Table of Contents
Contributors ix
1 Macromolecutar Trafficking and Immune Evasion in African Trypanosomes Mark C. Field Jennifer H. Lumb Vincent O. Adung'a Nicola G. Jones Markus Engstler 1
1 General Overview of the Trypanosome Life Cycle 3
2 Immune Evasion Mechanisms 5
3 Endocytrc Pathways 16
4 Developmental Remodeling and Signaling 27
5 Sorting Signals 28
6 Secretory Protein Folding and Exocytosis 32
7 Golgi Apparatus; Functions and Replication 39
8 Ubiquitylation and Endocytosis of Trans-Membrane Domain Proteins 42
9 Evolution of the Trypanosome Endomembrane System 46
10 Conclusions and Future Perspectives 50
Acknowledgments 51
References 52
2 Biological and Biophysical Properties of Vascular Connexin Channels Scott Johnstone Brant Isakson Darren Locke 69
1 Introduction 71
2 The Vasculature 72
3 Connexin Channels 75
4 Gap Junctional Communication Pathways in the Vasculature 82
5 Permeability of Vascular Connexin Channels 87
6 Involvement of Connexins in Vascular Diseases 101
7 Concluding Remarks 104
Acknowledgments 105
References 105
3 Genotype-Phenotype Mapping: Developmental Biology Confronts the Toolkit Paradox Joel Atallah Ellen Larsen 119
1 Introduction 120
2 Understanding the Genotype-Phenotype Relationship 121
3 From Sequence to Form 125
4 Beyond Sequence 135
5 Case Study for Parsing Gene, Cell and Self-Organizing Roles in Morphogenesis 138
6 Conclusion 142
Acknowledgments 142
References 142
4 Role of Spindle Asymmetry in Cellular Dynamics Yves Barral Dimitris Liakopoulos 149
1 Introduction 150
2 Spindle Asymmetry and Control of Cell Cycle 152
3 Spindle Asymmetry During Asymmetric Cell Divisions 174
4 Concluding Remarks201
References 203
5 Cell Adhesion in Amphibian Gastrulation Rudolf Winklbauer 215
1 Introduction 216
2 Characteristics of Amphibian Gastrulation 217
3 Gastrula Tissue as a Liquid: Cell Adhesion, Cell Sorting, Boundary Formation, and Tissue Positioning 223
4 Collective Cell Migration, Cell Rearrangement, and Intercellular Migration 249
5 Conclusion 260
Acknowledgments 261
References 261
6 Molecular and Cell Biology of Testicular Germ Cell Tumors Paolo Chieffi Renato Franco Giuseppe Portella 277
1 Introduction 278
2 Epidemiology and Risk Factors 279
3 Histopathology 280
4 Prognostic and Diagnostic Markers 294
5 Therapy 297
6 Conclusions and Perspectives 301
Acknowledgments 301
References 302
7 Polarity Proteins and Cell-Cell Interactions in the Testis Elissa W.P. Wong C. Yan Cheng 309
1 Introduction 310
2 Rho GTPases and Cell-Cell Interactions in the Testis: Cdc42 315
3 Polarity Proteins and Cell-Cell Interactions in the Testis 327
4 The Apical ES-BTB-Basement Membrane Functional Axis in the Seminiferous Epithelium that Coordinates the Cellular Events of Spermiation and BTB Restructuring During the Seminiferous Epithelial Cycle of permatogenesis: The Role of Polarity Proteins in Mediating the Apical ES-BTB-Basement Membrane Axis 335
5 Roles of Polarity Proteins in Coordinating the Opposing Effects of Cytokines and Testosterone in Primary Preleptotene Spermatocyte Transit at the BTB 339
6 Concluding Remarks and Future Perspectives 341
Acknowledgment 342
References 342
Index 355
