Table of Contents
Preface ix
Further Reading xi
Biography xiii
Introduction to Part I Matjaz Zorko
From Building Blocks to 3-D Structure
Chapter 1 Amino Acids Matjaz Zorko 5
Chapter 2 Noncovalent Interactions Matjaz Zorko 21
Chapter 3 Structural Organization of Proteins Matjaz Zorko 35
Protein Biosynthesis and Posttranslational Modifications
Chapter 4 The Biosynthesis of Proteins Matjaz Zorko 61
Chapter 5 Posttranslational Modifications Matjaz Zorko 81
Folding of Proteins
Chapter 6 Protein Folding Matjaz Zorko 101
Chapter 7 Intracellular Sorting of Proteins Gunnar von Heijne 123
Protein Degradation
Chapter 8 Protein Turnover Matjaz Zorko 137
Introduction to Part II Astrid Gräslund
Chapter 9 Purification and Characterization of Proteins Matjaz Zorko 147
Chapter 10 Crystallography and X-Ray Diffraction Astrid Gräslund 159
Chapter 11 Optical Spectroscopy Astrid Gräslund 167
Chapter 12 Nuclear Magnetic Resonance (NMR) Astrid Gräslund 177
Chapter 13 Methods to Follow Protein Folding Astrid Gräslund 189
Chapter 14 Mass Spectrometry Astrid Gräslund 195
Chapter 15 Chemical Synthesis of Peptides and Proteins Ülo Langel 199
Introduction to Part III Tüt Land
Chapter 16 Protein Engineering and Gene Silencing Ülo Langel 215
Chapter 17 Protein-Ligand Interactions Ülo Langel 229
Chapter 18 Sequence Analysis and Function Prediction Tiit Land 245
Chapter 19 Protein Structure Prediction Tiit Land 257
Chapter 20 Proteomics Sherry Niessen Benjamin F. Cravatt 263
Introduction to Part IV Ülo Langel
Chapter 21 Enzymes Matjaz Zorko 283
Chapter 22 Nucleic Acid-Binding Proteins Ülo Langel 313
Chapter 23 Cell Surface Receptors and Signaling Ülo Langel 323
Chapter 24 Membrane Proteins Gunnar von Heijne 337
Chapter 25 Antibodies Ülo Langel 343
Chapter 26 Fibrous Proteins Ülo Langel 355
Chapter 27 Selected Classes of Bioactive Peptides Ülo Langel 365
Introduction to Part V Ülo Langel Astrid Gräslund
Chapter 28 Misfolding-Based Diseases Astrid Gräslund 381
Chapter 29 Miscleavage-Based Diseases Astrid Gräslund 389
Chapter 30 Missequence-Based Diseases Astrid Gräslund 395
Chapter 31 Peptides and Proteins as Drugs Ülo Langel 401
Index 415
