Imaging Drug Action in the Brain / Edition 1

by Edythe D. London

Overview

Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail.

Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

Product Details

ISBN-13:	9780849388439
Publisher:	Taylor & Francis
Publication date:	12/21/1992
Pages:	432
Product dimensions:	6.12(w) x 9.19(h) x (d)

Table of Contents

Preface, Chapter 1. Neurobiological Substrates Mediating the Reinforcing Effects of Psychomotor Stimulant and Opiate Drugs, Chapter 2. Receptor Autoradiography as an Aid in Explaining Drug Action, Chapter 3. In Vitro Autoradiographic Studies of Drugs Acting at Dopamine Receptor Sites, Chapter 4. Studies of Benzodiazepine Receptors Using In Vivo Autoradiography, Chapter 5. CNS Receptors for Opioids, Chapter 6. Imaging Neuroreceptors to Study Drug Action in Living Human Brain, Chapter 7. Metabolic Mapping with Deoxyglucose Autoradiography as an Approach for Assessing Drug Action in the Central Nervous System, Chapter 8. Metabolic Mapping of the Effects of Psychomotor Stimulants, Chapter 9. Positron Emission Tomographic Studies on the Acute Effects of Psychoactive Drugs on Brain Metabolism and Mood, Chapter 10. Use of PET to Study Addiction in Humans, Chapter 11. Inter-Rater Reliability in Positron Emission Tomography Image Analysis, Chapter 12. Immunohistochemistry as a Strategy for Investigating the Functional Neuroanatomy of Drug Actions in the Brain, Chapter 13. In Situ Hybridization Histochemistry, Chapter 14. Identifying and Localizing Gene Expression Important for the Actions of Abused Drugs, Chapter 15. Advanced Electrophysiological Imaging Techniques for Studying Drug Effects, Index