Handbook of Cell-Penetrating Peptides / Edition 2

by Ulo Langel

Overview

Since the first Handbook of Cell-Penetrating Peptides was prepared in 2001, the wealth of new information on the use of these peptides as transport systems has in fact served to confound the field. The constant internal change in the field of cell-penetrating peptides (CPPs) is due to recent research uncovering apparent ambiguities in cellular uptake. There is still neither a common terminology nor a uniform explanation for the penetrative mechanism of cell-penetrating peptides.

In this second edition of the Handbook of Cell-Penetrating Peptides, the authors summarize the current state of the field including recent reevaluations of earlier studies of CPP mechanisms. Beginning with an overview of the classes of peptides and their individual uptake mechanisms, from the earlier lipid models to the more recent endocytotic pathways, the book demonstrates the diversity and the opportunity for these biologically active proteins to serve as future drug leads. The text then covers the use of CPPs in gene modulation, addressing the application of antisense and decoy oligonucleotides, as well as the new avenue of research targeting specific tumors and other tissues-questions that had barely been asked when the first edition was published.

By summarizing the diffuse information regarding CPPs, including the ambiguities and variety of mechanisms, the Handbook of Cell-Penetrating Peptides provides the most solid foundation available from which to expand the potential of this rapidly growing field of medicine.

Product Details

ISBN-13:	9780367390488
Publisher:	Taylor & Francis
Publication date:	09/23/2019
Series:	Pharmacology and Toxicology: Basic and Clinical Aspects
Edition description:	2nd ed.
Pages:	622
Product dimensions:	6.12(w) x 9.19(h) x (d)

About the Author

Ülo Langel

Table of Contents

Classes and Prediction of Cell-Penetrating Peptides, Classes and Prediction of Cell-Penetrating Peptides, Functionality of Shuttling Proteins and Protein-Derived Peptides, Applications of Cell-Penetrating Peptides in Gene Modulation and Protein Transport, Selective Targeting to Tumors and Other Tissues with Cell-Penetrating Peptides: In Vivo Applications, CPP Methods

Editorial Reviews

Reviewer: Grace L Guo, PhD (University of Kansas Medical Center)
Description: This book provides a comprehensive review of cell-penetrating peptides (CPP). It covers the introduction of CPP, the mechanism by which CPP functions, and application of CPP in biological pathway discovery and disease treatment, e.g. tumor therapy. This review will be of great interest to a broad range of scientific readers, including cell biologists and cancer researchers.
Purpose: The purpose is to provide an update in the areas that invoke the most interest in cell-penetrating peptide research.
Audience: The authors target general scientific researchers at both the basic and clinical science level. The authors are leading authorities in the field, which contributes to the success of this excellent review series.
Features: This review covers various aspects of cell-penetrating peptide research, with the focus on CPP introduction and application of CPP in signal transduction and tumor treatment. It provides the up-to-date coverage on the use of CPP in biological research and cancer therapy.
Assessment: This book is very informative for both basic science researchers and physicians, providing an update in many areas fundamental to the research of CPP. It provides an authoritative review on an exciting research topic and is an excellent reference on recent progress in CPP research.

Doody's Review Service