Manual of Biological Markers of Disease / Edition 1

by Martin A. M. van Venrooij, R. N. Maini

Overview

Section A: Methods of Autoantibody Detection This Section provides well structured prools for autoantibody detection. Step-by-step procedures are accompanied by explanatory notes and comments, clear diagrams, line illustrations and excellent photo illustrations. Extensive literature references lead the way to further background information. The methods presented were validated by more than 40 leading laboratories active in sera analysis, which indicates that these methods have been found to be practically useful and lead to consistent inter-laboratory results: consensus in autoantibody detection. Section B: Autoantigens This Section contains the first compilation of full, detailed information on autoantigens related to important autoimmune diseases. The chapters are all structured according to an easy-reference fixed template structure: specific detection methods, cellular localization, biochemical characteristics, function, cDNA and derived amino acid sequence, gene structure, B- and T-cell epitopes and lists of published monoclonal antibodies. The text is greatly enhanced by many beautiful schematic figures and photo illustrations. As in Section A, extensive literature references are provided. The information for this section was brought together by leading experts in their fields. This Manual is an ideal text and reference book for bench scientists working in the field of autoimmunity, but also for rheumatologists, general (internal medicine) physicians or clinical immunologists caring for patients with autoimmune disorders.

Product Details

ISBN-13:	9780792342427
Publisher:	Springer-Verlag New York, LLC
Publication date:	01/28/1997
Edition description:	New Edition
Pages:	744
Product dimensions:	6.14(w) x 9.21(h) x 1.25(d)

Editorial Reviews

A series of studies associated with the European Consensus Workshop on Autoantibodies in Rheumatic Diseases designed to examine the level of agreement in autoantibody specifities reported by participating laboratories. Provides step-by-step protocols for autoantibody detections, along with explanatory notes and comments, diagrams, line drawings, and photographs. They have been validated by more than 40 laboratories active in sera analysis. Among the methods described are immunofluorescence, immunodiffusion, protein blotting, ELISA, and immunoprecipitation. Also compiles detailed information on autoantigens relating to important autoimmune diseases, including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, and myositis. No index. Annotation c. by Book News, Inc., Portland, Or.

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