How the Human Genome Works / Edition 1

by Edwin H. McConkey

Overview

The perfect resource for nursing students, as well as practicing nurses and physicians, this unique text explains the basics of the human genome: what it is, what it does, and its implications in health and disease.

Product Details

ISBN-13:	9780763723842
Publisher:	Jones & Bartlett Learning
Publication date:	02/18/2004
Edition description:	1E
Pages:	118
Product dimensions:	11.00(w) x 8.25(h) x 0.27(d)

About the Author

Professor Emeritus, University of Colorado, Boulder, Colorado

Table of Contents

Lecture 1	Natural History of the Human Genome	1
	General Aspects of the Genome	1
	What's in a Gene?	4
	Repetitive DNA	6
	Chromatin	8
	Gene Expression	9
Lecture 2	The Mechanisms of Mutation: How the Human Genome Changes	19
	Spontaneous Mutations	19
	Induced Mutations	29
	The Human Mutation Rate	30
Lecture 3	Genetic Diseases: The Consequences of Mutation	35
	Mendelian Inheritance of Autosomal Genes	35
	Mendelian Inheritance of X and Y Chromosome Genes	39
	From Mendel to Genes	41
	On Beyond Mendel: Complex Inheritance	45
	Genomic Imprinting	49
Lecture 4	The Human Genome and Medical Practice	53
	Genetic Screening	53
	Therapy of Genetic Disorders	58
Lecture 5	The Mitochondrial Genome and Mitochondrial Disorders	69
	Mitochondrial Genetic Diseases	72
Lecture 6	The Genetic Basis of Cancer	79
	Oncogenes	80
	Tumor-Suppressor Genes	84
	Loss of Growth Control	86
Lecture 7	The Human Genome and Developmental Biology	95
	Prenatal Developmental Genetics	96
	Genetics of Aging	101
	A Look Ahead	102
	Glossary	107
	Index	113