Leptin and Reproduction / Edition 1

by Michael C. Henson, V. Daniel Castracane

Overview

The polypeptide leptin has been extensively studied as a factor involved in the regulation of appetite and the physiology of obesity. This text for scientists and clinicians working in reproductive biology focuses on leptin's lesser-known role as a reproductive hormone. Twenty contributions from research scientists are arranged into sections on general reproductive function, puberty, pregnancy, genetics, and clinical challenges. Topics include, for example, the effects of leptin on ovarian steroidogenesis, male reproductive potential, and hypothalamic amenorrhea. Annotation ©2003 Book News, Inc., Portland, OR

Product Details

ISBN-13:	9780306474880
Publisher:	Springer US
Publication date:	05/31/2003
Edition description:	2003
Pages:	352
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

Introduction. 1. Leptin: From Satiety Signal to Reproductive Regulator; M.C. Henson, et al. General Reproductive Function. 2. Neuroendocrine Regulation of Leptin Secretion and its Role in Nitric Oxide Secretion; S.M. McCann, et al. 3. Endocrine Regulation of Leptin Production; R.V. Considine. 4. Regulation and Roles of Leptin During the Menstrual Cycle and in Menopause; I. Messinis, E. Domali. 5. Impact of Leptin on Ovarial Folliculogenesis and Assisted Reproduction; J.D. Brannian, K.A. Hansen. 6. The Effect of Leptin on Ovarian Steroidogenesis; L.J. Spicer. 7. Regulation of Leptin and Leptin Receptor in the Human Uterus: Possible Roles in Implantation and Uterine Pathology; V.D. Castracane, M.C. Henson. 8. Leptin and Reproduction in the Male; J. Lado-Abeal, R.L. Norman. Puberty. 9. Leptin and Pubertal Development in Higher Primates; D.R. Mann, T.M. Plant. 10. Leptin and Pubertal Development; S. Blüher, C.S. Mantzoros. 11. Interaction of Leptin with Other Signals Regulating the Timing of Puberty: Lessons Learned from the Sheep Model; D.L. Foster, L.M. Jackson. Pregnancy. 12. Leptin and Fetal Growth and Development; H. Christou, C.S. Mantzoros. 13. Leptin in the Placenta; B.J. Waddell, J.T. Smith. 14. Leptin in Rodent Pregnancy; B.J. Waddell, J.T. Smith. 15. Leptin in Primate Pregnancy; M.C. Henson, V.D. Castracane. Genetics. 16. Genetics and Physiology Link Leptin to the Reproductive System; F.F. Chehab, et al. 17. Leptin and the Onset of Puberty: Insights from Rodent and Human Genetics;I. Sadaf Farooqi. Clinical Challenges. 18. Does Leptin Play a Role in Pre-Eclampsia? L. Poston. 19. Leptin and the Regulation of Hypothalmic Amenorrhea; M.P. Warren, J.E. Dominguez. 20. The Role of Leptin in Polycystic Ovary Syndrome; D.A. Magoffin, et al.

Editorial Reviews

"...this treatise serves as an essential reference which compiles in a single volume, the multiple effects of leptin."
(Virendra B. Mahesh, Ph.D., D.Phil., Medical College of Georgia, Augusta)

"This is a wonderful, timely and comprehensive volume. It provides source material and references for the new investigator to this area, provides challenges and provokes new thoughts and ideas to the established investigator, and it clearly takes forward the role of leptin as being much more than just an appetite hormone, but a critical regulator of physiologic functions. I congratulate all the authors, and the editors on this superb volume."
(John R.G. Challis, D.Sc., F.R.S.C., University of Toronto, Canada)
"This book is an extremely useful resource for summarizing an important and rapidly growing field. It covers a broad range of topics related to leptin and reproduction, including major sections devoted to general reproductive function, puberty, pregnancy and genetics. The final section, Clinical Challenges, includes discussion of the potential roles of leptin in pre-eclampsia, hypothalamic amenorrhea, and polycystic ovarian syndrome.[...] The editors are leaders in this field and have made an obvious effort to present each chapter in a consistent style and layout, with appropriate and sufficient use of real data and, in some cases, images. [...]Leptin and Reproduction is encompassing and analytical, and a valuable resource for anyone studying the importance of leptin in reproduction."
(Laura C. Schulz and Eric P. Widmaier, Dept. of Biology, Boston University, MA)

From the Publisher