Hemostasis and Thrombosis

by Thomas G. DeLoughery (Editor)

Overview

The latest edition of this practical handbook provides a concise yet comprehensive overview of common and rare problems with hemostasis and thrombosis. Through thoroughly updated and revised chapters, the text features practical information on diagnosing and managing troublesome hematologic conditions often found in clinical practice. The handbook also spotlights advances in the field since the publication of the last edition, including multiple novel coagulation factors for hemophilia, the increasing use of novel anticoagulants and their reversal agents, and the increasing use of genetics for diagnosis. 
Written by experts in the field, Hemostasis and Thrombosis, Fourth Edition is an invaluable resource for healthcare professionals who treat patients afflicted with these conditions.

Product Details

ISBN-13:	9783030193300
Publisher:	Springer-Verlag New York, LLC
Publication date:	08/10/2019
Sold by:	Barnes & Noble
Format:	eBook
File size:	2 MB

About the Author

Thomas G DeLoughery, MD, MACP, FAWM

Oregon Health&Sciences University

Department of Medicine, Pathology, and Pediatrics

Division of Hematology/Medical Oncology

Portland, OR 

USA

Table of Contents

Basics of Coagulation.- Tests of Hemostasis and Thrombosis.- Bleeding Disorders: A General Approach.- Hemophilia.- von Willebrand Disease.- Other Inherited Bleeding Disorders.- Acquired Bleeding Disorders.- Disseminated Intravascular Coagulation.- Liver and Renal Disease.- Cardiac Bypass and Ventricular Assist Devices/ECMO.- Immune Thrombocytopenia.- Thrombotic Microangiopathy (TTP/HUS).- Non-Blood Product Agents for Bleeding Disorders.- Transfusion Therapy and Massive Transfusions.- Deep Venous Thrombosis and Pulmonary Embolism.- Thrombosis in Unusual Sites.- Inherited Thrombophilias.- Aquired Thrombophilias.- Antiphospholipid Antibody Syndrome.- Antithrombotic Therapy for Cardiac Disease.- Stroke and Peripheral Vascular Disease.- Heparins and Heparin-Induced Thrombocytopenia.- Other Parenteral Anticoagulants.- Direct Oral Anticoagulants.- Warfarin.- Antiplatelet Agents.- Thrombolytic Therapy.- Clinical Dilemmas In Anticoagulation: Extremes Of Weight, Renal Disease, Recent Bleeding, And Surgery.- Bleeding and Thrombosis in Cancer Patients.- Hemostasis and Thrombosis in Pregnancy.- Hemorrhage and Thrombosis in Women.- Pediatric Thrombosis.

Editorial Reviews

2 Stars from Doody

This spiral-bound handbook discusses the clinical aspects of hemostasis and thrombosis. As the author states, "The handbook was written to offer a practical guide to recognizing, diagnosing, and managing these patients." It would be useful for a student or house officer who wants a brief guide for a patient with a coagulation problem. The aims are fairly well met, but the book could be improved in several areas. The book is most suitable for students and house officers. It could also be of use for any clinician seeking concise answers to questions about thrombosis and hemostasis. The author is knowledgeable in the field, but the book might have benefited from contributions by other experts in the field. The various subjects are fairly well reviewed, but there are some deficiencies. There are some proofreading errors, which at times are not critical, such as when the author calls the fibribolytic factor "tissue plasminogen activation" instead of the correct "tissue plasminogen activator." At other times, however, the errors are more significant. When discussing hemophilia B, the text misstates that there is a recombinant factor XI available, when the intention was to mention recombinant factor IX. One not familiar with the field could mistake this for a similar situation as the use of recombinant factor VIIa, which is intended for the treatment of hemophilia patients with inhibitors. The text is not fully referenced, but includes a selection of recommended further readings at the end of each chapter. The tables, overall, are well organized and helpful. The figures are mostly stylistic cartoons, which at times are confusing. One other shortcoming is the binding of this spiral-boundhandbook came apart with the first examination of the book, with only modest use. This is a fairly well done book. Although its quality is diminished due to the errors of language and proofreading, it still could serve as a useful handbook for students and house officers seeking help with problems of hemostasis and thrombosis.

Gerald A. Soff

A pocket-sized, wire-spire-bound handbook on both the common and uncommon hemostatic problems that health care providers face in clinical practice. Offers practical advice on recognizing, diagnosing, and managing patients with such problems. Pays much attention to the several thrombotic disorders and their therapy, including many drugs recently brought onto the market. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Vincent F Carr, DO, MSA, FACC, FACP (Uniformed Services University of the Health Sciences)
Description: This monograph explores the singular subject of how blood clots and the physiology of the clotting system may become unbalanced. The previous edition was published in 2004.
Purpose: This book brings together the current literature, producing a current, state-of-the-art understanding of coagulation physiology.
Audience: Intended for medically trained clinicians and researchers, this is a rather technical monograph requiring a basic knowledge of coagulation mechanisms.
Features: Chapters outline the basic physiology, then the historical diagnoses of bleeding problems. These are followed by outlines of how comorbid diagnoses can affect the coagulation scheme, such as liver and renal disease, and the need for cardiac bypass and ventricular assist devices. The final chapters cover the various available treatments, including the newer pharmaceuticals such as direct oral anticoagulants, antiplatelet medications, and thrombolytics.
Assessment: This timely and much-needed monograph updates the current thinking for all levels of clinicians from residency house staff through attending physicians. The book is well researched, well written, easy to read with understandable figures and tables.

Doody's Review Service

This book provides a foundational knowledge that is generalizable across many medical specialties, including anesthesiology. The book is also an easy read and should serve as a quick supplemental guide for those practitioners involved in management of patients with both common and uncommon bleeding and thrombotic disorders.” (Alan Smeltz and Harendra Arora, Anesthesia & Analgesia, Vol. 131 (5), November, 2020)

“The intended audience is students, residents, fellows, and clinicians with an interest in benign hematology, especially bleeding and thrombotic disorders. The book meets the needs of this audience because of its updated and comprehensive nature. … This is a high-quality, practical book for trainees and practicing physicians with an interest in hemostasis and thrombosis.” (George M Rodgers, Doody's Book Reviews, November 22, 2019)

From the Publisher