Handbook of Tuberculosis: Molecular Biology and Biochemistry / Edition 1

by Stefan H. E. Kaufmann, Eric Rubin

Overview

This first of the three-volume tuberculosis book series provides a comprehensive overview of molecular biological and biochemical aspects of tuberculosis. Edited by the undisputed world leader in the field, this is the most comprehensive book on the topic available, and the first in recent years to focus on both basic research and clinical aspects of TB.

Product Details

ISBN-13:	9783527318865
Publisher:	Wiley
Publication date:	03/03/2008
Pages:	453
Product dimensions:	7.00(w) x 9.70(h) x 1.10(d)

About the Author

Prof. Dr. Stefan H.E. Kaufmann is Founding Director of the Max Planck Institute for Infection Biology, Berlin. He has published more than 600 scientific articles and is member of numerous scientific societies and committees e.g. current President of the European Federation of Immunological Societies, and Chair of the Immunology division of the American Society of Microbiology. He has won numerous prestigious awards including the Scientific Prize of Smith Kline Beecham and the Pettenkofer Prize.

Eric Rubin is Professor of Immunology and Infectious Diseases at the Harvard School of Public Health. He carried out both his MD and PhD work at Tufts University.

Table of Contents

Tuberculosis -
Molecular Genetics and Biochemistry: Introduction
Biochemistry of the Cell Wall
Glycolipids and Polyketides of M. tuberculosis
Physiology of M. tuberculosis
Nutrient Transport
Iron Uptake by M. tuberculosis
Protein Transport
PE and PPE Gene Family Members in M. tuberculosis
Virulence/Persistence Mechanisms of M. tuberculosis
Genomics
Transcriptomics and Transcriptional Regulation
Proteomics of M. tuberculosis
Structure
Molecular Mechanisms of Dormancy and Resuscitation
M. tuberculosis in the Phagosome
Molecular Mechanisms of Drug Resistance of M. tuberculosis
Experimental Genetics of M. tuberculosis
Molecular Evolution of Mycobacteria

Editorial Reviews

Reviewer: Carlos E Figueroa Castro, MD (Medical College of Wisconsin)
Description: This is the first volume of a three-volume set covering all aspects of tuberculosis.
Purpose: As described in the foreword, the main purpose is to summarize, in a comprehensive manner, the existing knowledge on all aspects of tuberculosis. The book clearly meets the author's objectives. It is a welcome addition to the medical literature.
Audience: The book, and the set in general, is intended for a broad audience, targeted to every person who works with tuberculosis. The book will be a great introductory text to newcomers and healthcare providers looking for a basic understanding of the molecular biology and biochemistry of tuberculosis. Also, it will be an enjoyable literature update for more seasoned researchers. All the authors are world experts.
Features: This is a comprehensive review of diverse aspects of the molecular biology and biochemistry of Mycobacteria and tuberculosis, like the cell wall structure, iron uptake, protein transport, virulence factors, molecular mechanisms of latency, molecular evolution, and a summary on genomics, proteomics, and transcriptomics, to name a few. It has great discussion of PE and PPE proteins found in the analysis of the M.tuberculosis H37Rv strain, the molecular mechanisms involved in drug resistance, and an interesting discussion on smooth tubercle bacilli in the section on molecular evolution of mycobacteria. The chapters are well organized and are understandable to the neophyte. There is a brief history of tuberculosis at the beginning of the book. The illustrations are helpful and of good quality, most of them in color. The figures in chapter 4 must have been in color, but they are reproduced in black and white.
Assessment: These three volumes have the potential of becoming a must read for every person involved in tuberculosis research and clinical management. I predict this volume in particular will be an obligatory read for individuals interested in or entering basic science research in tuberculosis. I look forward to see updated versions in the future.

Doody's Review Service

I predict this volume in particular will be an obligatory read for individuals interested in or entering basic science research in tuberculosis. (Doody's, July 2008)

From the Publisher