Immunological Mechanisms and Therapies in Brain Injuries and Stroke

by Jun Chen, Xiaoming Hu, Mary Stenzel-Poore, John H. Zhang

Overview

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.​

Product Details

ISBN-13:	9781493944958
Publisher:	Springer New York
Publication date:	08/23/2016
Series:	Springer Series in Translational Stroke Research , #6
Edition description:	Softcover reprint of the original 1st ed. 2014
Pages:	386
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Old dogmas, surprising complexities, and novel therapeutic targets.- The critical roles of immune cells in acute brain injuries.- Vascular Inflammation in Ischemic Stroke: Adhesion Receptors Controlling Leukocyte-Endothelial Interactions.- Immune Cell-Derived Free Radicals in Acute Brain Injury.- The complement cascade in acute brain injury.- Matrix Metalloproteinases as an Inflammatory Mediator in the Neurovascular Unit.- Toll-Like Receptors in Ischemic Stroke and other Acute Brain Injuries.- Ion Transporters in Microglial Function: New therapeutic targets for neuroinflammation in ischemic stroke?.- Inflammation After Acute Brain Injuries Affects the Developing Brain Differently than the Adult Brain.- Systemic Immune Responses after Experimental Stroke.- Infectious Burden and Risk of Stroke.- Inflammatory Biomarkers in Patients with Acute Brain Injuries.- In vivo Imaging of Neuroinflammation in Acute Brain Injury.- Inflammation as a therapeutic target after subarachnoid hemorrhage:advances and challenges.- Minocycline, a Tetracycline Derivative, as a Potential Protective Agent for Acute Stroke.- Tolerization to Brain and Vascular Antigens: Targeting Autoimmunity after Acute Brain Injuries and Preventing Stroke.- The Role of PPARg in Stroke.- CD36: an inflammatory mediator in acute brain injury.- Cool Down the Inflammation:  Hypothermia as a Therapeutic Strategy for Acute Brain Injuries.- Index.

Editorial Reviews

This is an outstanding book on immune molecular and cellular treatment for brain injury and ischemia. … I recommend this book for all brain injury, stroke, and trauma investigators. This monograph is well written and profusely covered with pictures and postmortem slides reinforcing the concepts discussed. Students of Neurology and Neurosurgery will also find this a useful reference and stand alone book.” (Joseph J. Grenier, Amazon.com, October, 2015)

From the Publisher