementiaCarolina Alquezár and Ángeles Martín-Requero 13. Linkage of atypical protein kinase C to Alzheimer diseaseRobert V. Farese and Mini P. Sajan 14. Linking histone deacetylases and phosphodiesterase 5 in novel treatments for Alzheimer's diseaseAna Garcia-Osta and Mar Cuadrado-Tejedor 15. Nuclear factor erythroid 2-related factor 2 in Alzheimer's diseaseKelsey E. Murphy and Joshua J. Park 16. Implications of alpha- and beta-secretase expression and function in Alzheimer's diseaseSven Reinhardt and Kristina Endres 17. Methylation analysis of DNA in Alzheimer's diseaseFabio Coppedè 18. The signalosome malfunctions in age-associated neuropathologiesRicardo Puertas-Avendaño, David Quinto-Alemany, Miriam González-Gómez and Raquel Marin 19. FAM3C in Alzheimer's disease: a risk-related molecule and potential therapeutic targetMasaki Nishimura, Naoki Watanabe, Emi Hibino, Masaki Nakano, Yachiyo Mitsuishi, Lei Liu and Takuma Sugi 20. Amylin and amylin receptors in Alzheimer's diseaseWen Fu and Jack H. Jhamandas 21. Mammalian target of rapamycin complexes: regulation and Alzheimer's diseaseHenry Querfurth and Han-Kyu Lee 22. Mammalian target of rapamycin complexes: protein synthesis and autophagy, Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal dementiaHenry Querfurth and Han-Kyu Lee 23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammationDouglas Gordon Walker Part II: Neurological, physiological and imaging 24. Hippocampal atrophy associated with dementia risk factors and dementiaHiroshi Yao, Yuko Araki, Fumio Yamashita, Makoto Sasaki and Manabu Hashimoto 25. Inflammation and insulin resistance in Alzheimer's disease: partners in crimeYuval Nash and Dan Frenke 26. Brain susceptibility to hypoxia/hypoxemia and metabolic dysfunction in Alzheimer's disease: insights from animal and in vitro modelsVito Antonio Baldassarro, Andrea Bighinati, Michele Sannia, Luciana Giardino and Laura Calzà 27. Neuropeptides and neurolipids: what they are and how they relate to Alzheimer's diseaseIván Manuel, Laura Lombardero, Alberto Llorente-Ovejero and Rafael Rodríguez-Puertas 28.

What People are Saying About This

From the Publisher

Consolidates multiple fields of dementia research to offer comprehensive translational coverage of the neuroscience of dementia, from pathology to therapy