Glutamate and Addiction / Edition 1

by Barbara H. Herman

Overview

In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the "glutamate cascade" to determine their roles in various addictive states.

Product Details

ISBN-13:	9781617372346
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/09/2010
Series:	Contemporary Clinical Neuroscience
Edition description:	Softcover reprint of hardcover 1st ed. 2002
Pages:	440
Product dimensions:	7.01(w) x 10.00(h) x 0.28(d)

Table of Contents

I. Introduction: Physiology and Pharmacology of Glutamate.- 1 Molecular Pharmacology and Physiology of Glutamate Receptors.- 2 Pharmacology of Glutamate Receptors.- 3 Glutamate and Neurotoxicity.- 4 Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity.- 5 Role of the NMDA Receptor in Neuronal Apoptosis and HIV-Associated Dementia.- II. Glutamate: Stimulant Drugs of Abuse (Cocaine, Amphetamine, Methamphetamine).- 6 Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned Increases in Locomotor Activity.- 7 Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced Stereotypy and Behavioral Sensitization.- 8 Addiction and Glutamate-Dependent Plasticity.- 9 Glutamate and Dopamine Interactions in the Motive Circuit: Implications for Craving.- 10 Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal Neurons: Implications for Psychostimulant Dependence and Medication.- 11 Glutamate Neurotransmission in the Course of Cocaine Addiction.- 12 Glutamate and the Self-Administration of Psychomotor-Stimulant Drugs.- 13 Roles of Glutamate, Nitric Oxide, Oxidative Stress, and Apoptosis in the Neurotoxicity of Methamphetamine.- 14 Methamphetamine Toxicity: Roles for Glutamate, Oxidative Processes, and Metabolic Stress.- 15 Nitric Oxide-Dependent Processes in the Action of Psychostimulants.- 16 Effects of Novel NMDA/Glycine-Site Antagonists on the Blockade of Cocaine-Induced Behavioral Toxicity in Mice.- 17 Clinical Studies Using NMDA Receptor Antagonists in Cocaine and Opioid Dependence.- 18 The Role of mGluR5 in the Effects of Cocaine: Implications for Medication Development.- III. Glutamate and Opiate Drugs (Heroin) of Abuse.- 19 Role of theGlutamatergic System in Opioid Tolerance and Dependence: Effects of NMDA Receptor Antagonists.- 20 The Role of NMDA Receptors in Opiate Tolerance, Sensitization, and Physical Dependence: A Review of the Research, A Cellular Model, and Implications for the Treatment of Pain and Addiction.- 21 Modification of Conditioned Reward by N-Methyl-D-aspartate Receptor Antagonists.- 22 Morphine Withdrawal as a State of Glutamate Hyperactivity: The Effects of Glutamate Receptor Subtype Ligands on Morphine Withdrawal Symptoms.- IV. Glutamate and Alcohol Abuse and Alcoholism.- 23 Alcohol Actions on Glutamate Receptors.- 24 Glutamate and Alcohol-Induced Neurotoxicity.- 25 Role of Glutamate in Alcohol Withdrawal Kindling.- 26 Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment.- 27 Mechanism of Action of Acamprosate Focusing on the Glutamatergic System.- 28 The NMDA/Nitric Oxide Synthase Cascade in Opioid Analgesia and Tolerance.- 29 Overview of Clinical Studies for Acamprosate.

Editorial Reviews

"Illuminating, authoritative, and forward looking, Glutamate and Addiction clarifies for the first time the relationship between glutamatergic systems and addiction investigations of many of today's emerging therapeutics for addictive disorders." -Biomedicine and Pharmacotherapy

From the Publisher

4 Stars! from Doody

Reviewer: William Miles, MD (Rush University Medical Center)
Description: This book thoroughly reviews the role of the neurotransmitter glutamate in addiction disorders, and presents evidence of the relationship between glutamate and the addiction process.
Purpose: The purpose is to characterize the role of glutaminergic systems in the various addiction disorders. However, the book has a secondary purpose, in that it provides for an extensive review of this neurotransmitter's synthesis, metabolism, and physiology.
Audience: The book is clearly targeted to researchers and clinicians who are interested in, or treat patients with, addiction disorders. It is certainly too detailed for medical students, and may be beyond the scope of most residents as far as the amount of detail provided.
Features: The book begins with a thorough review of the physiology and pharmacology of glutamate, covering such things as its synthesis and receptor-protein gene transcription. The remainder of the book is divided into three sections, each discussing in great detail the role of glutamate in the abuse of stimulants, opiates, and alcohol. These chapters are extraordinary in the amount of detail they provide. There are numerous illustrations scattered throughout, which complement the text rather nicely. Towards the middle of the book is a series of superb color plate illustrations, showing such things as receptor structure and physiologic pathways. Each chapter is followed by an extensive reference list, and an index is provided at the end.
Assessment: The incredibly detailed book will certainly answer any and all questions one may have about the neurotransmitter glutamate and the role it plays in addiction disorders. Although probably too detailed for the average clinician, psychiatrists and others who wish to understand the biology of addiction will find it a useful reference. Certainly addictionologists and researchers in this field will find it an invaluable resource. The superb illustrations and color plates are an added bonus. Overall, this book is an excellent contribution to the field of addiction medicine.

Doody's Review Service