Introduction to Neuropsychopharmacology

by Leslie Iversen

Overview

Introduction to Neuropsy chopharmacology expands on the molecular and cellular foundations of the classic Biochemical Basis of Neuropharmacology, Eighth Edition (Cooper, Bloom and Roth) by now including the behavioral methods used to study psychoactive drugs in experimental animals and in humans. Authored by four founders of modern neuroscience, this concise and comprehensive text covers the current series of medications used to treat diseases of the brain and nervous system - both psychiatric and neurologic - and the neuroscientific information that explains how these medications act on the brain from the molecular to the clinical level. The text ranges from psychotropic drugs that affect mood and behavior to anesthetics, sedatives, hypnotics, narcotics, anticonvulsants, and analgesics, as well as a variety of drugs that affect the autonomic nervous system and psychoactive drugs used for non-medical reasons - nicotine, alcohol, opiates, psychostimulants and cannabis.

Product Details

ISBN-13:	2900195380537
Publication date:	12/12/2008
Pages:	576
Product dimensions:	6.00(w) x 1.25(h) x 9.00(d)

Table of Contents

1 Introduction to Neuropsychopharmacology 3

2 Cellular and Molecular Foundations of Neuropsychopharmacology 6

3 Principles and Methods of Behavioral Pharmacology 29

4 Receptors 58

5 Amino Acid Neurotransmitters 85

6 Acetylcholine 128

7 Catecholamines 150

8 Serotonin 214

9 Histamine 238

10 Neuropeptides 254

11 Purinergic Pharmacology 269

12 Other Interneruronal Signals 277

13 Treatments for Neurological or Psychiatric Disorders: Principles of Central Nervous System Drug Development 293

14 Antidepressants and Anxiolytics 306

15 Antipsychotics 336

16 Cognitive Disorders 355

17 Movement Disorders 389

18 Pain 405

19 Epilepsy 416

20 Recreational Psychoactive Drugs 424

21 Psychostimulants 447

22 Heroin and Other Opiates 473

23 Psychedelics 482

24 Cannabis 490

25 Alcohol 503

26 Nicotine 519

Index 533

Editorial Reviews

Reviewer: Michael Schrift, DO (University of Washington School of Medicine)
Description: This is a marvelous new book (which is actually a version of the classic, The Biochemical Basis of Neuropharmacology, 8th edition, Cooper, Bloom and Roth (Oxford University Press, 2003)) covering "the principles by which the effects of drugs on behaviors, as well as on cells and circuits, are determined." Written and edited by giants in neuroscience, this book is a terrific addition to the medical literature.
Purpose: After the decision not to revise the eighth edition of Cooper, Bloom and Roth, the editors had a change of heart, but decided to relinquish "a lot of the academic minutiae" and produce this introductory textbook that focuses on "the study of drugs that affect the cells and circuits of the brain, and the brain's behavioral, emotional, and cognitive operations."
Audience: The targeted audience includes medical students as well as graduate students, house officers, and fellows.
Features: Topics covered include the cellular and molecular foundations, principles and methods, receptors, amino acid neurotransmitters, acetylcholine, catecholamines, serotonin, histamine, neuropeptides, purinergic pharmacology, and other interneuronal signals. In addition, the principles of CNS drug development for neurological and psychiatric disorders are covered. Clinically useful chapters cover such topics as antidepressants, antipsychotics, cognitive disorders, movement disorders, pain, epilepsy, recreational psychoactive drugs, psychostimulants, opiates, psychedelics, cannabis, alcohol, and nicotine.
Assessment: This informative and readable new introductory textbook of neuropsychopharmacology should be required reading for any medical student, graduate student, or physician interested understanding neuroscience. It is an outstanding learning tool.

Doody's Review Service

"...Marvelous...This informative and readable new introductory textbook of neuropsychopharmacology should be required reading for any medical student, graduate student, or physician interested [in] understanding neuroscience. It is an outstanding learning tool."—Doody's

"This is a valuable and comprehensive introductory text to the science of the nervous system, with insightful commentary on receptors, neurotransmitters, neuromodulators, and pharmacological manipulation of the central nervous system...The text is both user-friendly and intuitive and suitable for graduate students in the biological sciences, as well as any medical students or professionals who wish to understand neuroscience, or undergraduates with a particular interest in the field."—The Pharmacological Journal

"The Biochemical Basis of Neuropharmacology by Copper, Bloom and Roth, the predecessor of the current volume, served several generations of neuroscientists in English speaking countries by providing its readers with a well written and 'state of the art' text. We are now fortunate to have a new edition written by two of the original authors joined by two highly respected neuropharmacologists from Oxford who have been at the forefront of this specialty for several decades....this text is essential for anyone wishing to understand the basic mechanisms that underlie neuropharmacology... Many readers will appreciate the excellent illustrations that help to clarify some of the more complex mechanisms described in the text...I strongly recommend it to anyone wishing to get an insight into neuropharmacology."—Brian E. Leonard, Pharmacology Dept., National University of Ireland, as reviewed in Human Psychopharmacology: Clinical and Experimental

"...it has just the right amount of information to introduce and expand upon the subject for the novice and provide a refresher to those who have studied the subject previously. Its translational approach, which often includes a survey of the animal experiments that led to the discovery of therapeutic drugs, makes it an invaluable resource for teaching and to those unfamiliar with the basic methodologies used in psychiatric drug discovery." —The American Journal of Psychiatry

"A particular charm of the book continues to be its masterly and efficient communication of complex concepts in way that is understandable and even compelling to students, trainees, and nonexperts as well as worthy of the attention of experienced investigators...The book remains one of the most readable and reliable introductions to the basic, preclinical science of neuropsychopharmacology. The addition of new authors offers hope that this classic may continue into further editions." —Journal of Clinical Psychiatry

From the Publisher