Mammalian Amino Acid Transport: Mechanism and Control / Edition 1

by D. Hïussinger, M.S. Kilberg

Overview

Amino acid transport is a part of each of two larger subjects, amino acid metabolism and the biomembrane transport of various . small molecules and ions. Nevertheless in this volume we treat amino acid transport as more than a fragment of either of these two larger subjects. A more comprehensive approach is justified when we remember two historic and ongoing aspects of the title subject. First, amino acid transport had its beginning and acquired a distinct momentum (even if somewhat interrupted from 1913 until about 1945) as amino acid metabolism with the central and pioneer work of Van Slyke and Meyer in 1913. The reviews in this volume will show that it steadily becomes a larger aspect of amino acid metabolism, broadly perceived. These chapters will show for how many organelles, cells, tissues, organs and organ systems, the transmembrane compartmentations and flows of amino acids play very large parts in their fundamental biological relations. The authors here are tending collectively to evaluate an understanding of amino acid flows across biomernbranes, and the regulation of these flows, as necessary to an ultimate understanding of the full range of development and metabolism. Such an understanding goes far beyond the purely substrate-destabilizing contributions by enzymes, which have often been arbitrarily limited to that conceptual entity, "the cell", and which for so long a splendid time had most of biochemical research attention.

Product Details

ISBN-13:	9780306443596
Publisher:	Springer US
Publication date:	01/31/1993
Edition description:	1992
Pages:	318
Product dimensions:	7.01(w) x 10.00(h) x 0.39(d)

Table of Contents

General Aspects: Amino Acid Transporters (G.G. Guidotti, G.C. Gazzola). Techniques Used in the Study of Plasma Membrane Amino Acid Transport (J.D. McGivan). Amino Acid Transport During Embryogenesis (L.J. Van Winkle). Amino Acid Transport by Lysosomes (R.L. Pisoni, J.A. Schneider). Amino Acid Transport, Cell Volume, and Regulation of Cell Growth (D. Häussinger). Tissue Specific Transport and Functional Implications: Amino Acid Transport in Liver (M.S. Kilberg, D. Häussinger). Amino Acid Transport in Intestine (B.R. Stevens). Amino Acid Transport in Brain (Q.R. Smith, A.J.L. Cooper). Muscle Amino Acid Metabolism and Transport (B. Mackenzie et al.). Amino Acid Transport in the Kidney (J.S. Schwegler et al.). Amino Acid Transport in Lymphocytes (G.B. Segal). Interorgan Glutathione Transport (T.P.M. Akerboom, H. Sies). 5 additional articles. Index.

Editorial Reviews

The proceedings of a German Society of Biological Chemistry Conference on Coordinate Regulation between Transport and Metabolism of Glutamine, Glutamate, and Gamma-Glutamyl Compounds, held in May 1990, in Titisee, Germany. Reports of research in physiology, biochemistry, molecular biology, and medicine, examine such topics as the methodology for assessing amino acid transport systems, their energetics, the specific features of amino acid transport in different subcellular organelles and tissues, and the functional consequences and physiological importance. The 17 papers should interest biochemists, physiologists, cell biologists, students in those fields, and physicians. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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