Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews / Edition 1

by Neil Woodford, Alan P. Johnson

Overview

Gazing into crystal balls is beyond the expertise of most scientists. Yet, as we look further into the 21st century, one does not have to be Nostradamus to predict that the current genomics and proteomics "revolution" will have an immense impact on medical bacteriology. This impact is already being re- ized in many academic departments, and although encroachment on routine diagnostic bacteriology, particularly in the hospital setting, is likely to occur at a slower pace, it remains nonetheless inevitable. Therefore, it is important that no one working in bacteriology should find themselves distanced from these fundamental developments. The involvement of all clinical bacteriologists is essential if the significant achievements of genome sequencing and analysis are to be turned into tangible advances, with resulting benefits for patient care and m- agement. It is our hope that Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews will play a part in bringing such a development to fruition. The advances in genomics and proteomics have already given us frequent opportunities to reassess our knowledge and understanding of established b- terial adversaries, and have provided us with the means to identify new foes. The new knowledge gained is enabling us to reconsider, for example, our c- cepts of bacterial pathogenicity, phylogeny and novel targets for antibacterial chemotherapy. These topics, and others, are considered in Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews.

Product Details

ISBN-13:	9781588292186
Publisher:	Springer-Verlag New York, LLC
Publication date:	05/12/2004
Series:	Methods in Molecular Biology , #266
Edition description:	2004
Pages:	398
Product dimensions:	6.10(w) x 9.25(h) x 0.24(d)

Table of Contents

Principles of Bacterial Genomics.- Bacterial Genomes for the Masses.- Public Databases.- Genome Sequencing and Annotation.- Comparative Genomics.- Genome Plasticity.- Exploring and Exploiting Bacterial Proteomes.- Application of Genomics to Diagnostic Bacteriology.- Molecular Diagnostics.- Molecular Diagnostics.- Real-Time PCR.- Microarrays for Bacterial Typing.- Interrogating Bacterial Genomes.- Genomic Approaches to Antibacterial Discovery.- Using the Genome to Understand Pathogenicity.- Identification of Novel Pathogenicity Genes by PCR Signature-Tagged Mutagenesis and Related Technologies.- Discovering New Pathogens.- Exploring the Concept of Clonality in Bacteria.- Bacterial Taxonomics.