Table of Contents
Contributors vii
1 Cross-Talk Among Integrin, Cadherin, and Growth Factor Receptor: Roles of Nectin and Nectin-Like Molecule Hisakazu Ogita Yoshimi Takai 1
1 Introduction 2
2 Molecular and Structural Features of Nectin and Nectin-Like Molecule 4
3 Formation of Adherens Junctions Induced by the Nectin-Afadin System 9
4 Formation of Tight Junctions Regulated by the Nectin-Afadin System 22
5 Roles of Nectin and Necl-5 27
6 Common Utilization of Signaling Molecules in Forming Leading Edges and Cell-Cell Adhesion 39
7 Concluding Remarks 40
References 41
2 Neural Stem Cells in the Mammalian Brain A. V. Revishchin L. I. Korochkin V. E. Okhotin G. V. Pavlova 55
1 Introduction 56
2 Neural Stem Cells and Their Niches in the Adult Mammalian Brain 57
3 Transcriptional Regulation of NSC Self-Renewal and Differentiation 68
4 Neural Stem and Progenitor Cell-Based Therapy 82
5 Conclusions 90
Acknowledgments 91
References 91
3 Mechanisms of Mitotic Spindle Assembly and Function Claire E. Walczak Rebecca Heald 111
1 Introduction 112
2 Molecular Components of the Mitotic Spindle 113
3 Major Pathways of Spindle Assembly 119
4 Mechanisms of Chromosome Congression and Attachment 129
5 Mechanisms of Chromosome Segregation 138
6 Conclusions and Future Directions 143
Acknowledgments 144
References 144
4 Multiple Actions of Secretin in the Human Body Ian P. Y. Lam Francis K. Y. Siu Jessica Y. S. Chu Billy K. C. Chow 159
1 Introduction 160
2 Structure and Regulation of Secretion and the Gene 163
3 Secretin's Actions in the Gastrointestinal Tract 164
4 Secretin's Actions in Other Tissues 172
5 Summary and Future Prospects 178
References 179
5Biology of the Striated Muscle Dystrophin-Glycoprotein Complex James M. Ervasti Kevin J. Sonnemann 191
1 Introduction 192
2 Composition of the Core Dystrophin-Glycoprotein Complex 192
3 Function in Mammals 195
4 Function in Model Organisms 205
5 Concluding Remarks 207
Acknowledgments 208
References 208
6 Providing Unique Insight into Cell Biology via Atomic Force Microscopy Victor Shahin Nelson P. Barrera 227
1 Introduction 228
2 AFM: Principle of Operation and Operation Modes 229
3 AFM Can Measure Forces and Elasticity 232
4 Advantages of AFM 234
5 Application of AFM to Biology 235
6 Conclusions 246
Acknowledgments 247
References 247
7 Characteristics of Oxysterol Binding Proteins Daoguang Yan Vesa M. Olkkonen 253
1 Introduction 254
2 Subcellular Distribution of the ORPs 258
3 Role of the Mammalian ORPs in Lipid Metabolism 262
4 The Yeast S. cerevisiae ORPs 269
5 Role of ORPs in Cell Signaling 272
6 Future Perspectives 274
Acknowledgments 276
References 277
Index 287
