Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

by Raphael Enoque Ferraz de Paiva

Overview

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with NsubN and CsubN donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Product Details

ISBN-13:	9783030131500
Publisher:	Springer International Publishing
Publication date:	12/03/2019
Series:	Springer Theses
Edition description:	Softcover reprint of the original 1st ed. 2018
Pages:	151
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

Au(I)-phosphine series design.- Probing the Protein: Ion Mobility Spectrometry.- Probing Gold: X-ray Absorption Spectroscopy.- Probing Cells: Cytotoxicity Evaluation.- Au(III) series with k²C,N and k²N,N' ligands.- "Dual Probe" X-ray Absorption Spectroscopy.