Human Immunogenetics: Basic Principles and Clinical Relevance

by S. D. Litwin

Overview

Delineating fundamental concepts of contemporary immunogenetics, this reference/text examines specific immunogenetic systems in terms of molecular biochemistry and immunophysiology. Covers material in diverse fields, including infectious diseases, cell biology, virology, molecular genetics. Comprise

Product Details

ISBN-13:	9781000147162
Publisher:	CRC Press
Publication date:	10/28/2020
Series:	Immunology
Sold by:	Barnes & Noble
Format:	eBook
Pages:	856
File size:	11 MB
Note:	This product may take a few minutes to download.

About the Author

Stephen D. Litwin is Deputy Assistant Chief Medical Director for Research and Development at the Veterans Administration Central Office in Washington, D.C. He was formerly Scientific Director of the Guthrie Foundation for Medical Research in Sayre, Pennsylvania, and, prior to that, Professor of Medicine and Head of the Division of Human Genetics at Cornell University Medical College in New York City. The author or coauthor of some 90 articles, book chapters, and proceedings papers, he has coedited or coauthored five books, including Clinical Evaluation of Immune Function in Man and Developmental Immunobiology. Dr. Litwin serves as an editorial consultant for Marcel Dekker, Inc.’s Immunology Series. Among the professional organizations he belongs to are the American Society for Clinical Investigation, American Association of Immunologists, American Society of Human Genetics, and the Harvey Society. Dr. Litwin received the M.D. degree (1959) from New York University School of Medicine.

Table of Contents

Series Introduction (Noel R. Rose) -- Foreword (Merrill W. Chase) -- Preface (Stephen D. Litwin) -- Contributors -- Part I. Approaches and Tools of immunogenetics -- Introduction /Stephen D. Litwin -- 1. Acquiring Immunogenetic Data /Stephen D. Litwin -- 2. Human Gene Mapping and Linkage Analysis /Robert S. Sparkes -- 3. Laws of Transplantation /Henry J. Winn -- 4. Maternal-Fetal Immunogenetics /Rona J. Mogil and Thomas G. Wegmann -- 5. Molecular Biology: Tools and Applications /Brian A. Pollok -- 6. Monoclonal Antibodies as Applied to Tumor-Associated -- Antigens: The CO -1 A An ti gen /Alonzo H. Ross, Dorothee Herlyn, Zenon Steplewski, and Hilary Koprowski -- Part II. immunogenetics of Immunity -- Introduction /David W. Scott -- 7. Clonal Nature of the Immune Response /David W. Scott -- 8. Lymphoid Cell Development /Anthony R. Hayward -- 9. Antigen-Specific Immune Regulation /Judith A. Kapp and Carl W. Pierce -- 10. Immunoglobulin Genes /H. Perry Fell and Philip W. Tucker -- 11. Immunoglobulin Allotypes /Stephen D. Litwin -- 12. Autoimmune States /Michael Fischbach and Norman Talal -- 13. Immunodeficiency Diseases /Richard Hong -- Part Ill. immunogenetics of Histocompatibility and Related Systems -- Introduction /Lorraine Flaherty -- 14. Comparative Immunogenetics of the Major Histocompatibility Complex /Elizabeth P. Blankenhorn -- 15. Molecular Genetics of the Human Leukocyte Antigen Complex /Harry T. Orr -- 16. Minor Histocompatibility Loci /Peter J. Wettstein -- 17. Human Leukocyte Antigens and Disease /Frances E. Ward and D. Bernard Amos -- 18. Qa /Tla Antigens /James S. Michaelson -- 19. T-Lymphocyte Associative Recognition /Susan A. McCarthy and Alfred Singer -- 20. The T /t Complex and the Genetic Control of Mouse Development /Hee-Sup Shin -- Part IV. immunogenetics of Tumor and Viral Antigens -- Introduction /Stephen D. Litwin and Ralph A. Reisfeld -- 21. Epstein-Barr Virus and Its Antigens /Nancy Raab-Traub and Joseph S. Pagano -- 22. Human T-Lymphotropic Viruses /Flossie Wong-Staal -- 23. Immunogenetic Analysis of the Immune Response to Hepatitis B Virus Antigens /David R. Milich -- 24. Immunogenetics of Murine and Feline Retroviruses /John H. Wolfe and William D. Hardy, Jr. -- 25. Immunologic Response to Influenza Virus Infection /Mark Krystal -- 26. Retroviral-Related Genes, Proto-Oncogenes, and Breast Cancer /Robert Callahan, Maureeen 0. Weeks, Noriaki Ohuchi, and Jeffrey Schlom -- 27. Human Melanoma-Associated Antigens /Lloyd H. Graf, Jr. and Soldano Fe"one -- Part V. lmmunogenetics of Blood and Serum Components -- Introduction /Donald M. Marcus -- 28. The ABO, Hh, Secretor, and Lewis Systems /Donald M. Marcus -- 29. The Ii and P Blood Group Systems /Donald M. Marcus -- 30. MNSs and Gerbich Blood Group Systems /John J. Moulds and Wolfgang Dahr -- 31. The Rh Blood Group System /Patricia Tippett -- 32. Complement Genetics /Peter H. Schur -- Index.

Editorial Reviews

Delineating fundamental concepts of contemporary immunogenetics, this reference/text examines specific immunogenetic systems in terms of molecular biochemistry and immunophysiology. Covers material in diverse fields, including infectious diseases, cell biology, virology, molecular genetics. Comprises five parts: approaches and tools, immunity, clonal nature of the immune response, histocompatibility and related systems, tumor and viral antigens, blood and serum components. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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