Interleukin-10 / Edition 1

by Francesco M. Marincola

Overview

Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor transfectant models) or systemically (transgenic models, administration of soluble cytokine) provided. In addition, recent work has suggested that polymorphisms of the promoter region of IL-10 may segregate propulsions in high and low producers. Surprisingly, high IL-10 producers may be more predisposed to acquire cancer and other diseases. Finally, human observations demonstrate that systemic administration of IL-10 to normal volunteers is associated with very little toxicity and pro-inflammatory properties mediated through activation of effector cells of the innate immune response. Thus, the role that interleukin-10 plays in vivo in physiological or pathological conditions remains controversial. Thus, there exists a compelling need to summarize in a book the state of the science of this important cytokine. With the assistance of several experts in this field, Interleukin-10 has attempted this endeavor.

Product Details

ISBN-13:	9781587062858
Publisher:	Taylor & Francis
Publication date:	01/26/2006
Series:	Medical Intelligence Unit (Unnumbered)
Pages:	206
Product dimensions:	9.20(w) x 6.20(h) x 0.70(d)

About the Author

Francesco M. Marincola, Immunogenetic Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, U.S.A.

Table of Contents

Preface 1. Interleukin-10 1A. Structure and Function of IL-10 and the IL-10 Receptor IB. IL-10 Effects on Innate Immunity 1C. Interleukin-10 and Adaptive Immune Response 2. Experimental Models for the Analysis of IL-10 Function III. Genetic Polymorphism of IL-10 and Relevance to Immune Function 3A. Role of IL-10 in Autoimmune Pathology 3B. Interleukin-10 Gene Polymorphisms and Cancer 3C. IL-10 Gene Polymorphisms in Transplantation 3D. IL-10, Genetic Polymorphism and Its Relevance to Age-Related Diseases 4. IL-10: Role in Infectious Diseases V. Role of IL-10 in Allergy 5. Interleukin-10 in Allergic Disease VI. Role of IL-10 in Autoimmune Pathology 6. The Role of IL-10 in Autoimmune Pathology VII. Role of IL-10 in Transplantation 7. Role of Interleukin-10 in Transplantation VIII. Role of IL-10 in Inflammatory Disease 8A. Role of IL-10 in Reactive Arthritis and Ankylosing Spondylitis 8B. Interleukin-10 and Psoriasis 8C. IL-10: The Role in Crohn’s Disease 8D. IL-10 and Systemic Lupus Erythematosus 9. Role of IL-10 in Cancer