Kelley's Textbook of Rheumatology: Expert Consult Premium Edition - Enhanced Online Features and Print, 2-Volume Set / Edition 9

by Gary S. Firestein MD, Ralph C. Budd MD, Sherine E Gabriel MD, MSc, Iain B McInnes PhD, FRCP, FRSE, FMedSci, James R. O'Dell MD

Overview

Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rheumatology book’s sweeping updates highlight current advances and breakthroughs that impact your practice. With Kelley's Textbook of Rheumatology, you'll be ready to handle the toughest clinical challenges you face.

• Search the entire contents online at www.expertconsult.com, download all of images, and watch videos demonstrating the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints.

• Review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance with the integrated chapter format that readers of Kelley's Textbook of Rheumatology have always appreciated.
• Gain a thorough understanding of the "whys" and "hows" of rheumatic disease management with detailed coverage of the very latest breakthroughs and the newest clinical algorithms.

• Apply the latest therapeutic advances through new chapters in bioengineering and tissue engineering, as well as up-to-date coverage of gout and disease-modifying drugs.
• Learn how the study of biomarkers across populations can help you detect diseases earlier and with greater accuracy with a new chapter on epigenetics.
• Diagnose, monitor, and manage rheumatic disease more effectively with expanded information on the use of ultrasound and other imaging modalities.

Product Details

ISBN-13:	9781437717389
Publisher:	Elsevier Health Sciences
Publication date:	09/21/2012
Edition description:	Older Edition
Pages:	2292
Sales rank:	726,346
Product dimensions:	9.70(w) x 11.80(h) x 4.40(d)

About the Author

Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis.
Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004).

Iain McInnes is Director of the Institute of Infection, Immunity and Inflammation at the University of Glasgow, UK. He has extensive experience in leading multicenter programs nationally and internationally. He is Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Program, Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery program (PROMISERA), and chief investigator of numerous global phase II and III clinical trials of novel immune therapies. He has served as member or chair of numerous national grant-funding panels and as chair of several European League Against Rheumatism (EULAR) scientific committees – he is now Treasurer and President Elect of EULAR serving on its Steering Committee. He is formerly Chairman of the Foundation for European Rheumatology Research (Foreum) Scientific Committee and leads the EULAR-supported European Roadmap Program that is defining the research agenda for rheumatology for the next decade.

James R. O’Dell, MD is the Stokes Shackleford Professor of Internal Medicine, Vice-Chairman of Internal Medicine and Chief of the Division of Rheumatology at the University of Nebraska Medical Center (UNMC) in Omaha. Dr. O’Dell founded and has directed the Rheumatoid Arthritis Investigational Network (RAIN) for the last 25 years. Dr. O’Dell is the PI of the large multinational RA research study based at the VA through their cooperative studies program. Dr. O’Dell has published extensively, mostly in the area of rheumatoid arthritis. He has presented frequently at national and international meetings and has more than 100 published articles in top-level rheumatology journals. He has served on numerous American College of Rheumatology (ACR) committees over the last 20 years, including time on both the ACR and REF BOD, as well as a two-year term as President of the Research and Education Foundation of the ACR and was President of the College (2011-2012). Additionally, he is Editor-in-Chief of Up To Date for Rheumatology.

Table of Contents

VOLUME I

STRUCTURE AND FUNCTION OF

BONE, JOINTS, AND CONNECTIVE

TISSUE, 1

1 Biology of the Normal Joint, 1

2 Synovium, 20

3 Cartilage and Chondrocytes, 33

4 Biology, Physiology, and Morphology

of Bone, 61

5 Muscle: Anatomy, Physiology,

and Biochemistry, 67

6 Biomechanics, 79

7 Regenerative Medicine and Tissue

Engineering, 90

8 Proteinases and Matrix

Degradation, 97

CELLS INVOLVED IN

AUTOIMMUNE DISEASES

AND INFLAMMATION, 117

9 Dendritic Cells, 117

10 Mononuclear Phagocytes in Rheumatic

Diseases, 134

11 Neutrophils, 152

12 Eosinophils, 170

13 T Lymphocytes, 174

14 B Cells, 191

15 Fibroblasts and Fibroblast-like

Synoviocytes, 215

16 Mast Cells, 232

17 Platelets, 245

EFFECTOR MECHANISMS IN

AUTOIMMUNITY AND

INFLAMMATION, 255

18 Innate Immunity, 255

19 Adaptive Immunity and Organization of Lymphoid

Tissues, 268

20 Autoimmunity, 281

21 Genetics of Rheumatic Diseases, 299

22 Epigenetics, 316

23 Complement System, 325

24 Prostaglandins, Leukotrienes, and Related

Compounds, 340

25 Cell Recruitment and Angiogenesis, 358

26 Cytokines, 369

27 Cell Survival and Death in Rheumatic

Diseases , 382

28 Experimental Models for Rheumatoid

Arthritis, 400

29 Neural Regulation of Pain and Infl ammation, 413

BROAD ISSUES IN THE APPROACH TO

RHEUMATIC DISEASE, 431

30 Principles of Epidemiology in Rheumatic

Disease, 431

31 Economic Burden of Rheumatic

Diseases, 440

32 Clinical Trial Design and Analysis, 452

33 Assessment of Health Outcomes, 462

34 Biologic Markers, 476

35 Occupational and Recreational Musculoskeletal

Disorders, 493

36 Cardiovascular Risk in Rheumatic

Disease, 505

37 Cancer Risk in Rheumatic Diseases, 515

38 Introduction to Physical Medicine, Physical

Therapy, and Rehabilitation, 528

39 Pregnancy in the Rheumatic Diseases, 540

EVALUATION OF GENERALIZED AND

LOCALIZED SYMPTOMS, 559

40 History and Physical Examination of the

Musculoskeletal System, 559

41 Acute Monoarthritis, 577

42 Polyarticular Arthritis, 587

43 The Skin and Rheumatic Diseases, 599

44 The Eye and Rheumatic Diseases, 617

DIFFERENTIAL DIAGNOSIS OF REGIONAL

AND DIFFUSE MUSCULOSKELETAL

PAIN, 625

45 Neck Pain, 625

46 Shoulder Pain, 639

47 Low Back Pain, 665

48 Hip and Knee Pain, 683

49 Foot and Ankle Pain, 700

50 Hand and Wrist Pain, 708

51 Temporomandibular Joint Pain, 721

52 Fibromyalgia, 733

DIAGNOSTIC TESTS AND PROCEDURES IN

RHEUMATIC DISEASES, 753

53 Synovial Fluid Analyses, Synovial Biopsy,

and Synovial Pathology , 753

54 Arthrocentesis and Injection of Joints and Soft

Tissue, 770

55 Antinuclear Antibodies, 789

56 Autoantibodies in Rheumatoid Arthritis, 804

57 Acute Phase Reactants and the Concept

of Infl ammation, 818

58 Imaging Modalities in Rheumatic Diseases , 830

PHARMACOLOGY OF ANTIRHEUMATIC

DRUGS, 871

59 Prostanoid Biology and Its Therapeutic

Targeting, 871

60 Glucocorticoid Therapy, 894

61 Traditional DMARDs: Methotrexate, Lefl unomide,

Sulfasalazine, Hydroxychloroquine, and

Combination Therapies, 917

62 Immunosuppressive Drugs, 941

63 Anticytokine Therapies, 957

64 Cell-Targeted Biologics and Targets:

Rituximab, Abatacept, and Other

Biologics, 978

65 Antihyperuricemic Agents, 1001

66 Analgesic Agents in Rheumatic

Disease, 1014

67 Psychosocial Management of Rheumatic

Diseases, 1034

68 Nutrition and Rheumatic Diseases, 1044

VOLUME II

RHEUMATOID ARTHRITIS, 1059

69 Etiology and Pathogenesis of Rheumatoid

Arthritis , 1059

70 Clinical Features of Rheumatoid

Arthritis , 1109

71 Treatment of Rheumatoid Arthritis, 1137

72 Early Synovitis and Early Undifferentiated

Arthritis, 1161

73 Sjögren’s Syndrome, 1169

SPONDYLOARTHROPATHIES, 1193

74 Pathogenesis of Ankylosing Spondylitis and

Reactive Arthritis, 1193

75 Ankylosing Spondylitis, 1202

76 Reactive Arthritis and Undifferentiated

Spondyloarthritis, 1221

77 Psoriatic Arthritis, 1232

78 Enteropathic Arthritis, 1251

SYSTEMIC LUPUS ERYTHEMATOSUS AND

RELATED SYNDROMES, 1269

79 Etiology and Pathogenesis of Systemic Lupus

Erythematosus, 1269

80 Clinical Features of Systemic Lupus

Erythematosus, 1283

81 Treatment of Systemic Lupus

Erythematosus, 1304

82 Antiphospholipid Syndrome, 1331

SCLERODERMA, INFLAMMATORY

MYOPATHIES, AND OVERLAP

SYNDROMES, 1343

83 Etiology and Pathogenesis of Scleroderma, 1343

84 Clinical Features and Treatment of

Scleroderma, 1366

85 Infl ammatory Diseases of Muscle and Other

Myopathies, 1404

86 Overlap Syndromes, 1431

VASCULITIS, 1453

87 Classifi cation and Epidemiology of Systemic

Vasculitis, 1453

88 Giant Cell Arteritis, Polymyalgia Rheumatica, and

Takayasu’s Arteritis, 1461

89 Antineutrophil Cytoplasm Antibody–Associated

Vasculitis, 1481

90 Polyarteritis Nodosa and Related Disorders, 1498

91 Immune Complex–Mediated Small Vessel

Vasculitis, 1508

92 Primary Angiitis of the Central Nervous

System, 1518

93 Behçet’s Disease, 1525

CRYSTAL-INDUCED AND

INFLAMMASOME-MEDIATED

INFLAMMATION, 1533

94 Etiology and Pathogenesis of Hyperuricemia

and Gout , 1533

95 Clinical Features and Treatment of Gout, 1554

96 Calcium Crystal Disease: Calcium

Pyrophosphate Dihydrate and Basic

Calcium Phosphate , 1576

97 Familial Autoinfl ammatory Syndromes, 1597

CARTILAGE, BONE, AND HERITABLE

CONNECTIVE TISSUE DISORDERS, 1617

98 Pathogenesis of Osteoarthritis, 1617

99 Clinical Features of Osteoarthritis, 1636

100 Treatment of Osteoarthritis , 1646

101 Metabolic Bone Disease, 1660

102 Proliferative Bone Diseases, 1680

103 Osteonecrosis, 1692

104 Relapsing Polychondritis , 1712

105 Heritable Diseases of Connective Tissue, 1719

RHEUMATIC DISEASES OF

CHILDHOOD, 1741

106 Etiology and Pathogenesis of Juvenile

Idiopathic Arthritis, 1741

107 Treatment of Juvenile Idiopathic Arthritis, 1752

108 Pediatric Systemic Lupus Erythematosus,

Dermatomyositis, Scleroderma, and

Vasculitis, 1771

INFECTION AND ARTHRITIS, 1801

109 Bacterial Arthritis, 1801

110 Lyme Disease, 1815

111 Mycobacterial Infections of Bones

and Joints, 1829

112 Fungal Infections of Bones and

Joints, 1841

113 Rheumatic Manifestations of Human

Immunodefi ciency Virus Infection, 1851

114 Viral Arthritis, 1865

115 Poststreptococcal Arthritis and Rheumatic

Fever, 1875

ARTHRITIS ACCOMPANYING

SYSTEMIC DISEASE, 1889

116 Amyloidosis, 1889

117 Sarcoidosis , 1898

118 Hemochromatosis, 1907

119 Hemophilic Arthropathy, 1915

120 Rheumatologic Manifestations of

Hemoglobinopathies, 1924

121 Endocrine Diseases and the Musculoskeletal

System, 1927

122 Musculoskeletal Syndromes in Malignancy, 1934

123 Tumors and Tumor-like Lesions of Joints and

Related Structures, 1951

What People are Saying About This

From the Publisher

Master the latest advances in rheumatic disease management

Editorial Reviews

Reviewer: Deepali P Sen, M.D.(Washington University Medical Center)
Description: This has been the definitive textbook in rheumatology for decades, and the list of contributing authors is suitably impressive. It is a treat to read a book where every chapter is written by people at the very top of their field. The previous edition was published in 2009.
Purpose: According to the preface, the aim of this edition is to comprehensively cover rheumatology while reflecting recent changes, especially the advances in molecular medicine and emerging targeted therapies. It also focuses on graphics to improve presentation. This is a classic, and this is a much anticipated update. The chapters are well selected, covering not only aspects of disease and treatment but also focusing on cellular biology and mechanisms of autoimmunity.
Audience: Practitioners and trainees in rheumatology are the intended audience.
Features: Volume one is especially appreciated for its in-depth coverage of the structure and function of the various aspects of the immune system, the chapter on autoimmunity, and experimental models of arthritis. Also useful is the section on pharmacology that covers everything from steroids to biologics. Volume two covers aspects of diagnosis, pathogenesis, clinical features, and treatment of various rheumatic diseases.
Assessment: The ninth edition has many positive changes, including in the presentation, such as color coding of sections and charts and diagrams, which have made the information easier to assimilate. The book also provides up-to-date information while keeping with the traditional feel of previous editions. In times where electronic media have taken over print media, Kelley's still draws readers. It is likely the most definitive rheumatology book not only in the U.S., but also in the rest of the world.

Doody's Review Service

"The ninth edition has many positive changes, including in the presentation, such as color coding of sections and charts and diagrams, which have made the information easier to assimilate. The book also provides up-to-date information while keeping with the traditional feel of previous editions. In times where electronic media have taken over print media, Kelley's still draws readers. It is likely the most definitive rheumatology book not only in the U.S., but also in the rest of the world".- Deepali P Sen, M.D.(Washington University Medical Center) Doody 5 star review!

From the Publisher