Homeostatic Control of Brain Function

by Detlev Boison, Susan A Masino

Overview

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders.

Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health.

Key Features include
· A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks.
· Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise.
· Incorporation of homeostatic therapies into existing basic and clinical research paradigms.
· Extensive scientific basic and clinical research ranging from molecules to disorders.
· Emerging practical information for improving homeostasis.
· Examples of homeostatic therapies in preventing and delaying dysfunction.

Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Product Details

ISBN-13:	9780199322299
Publisher:	Oxford University Press
Publication date:	12/01/2015
Pages:	658
Product dimensions:	7.10(w) x 9.50(h) x 1.50(d)

About the Author

Detlev Boison is the Robert Stone Dow Chair of Neurology; the Director of Neurobiology Research; and the Director of Basic and Translational Research at the Legacy Research Institute

Susan A. Masino is the Vernon Roosa Professor of Applied Science; and a Professor of Neuroscience and Psychology at Trinity College

Table of Contents

Prologue

Part I: Homeostatic Regulators: Molecules and Ions

Chapter 1: Microdynamics of water and ion homeostasis in the brain: role of aquaporins and ion channels of astroglial cells

Chapter 2: Homeostatic control of adenosine levels and functions in brain

Chapter 3: Glutamate homeostasis as a regulatory of neurotransmitter recycling and synaptic function)

Chapter 4: Homeostasis of neuronal excitability via synaptic and intrinsic inhibitory mechanisms

Part II: Homeostatic Control: Systems, Cells and Organelles

Chapter 5: Role of astrocytes in sleep and epilepsy

Chapter 6: Neuron-astrocyte interactions

Chapter 7: Homeostatic synaptic scaling at central synapses

Chapter 8: Homeostatic role of heterosynaptic plasticity

Chapter 9: The Blood Brain Barrier

Chapter 10: Inflammation and immunomodulation in epilepsy and its comorbidities

Chapter 11: Neuroplasticity

Chapter 12: Epigenetics

Chapter 13: Adult neural stem cells and brain homeostasis

Part III: Homeostatic Manipulators: Preventative and Restorative Opportunities

Chapter 14: Systems (network) pharmacology for brain functionality restoration

Chapter 15: Ketogenic diets, mitochondria, and neurological diseases

Chapter 16: Dietary manipulations

Chapter 17: Exercise

Chapter 18: Sleep

Chapter 19: Botanicals

Chapter 20: The role of acupuncture in nociception homeostasis

Chapter 21: Meditation

Chapter 22: Neurotrophic regulation in neurorestoration of brain

Part IV: Homeostatic Therapies for Disease and Dysfunction

Chapter 23: Epilepsy

Chapter 24: Traumatic Brain Injury

Chapter 25: Adenosine and Alzheimer's Disease, a possible epigenetic link

Chapter 26: Brain homeostasis and Parkinson's Disease

Chapter 27: Brain homeostasis and addiction

Chapter 28: Anxiety and stress disorders

Chapter 29: Malignant brain cancer management with metabolic therapy

Chapter 30: Obesity and diabetes: Nature, nurture, and beyond

Chapter 31: Autism spectrum disorders and homeostasis

Editorial Reviews

"Homeostatic Control of Brain Function is a serious resource for scientists at all levels. While outlining detailed mechanisms several dozen experts in the field consider how basic principles of homeostasis influence brain function from molecules to behavior. Accordingly, Homeostatic Control of Brain Function offers insights into why and how to restore homeostasis therapeutically, and perhaps non-pharmacologically. One of the most interesting aspects is up-to-date scientific information underling beneficial and available therapies such as meditation and acupuncture. In sum, Boison and Masino have organized a provocative and forward-looking book as we continue to grapple with new insights and develop therapies for complex and overlapping brain diseases." —Paul Lombroso, MD, Professor and Deputy Chair of Research, Child Study Center and Departments of Psychiatry and Neurobiology, Yale University School of Medicine

"This is an excellent textbook geared for basic scientists studying the metabolic regulation of the brain and methods in which to positively affect metabolism. It is extremely thorough yet very readable, with detailed references and figures. The authors are experts in their fields of study. A must-read for any neuroscientists working in the field of metabolism." —Eric H. W. Kossoff, M.D., Professor, Neurology and Pediatrics, Medical Director, Ketogenic Diet Center, Director, Pediatric Neurology Residency Program, Johns Hopkins Hospital, Baltimore, MD

From the Publisher