Handbook of Radioembolization: Physics, Biology, Nuclear Medicine, and Imaging / Edition 1

by Alexander S. Pasciak, PhD., Yong Bradley, MD., J. Mark McKinney, MD.

Overview

Radioembolization is a widely used treatment for non-resectable primary and secondary liver cancer. This handbook addresses the radiation biology, physics, nuclear medicine, and imaging for radioembolization using Yttrium-90 (90Y) microspheres, in addition to discussing aspects related to interventional radiology. The contents reflect on and off-label treatment indications, dose-response relationships, treatment-planning, therapy optimization, radiation safety, imaging follow-up and many other facets of this therapy necessary for both novice and advanced users alike.

Product Details

ISBN-13:	9780367874681
Publisher:	CRC Press
Publication date:	12/12/2019
Series:	Imaging in Medical Diagnosis and Therapy
Pages:	348
Product dimensions:	7.00(w) x 10.00(h) x (d)

About the Author

Alexander S. Pasciak, PhD, earned a BS in electrical engineering at the University of Washington, MS in health physics and PhD in nuclear engineering at Texas A&M University. In 2010, Dr. Pasciak completed a 2-year diagnostic medical physics residency at the University of Texas MD Anderson Cancer Center after which he worked for 5 years as a diagnostic medical physicist at the University of Tennessee Medical Center in Knoxville, Tennessee. Dr. Pasciak maintains a position as an associate professor of radiology at the University of Tennessee and is concurrently pursuing his MD degree at the Johns Hopkins University School of Medicine in Baltimore, Maryland. Dr. Pasciak is active in multiple research endeavors in the fields of interventional radiology and medical physics, and he has published papers in high impact journals. Dr. Pasciak has published 35 articles in peer-reviewed medical journals, presented 62 research abstracts at national meetings, has written 6 book chapters, and has filed 2 patents. He currently serves as principal investigator on three externally funded research grants involving radioembolization. Dr. Pasciak is certified by the American Board of Radiology (ABR) in diagnostic medical physics and is Mammography Quality Standards Act (MQSA) qualified.

J. Mark McKinney, MD, earned a medical degree at Loma Linda University School of Medicine in California where he completed a diagnostic radiology residency and interventional radiology fellowship. Dr. McKinney joined the Mayo Clinic in 1993. While at Mayo Clinic in Jacksonville, Florida, he developed the interventional radiology fellowship, mentored residents, made numerous presentations, and authored more than 60 peer-reviewed articles, abstracts, and book chapters. From 2008 to 2012 Dr. McKinney was Chair of Radiology at the University of Tennessee Medical Center and initiated the University of Tennessee interventional oncology radioembolization program.

Table of Contents

Series preface xi

Preface xiii

Editors xv

Contributors xvii

Part 1 Introduction 1

1 Introduction to hepatic radioembolization Andor F. Van Den Hoven Daniel Y. Sze Marnix G.E.H. Lam 3

Part 2 Patient Selection and Treatment Planning 31

2 Treatment options for patients with primary and secondary liver cancer: An overview of invasive, minimally invasive, and noninvasive techniques Ricardo Paz-Fumagalli David M. Sella Gregory T. Frey 33

3 Treatment planning part I: Vascular considerations associated with safety and efficacy in radioembolization Ray Bradford J. Mark McKinney 53

4 Treatment planning part II: Procedure simulation and prognostication Shyam M. Srinivas Sankaran Shrikanthan Naichang Yu Susan D. Kost Ram Gurajala Karunakaravel Karuppasamy 65

5 Treatment planning part III: Dosimetric considerations in radioembolization with glass and resin microspheres Alexander S. Pasciak Austin C. Bourgeois Yong C. Bradley 87

6 Radioembolization in segmentectomy, lobectomy, and future liver remnant hypertrophy Edward Kim Joseph Titano Safet Lekperic 113

Part 3 Treating Patients with Radioembolization 133

7 Radiation safety concerns associated with preparing the dosage, treating and releasing the patient, and managing radioactive waste William D. Erwin 135

8 The radiation biology of radioembolization Marta Cremonesi Francesca Botta Mahila Ferrari Lidia Strigari Guido Bonomo Franco Orsi Roberto Orecchia 167

9 Microsphere deposition, dosimetry, radiobiology at the cell-scale, and predicted hepatic toxicity Stephan Walrand 199

Part 4 Following Patients Treated with Radioembolization 219

10 Postradioembolization imaging using bremsstrahlung ⁹⁰Y SPECT/CT S. Cheenu Kappadath 221

11 Quantitative postradioembolization imaging using PET/CT Marco D'arienzo Luca Filippi Oreste Bagni 229

12 Image-based three-dimensional dosimetry following radioembolization Alexander S. Pasciak S. Cheenu Kappadath 251

13 Diagnostic reporting using postradioembolization imaging Yung Hsiang Kao 263

14 The use of postprocedural imaging in the medical management of patients Austin C. Bourgeois Marcelo S. Guimaraes Yong C. Bradley Christopher Hannegan Alexander S. Pasciak 281

Part 5 New Horizons 305

15 Future directions in radioembolization Alexander S. Pasciak J. Mark McKinney Yong C. Bradley 307

Index 323

Editorial Reviews

"This book will be a valuable resource for anyone already in the field of radioembolisation, whether it be for clinical or scientific guidance, as well as those just starting up and wishing to familiarise themselves with the procedure. It offers detailed insight into the many facets that contribute to successful therapy, and through its multidisciplinary nature promises be a useful tool in improving safety and efficacy of treatment, and establishing a personalised approach to radioembolisation."
—Dr. Kathy Willowson, The University of Sydney

"An essential book for anybody who is involved or is planning to start Y-90 radioemboliziation, covering state-of-the-art dosimetry approaches using bremsstrahlung SPECT/CT and PET/CT imaging, with excellent descriptions of advantages and limitations."
—Dr. Karin Knešaurek, Department of Radiology, Icahn School of Medicine, Mount Sinai Hospital

"a comprehensive yet practical study of selective internal radiation therapy. Representing the latest concepts and research relating to radioembolization, the book takes the reader through the basics in a logical and cohesive manner. The authors have managed to present complex topics and arms of controversy in an objective, scientific and honest manner, allowing the reader to adapt and evolve with the thought processes behind various advanced therapeutic strategies. This text should be part of a core curriculum for those users starting SIRT, and advanced users alike."
—David Liu, MD, Vancouver Imaging Inc and University of British Columbia

"a well written book on principles and practice of hepatic radioembolization, with excellent emphasis on dosimetry, radiobiology and post-therapy imaging. I strongly recommend this to all physicians engaged in treating liver tumors with radioembolization."
—Sanjeeva Kalva, MD, University of Texas Southwestern Medical Center

"provides a detailed account of the background, logistics, rationale, and key patient selection factors in the use of a multidisciplinary radiation implantation approach to hepatic cancers. The often misunderstood aspects of 90Y activity planning… are well covered and explained clearly"
—Andrew S. Kennedy, MD, Sarah Cannon Research Institute

"This book will be a valuable resource for anyone already in the field of radioembolisation, whether it be for clinical or scientific guidance, as well as those just starting up and wishing to familiarise themselves with the procedure. It offers detailed insight into the many facets that contribute to successful therapy, and through its multidisciplinary nature promises be a useful tool in improving safety and efficacy of treatment, and establishing a personalised approach to radioembolisation."
—Dr. Kathy Willowson, The University of Sydney

"An essential book for anybody who is involved or is planning to start Y-90 radioemboliziation, covering state-of-the-art dosimetry approaches using bremsstrahlung SPECT/CT and PET/CT imaging, with excellent descriptions of advantages and limitations."
—Dr. Karin Knešaurek, Department of Radiology, Icahn School of Medicine, Mount Sinai Hospital

"a comprehensive yet practical study of selective internal radiation therapy. Representing the latest concepts and research relating to radioembolization, the book takes the reader through the basics in a logical and cohesive manner. The authors have managed to present complex topics and arms of controversy in an objective, scientific and honest manner, allowing the reader to adapt and evolve with the thought processes behind various advanced therapeutic strategies. This text should be part of a core curriculum for those users starting SIRT, and advanced users alike."
—David Liu, MD, Vancouver Imaging Inc and University of British Columbia

"a well written book on principles and practice of hepatic radioembolization, with excellent emphasis on dosimetry, radiobiology and post-therapy imaging. I strongly recommend this to all physicians engaged in treating liver tumors with radioembolization."
—Sanjeeva Kalva, MD, University of Texas Southwestern Medical Center

"provides a detailed account of the background, logistics, rationale, and key patient selection factors in the use of a multidisciplinary radiation implantation approach to hepatic cancers. The often misunderstood aspects of 90Y activity planning… are well covered and explained clearly"
—Andrew S. Kennedy, MD, Sarah Cannon Research Institute

From the Publisher

Reviewer: Mark D. Hurwitz, MD (New York Medical College)
Description: This book addresses radioembolization as currently applied to treatment of malignant diseases involving the liver and provides a comprehensive overview of the physics and imaging pertinent to this treatment approach.
Purpose: Part of a series geared for medical physicists as a bridge between radiation oncology and medical imaging, this book is devoted to addressing this objective in regards to radioembolization. This is a worthy objective for a book targeted to a very specific group of individuals.
Audience: The book is written for medical physicists and a select subset of physicians interested in an in-depth appreciation of the physics and imaging related to radioembolization. Among clinicians, the book is likely to be of greatest interest to practicing nuclear medicine physicians and radiologists actively engaged in the treatment of this patient population. Fellows in these specialties may also find this book of interest.
Features: The book's five sections include an introductory chapter; patient selection and treatment planning; treating patients with radioembolization; following patients treated with radioembolization; and a chapter on new horizons. The book provides very detailed coverage of the physics and imaging issues pertinent to this treatment modality. There is virtually no coverage of direct patient care issues and presentation of clinical outcomes. While not a focus for medical physicists, discussion of these issues would have helped placed the current use of radioembolization into better context and made the book more appealing to a broader audience. Clinicians, including nuclear medicine specialists, radiologists, and radiation oncologists looking to better understand clinical care, will need to access other sources for this information.
Assessment: This book has a very detailed focus on the physics and imaging issues pertinent to radioembolization not easy to find elsewhere. As such, it will be of value to the subset of medical physicists and, to a more limited extent, clinicians actively engaged in radioembolization treatments seeking a deep understanding of these topics. Most involved in this field will want to reference additional sources to better appreciate the clinical aspects of this treatment modality.

Doody's Review Service