Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology / Edition 1

by William M. Pardridge MD

Overview

Knowledge of the blood-brain barrier forms an essential component in the understanding of a large proportion of medical disciplines. Nevertheless, ignorance in this field still impedes progress in many areas, including cerebrovascular disease, Alzheimer's disease, cerebral AIDS, brain tumors, and the development of effective new neuropharmaceuticals. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Recent advances in both methodology and biology are detailed in fifty state-of-the-art chapters written by international authorities.

Product Details

ISBN-13:	9780521581240
Publisher:	Cambridge University Press
Publication date:	08/28/1998
Edition description:	New Edition
Pages:	502
Product dimensions:	7.52(w) x 10.00(h) x 1.14(d)

About the Author

Pardridge, William M., MD (UCLA Medical School)

Table of Contents

List of contributors; 1. Blood-brain barrier methodology and biology; Part I. Methodology: 2. The carotid artery single injection technique; 3. Development of the Brain Efflux Index (BEI) method and its application to the blood-brain barrier efflux transport study; 4. In situ brain perfusion; 5. Intravenous injection/pharmacokinetics; 6. Isolated brain capillaries: an in vitro model of blood-brain barrier research; 7. Isolation and behavior of plasma membrane vesicles made from cerebral capillary endothelial cells; 8. Patch clamp technique with isolated brain microvessel membranes; 9. Tissue culture of brain endothelial cells - induction of blood-brain barrier properties by brain factors; 10. Brain microvessel endothelial cell culture systems; 11. Intracerebral microdialysis; 12. Blood-brain barrier permeability measured with histochemistry; 13. Measuring local cerebral capillary permeability-surface area products by quantitative autoradiography; 14. Measurement of blood-brain barrier permeability in humans using indicator diffusion; 15. Measurement of blood-brain barrier permeability in humans with positron emission tomography; 16. Magnetic resonance imaging of blood-brain barrier permeability; 17. Molecular biology of brain capillaries; Part II. Transport Biology: 18. Biology of the blood-brain glucose transporter; 19. Glucose transporters in mammalian brain development; 20. Blood-brain barrier amino acid transport; 21. P-glycoprotein, a guardian of the brain; 22. Blood-brain barrier ion transport; 23. Ion channels in endothelial cells; 24. Interactions of lipoproteins with the blood-brain barrier; 25. Fatty acid and lipid intermediate transport; 26. Blood-brain barrier transport of drugs; Part III. General Aspects of CNS Transport: 27. The blood-CSF barrier and the choroid plexus; 28. Arachnoid membrane, subarachnoid CSF and pia-glia; 29. Circumventricular organs of the brain; 30. Transport in the developing brain; Part IV. Signal Transduction/Biochemical Aspects: 31. Regulation of brain endothelial cell tight junction permeability; 32. Chemotherapy and chemosensitization; 33. Lipid composition of brain microvessels; 34. Brain microvessel antigens; 35. Molecular dissection of tight junctions: occludin and ZO-1; 36. Phosphatidylinositol pathways; 37. Nitric oxide and endothelin at the blood-brain barrier; 38. Role of intracellular calcium in regulation of brain endothelial permeability; 39. Cytokines and the blood-brain barrier; 40. Blood-brain barrier and monoamines, revisited; Part V. Pathophysiology in Disease States: 41. Cerebral amyloid angiopathy; 42. Brain microvasculature in multiple sclerosis; 43. Hemostasis and the blood-brain barrier; 44. Microvascular pathology in cerebrovascular ischemia; 45. HIV infection and the blood-brain barrier; 46. Hypertension; 47. The blood-brain barrier in brain tumours; 48. The pathophysiology of blood-brain barrier dysfunction due to traumatic brain injury; 49. Cerebral malaria and the brain microvasculature; 50. Molecular basis of tissue tropism of bacterial meningitis.

Editorial Reviews

"This book, introducing the essential methodologies, biology and pathology of the blood-brain barrier, is welcome, especially when edited by a known expert in the field, William M. Pardridge...recommended reading to those wishing to enter this challenging area of drug delivery" Journal of Controlled Release

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