Grauzone and Completion of Meiosis During Drosophila Oogenesis / Edition 1

by Bin Chen

Overview

Grauzone and Completion of Meiosis During Drosophila Oogenesis describes the work behind a major, award winning discovery: the establishment of a new pathway that specifically regulates the female meiosis, a process essential for sexual reproduction. This book chronicles a new gene mapping method and the cloning and documentation of several types of genes that were proven to have significant influence on the cell cycle. It is of interest to anyone doing work with fruit flies, both graduate students and principal investigators.

Product Details

ISBN-13:	9780792373636
Publisher:	Springer US
Publication date:	05/31/2001
Edition description:	2001
Pages:	80
Product dimensions:	6.10(w) x 9.25(h) x 0.01(d)

About the Author

Bin Chen is a researcher at Stanford University and is the winner of the Larry Sandler Award.

Table of Contents

List of Figures. List of Tables. Preface. Acknowledgements. General Introduction. 1. Female Meiotic Cell Cycle. 2. Genesis and Meiosis in Drosophila Females. 3. Cell Cycle Regulation of Drosophila Female Meiosis. 4. Mutations in Grauzone (Grau) and Cortex (Cort) Block Progression of Drosophila Female Meiosis and Cause Other Defects. 5. Goals and Significance of this Dissertation Research. Mapping of Drosophila Mutations Using Site-Specific Male Recombination. 1. Introduction. 2. Materials and Methods. 3. Results. 4. Discussion. Completion of Meiosis in Drosophila Oocytes Requires Transcriptional Control by Grauzone, a New Zinc Finger Protein. 1. Introduction. 2. Experimental Procedures. 3. Results. 4. Discussion. 5. Acknowledgements. Conclusions and Considerations. 1. Drosophila as a Model to Study Regulation of Female Meiotic Cell Cycle. 2. Grau and Cort are Two Members of a New Pathway that Regulates the Meiotic Cell Cycle Machinery in Drosophila Females. 3. Male Recombination Mapping is a General Method to Map Drosophila Autosomal Mutations. References. Index.

Editorial Reviews

Chen, now at Stanford U., encountered surprises in the course of her doctoral research. The first surprise was the unexpected switch from studying mammalian brains to becoming a (fruit) "fly pusher." Then she unexpectedly found, in cloning , that the and cortex genes in mutant drosophila appear to be members of a new pathway in regulating the course of meiosis. In her introduction, the author explains such terms and gaps in understanding the signaling mechanisms that turn cell division off and on in the female during sexual reproduction. Based on graduate research begun in 1995 at the State U. of New York at Stony Brook. The degree-granting date is not given. Annotation c. Book News, Inc., Portland, OR (booknews.com)