Macrophages and Related Cells / Edition 1

by Michael A. Horton

Overview

To produce a comprehensive overview of macrophages and related cell types in a short review volume is an impossible task. When I selected the topics to be included, some equally important areas were omitted by necessity, and for this I apologize. My choices have been somewhat eclectic, touching subjects of personal interest (such as osteoclast biology and macrophage electrophysiology) or of current fashion (apopto­ sis, antigen processing, cell adhesion molecules). The book has also had to encompass areas of a more general flavor to provide balance for the general reader (such as reviews of macrophage development, heterogeneity, and function, and of the surface molecules expressed by macrophages). I thank all the authors for their prompt sub­ missions; all have been of high quality, and my editorial tasks, thankfully, have been minimal. Michael A. Horton London, United Kingdom ix Contents Chapter J An Overview of Receptors of MPS Cells lain Fraser and Siam on Gordon 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Mononuclear Phagocyte System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3. Diversity of Macrophage Plasma Membrane Receptors. . . . . . . . . . . . . . . . 6 3. 1 A Structural Approach to Classification . . . . . . . . . . . . . . . . . . . . . . . . . . 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 2 Multisubunit Receptors 3. 3 Soluble Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 4 Lectins and Lectin-Like Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Functions and Selected Examples. . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . 14 4. 1 Growth, Differentiation, and Modulation . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 2 Cell-Cell and Cell-Matrix Interactions. . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 3 Endocytosis and Scavenger Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 4 Secretory Responses and Biosynthesis of Effector Molecules . . . . . . 17 5. Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 6. References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 . . . . . . . . . . . . . . . . . . . .

Product Details

ISBN-13:	9780306443626
Publisher:	Springer US
Publication date:	05/31/1993
Series:	Blood Cell Biochemistry , #5
Edition description:	1993
Pages:	434
Product dimensions:	7.01(w) x 10.00(h) x 0.28(d)

About the Author

Horton, Michael A. (St Bartholomew's Hospital, London)

The contributors represent the specialties of physiology, nephrology, infectious disease, immunology, respiratory medicine, pathology, cell biology, rheumatology, biochemistry, anatomy, and blood transfusion. Most come from academic medical centers in the U.K. and the U.S. Several are from other countries, including Canada, Holland, and Australia. Institutions prominently represented include Univ of Western Ontario, Washington Univ, and Howard.

Table of Contents

1 An Overview of Receptors of MPS Cells.- 2 Heterogeneity of Mononuclear Phagocytes: An Interpretive Review.- 3 Origin of Macrophages.- 4 Complement and the Mononuclear Phagocyte System.- 5 Macrophages and Prostaglandins.- 6 Antigen Processing.- 7 Antigens of Osteoclasts: Phenotypic Definition of a Specialized Hemopoietic Cell Lineage.- 8 Electrophysiology of Osteoclasts and Macrophages.- 9 Complement Receptors.- 10 Fc? Receptors of Myeloid Cells.- 11 Matrix Receptors of Myeloid Cells.- 12 Leukocyte Integrins.- 13 Molecular Basis for Leukocyte Adhesion Molecule Deficiency.- 14 Carbohydrate-Recognition Proteins of Macrophages and Related Cells.- 15 Leukocyte Adhesion to Endothelium.- 16 Cell Recognition of Apoptotic Cells.

Editorial Reviews

The fifth volume in this series comprises sixteen papers which represent a balanced, although necessarily incomplete, review of macrophages and related cell types. For generalists, it includes articles on macrophage development, heterogeneity and function, and on the surface molecules expressed by macrophages. More specialized topics include apoptosis, antigen processing, cell adhesion molecules, osteoclast biology, and macrophage electrophysiology. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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