Management of Treatment-Resistant Major Psychiatric Disorders

by Charles B. Nemeroff (Editor)

Overview

Although there are a variety of textbooks and manuals of psychiatric disorders, few have focused on the management of treatment-resistant patients. Those that exist have largely focused on treatment-resistant depression and even these are now largely outdated. Because psychiatrists and other mental health care professionals increasingly manage patients who fail treatment from family practitioners and other non-psychiatric specialists, a single practical volume summarizing the evidence-based medicine as well as the art of managing treatment-resistant patients is a much needed volume for practitioners, psychiatry residents and other mental health workers. Most importantly, both psychopharmacological and psychotherapeutic interventions will be included, a shortcoming of many previous volumes.

"Management of Treatment Resistant Major Psychiatric Disorders" contains chapters authored by leaders in the field on the management of the major treatment resistant psychiatric disorders.

Product Details

ISBN-13:	9780199739981
Publisher:	Oxford University Press
Publication date:	06/05/2012
Pages:	384
Product dimensions:	7.10(w) x 10.00(h) x 1.20(d)

About the Author

Dr. Nemeroff was born in New York City in 1949 and educated in the New York City Public School System. After graduating from the City College of New York in 1970, he enrolled in graduate school at Northeastern University and received a Master's degree in Biology in 1973. He received his MD and PhD (Neurobiology) from the University of North Carolina at Chapel Hill. His residency training in psychiatry was conducted at both the University of North Carolina and at Duke University, after which he joined the faculty of Duke University. At Duke he was Professor of Psychiatry and Pharmacology and Chief of the Division of Biological Psychiatry before relocating in 1991 to Emory University School of Medicine in Atlanta, Georgia, where he served as the Reunette W. Harris Professor and Chairman of the Department of Psychiatry and Behavioral Sciences until 2008. In 2009 he joined the University of Miami Leonard M. Miller School of Medicine as the Leonard M. Miller Professor and Chairman of the Department of Psychiatry and Behavioral Sciences. His research has concentrated on the biological basis of the major neuropsychiatric disorders, including affective disorders, schizophrenia, and anxiety disorders. His clinical research is focused on the use of genetic, neuroendocrine, neuroimaging and neurochemical methods to comprehensively understand the pathophysiology of depression. In recent years he has uncovered the neurobiological mechanisms that mediate the increased risk for depression in victims of child abuse. He has also contributed to seminal findings in the burgeoning area of research concerning the relationship of depression to cardiovascular disease.

Table of Contents

Chapter 1. The Problem of Treatment-Resistant Major Psychiatric Disorders
Charles B. Nemeroff and Patricio Riva Posse

Chapter 2. Management of Treatment-Resistant Depression: Psychopharmacology and Psychotherapy
Michael E. Thase and K. Ryan Connolly

Chapter 3. Management of Treatment-Resistant Depression - Somatic-Non-pharmacological Strategies
Paul E. Holtzheimer

Chapter 4. Management of Treatment-Resistant Bipolar Disorder
Mark A. Frye

Chapter 5. Management of Treatment-Resistant Panic Disorder
Robert Bruce Lydiard

Chapter 6. Management of Treatment-Resistant Post-Traumatic Stress
Disorder
Dan J. Stein and Kerry-Ann Louw

Chapter 7. Management of Treatment-Resistant Social Anxiety Disorder
Eric Bui and Mark H. Pollack

Chapter 8. Management of Treatment-Resistant Generalized Anxiety Disorder
Victoria Osman-Hicks, John Potokar, and David J. Nutt

Chapter 9. Management of Treatment-Resistant Obsessive-Compulsive Disorder
Robert Hudak, Priya Gopalan, and Darin D. Dougherty

Chapter 10. Management of Treatment-Resistant Anorexia Nervosa
Enrica Marzola, Mary Ellen Trunko, Emily Grenesko-Stevens and Walter H. Kaye

Chapter 11. Management of Treatment-Resistant Schizophrenia
Jacob S. Ballon and Jeffrey A. Lieberman

Chapter 12. Management of Treatment-Resistant Substance and Alcohol Abuse
Kathleen T. Brady

Chapter 13. Management of Treatment-Resistant Personality Disorders
Glen O. Gabbard

Chapter 14. Management of Treatment-Resistant Insomnia
Karl Doghramji and Charles F. Reynolds III

Chapter 15. Management of Treatment-Resistant Childhood Disorders
Karen Dineen Wagner

Editorial Reviews

Reviewer: Aaron John Plattner, MD (Network180 )
Description: Through the contributions of various leaders in psychiatry, this book describes the approach to patients with treatment-resistance psychiatric disorders.
Purpose: A high percentage of psychiatric treatment is provided by family practitioners and other nonspecialists who then refer patients to psychiatrists and other mental health providers after patients fail first- or even second-line treatment. With this understanding, the book covers the treatment approaches to several psychiatric conditions that do not respond to initial treatment. This book is vital because of the volume of research in this area and the resulting need for updated treatment approaches for diseases that are affecting a great number of people.
Audience: The editor describes this book as "a must have for practitioners, psychiatric residents, and other mental health workers." While any healthcare provider may benefit from this book, those who are referred patients likely will make the best use of it. It is helpful largely due to the editor's choice of authors who are leaders in their particular areas.
Features: The book appropriately begins by addressing the problem of treatment resistant psychiatric conditions before covering the different psychiatric disorders, including depression, bipolar disorder, schizophrenia, anxiety disorders, personality disorders, insomnia, substance abuse disorders, anorexia/bulimia, and childhood mood disorders. Each chapter uses charts, tables, and graphs to illustrate the information and ends with references.
Assessment: I have read books addressing specific psychiatric diseases, and they often cover the problem of treatment resistance of that specific condition, but this book is outstanding because it covers all the major psychiatric conditions. Further, each chapter manages to efficiently condense a large amount of information into a manageable presentation that is practical for readers. I appreciate how the book illustrates various treatment options, along with detailed pharmacological treatments. I look forward to future editions as research continues into additional treatment options.

Doody's Review Service

"Poor response, non-response and lost response to treatment in major psychiatric disorders are the rule, not the exception. The challenge of treatment resistance is foundational to the practice of clinical psychiatry. Charlie Nemeroff has gifted the field with a masterful and authoritative volume that goes well beyond algorithms and recipes for next step treatment and provides evidence-based disquisition of the heterogeneous contributors to treatment resistance, and thus drives thoughtful differential diagnosis and treatment planning. This is an essential volume for modern psychiatric practice and clinical research." — Jerrold F. Rosenbaum, MD, Chief of Psychiatry, Massachusetts General Hospital, Stanley Cobb Professor of Psychiatry, Harvard Medical School

"This book has something for everyone, from the student to the expert. A critical and ubiquitous aspect of psychiatric practice - treatment resistance - is comprehensively addressed in a scholarly yet practical fashion. Descriptions of the phenomenology and neurobiology of each of the many disorders considered are lucid, up to date, and state of the art. This is a terrific text." — David R. Rubinow, MD, Assad Meymandi Professor and Chair of Psychiatry, University of North Carolina at Chapel Hill, School of Medicine

"Unfortunately, many patients with psychiatric disorders do not respond to initial therapy. Refractory or treatment resistance is a major problem for many patients and all treaters. This superb book consists of 15 chapters—authored by leaders in the field— on the issue of resistance in the major psychiatric disorders. The chapters provide sophisticated but readable overviews of the problems encountered in treating patients with all of the major disorders and in the best evidence for overcoming them. It is unique because it emphasizes resistance across all classes of psychiatric syndromes and it thoughtfully includes both somatic and psychosocial approaches. This is a must have volume for all mental health practitioners. " — Alan F. Schatzberg, MD, Kenneth T. Norris, Jr. Professor of Psychiatry & Behavioral Science, Stanford University School of Medicine

"...this book is outstanding because it covers all the major psychiatric conditions. Further,
each chapter manages to efficiently condense a large amount of information into a manageable presentation that is practical for readers. I appreciate how the book illustrates various treatment options, along with detailed pharmacological treatments." — Aaron Plattner, MD, Pine Rest Christian Mental Health Services, Doody's

"It provides quite extensive, clear and updated information on the management of various treatment-resistant psychiatric disorders, highlighting future treatment options currently under research. I am sure psychiatrists will find it practical and useful." — Amit Jain, The Psychiatrist

"This book, containing a state-of-the-art review of how to manage treatment resistance in 15 different psychiatric disorders, is a timely gift to clinicians who have to manage patients with unremitting mental disorders. It is an excellent resource that belongs on the bookshelf of not only psychiatrists and psychiatric nurse practitioners but also other mental health professionals... Overall, I urge every reader to own this book and use it as a practical reference for the many treatment-resistant or refractory patients in clinical practice. It will save hundreds of hours of browsing PubMed to access all of the data between the covers of this timely volume!" —Journal of Clinical Psychiatry

"Given that most psychiatric disorders are chronic and relapsing, this book represents an unusually practical text that combines standard treatment protocols with less conventional but eminently usable treatment suggestions for recalcitrant symptoms. All practicing psychiatrics and more advanced trainees can benefit from having this book on their shelf." —American Journal of Psychiatry

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