Maspin / Edition 1

by Mary J.C. Hendrix

Overview

This book represents the first compilation of the major research findings regarding Maspin—a mammary serpin (or serine) protease inhibitor. Maspin was originally discovered through subtractive hybridization and differential display analyses, comparing the differences in gene expression in normal mammary epithelium and invasive carcinoma cells. This work originated in the laboratory of Dr. Ruth Sager, a world-renowned geneticist, at the Dana Farber Cancer Institute and Harvard Medical School. The first introduction of Maspin to the research community occurred as a report in Science (v263:526-529, 1994), and described the unique tumor-suppressing activity of this novel gene in human mammary epithelial cells.

Product Details

ISBN-13:	9781587060977
Publisher:	Taylor & Francis
Publication date:	08/01/2002
Series:	Medical Intelligence Unit Series
Pages:	132
Product dimensions:	9.20(w) x 6.30(h) x 0.60(d)

About the Author

Mary J.C. Hendrix, Department of Anatomy and Cell Biology Holden Comprehensive Cancer Center The University of Iowa Iowa City, Iowa, U.S.A.

Table of Contents

Preface 1. Ruth Sager, Geneticist 2. Maspin in the Sager Laboratory 3. Maspin: Functional Insights from a Structural Perspective 4. Maspin and Myoepithelial Cells 5. Maspin and Pericellular Plasminogen Activationin Cell-Matrix Interaction 6. Genetic and Epigenetic Regulation of Maspin Gene Expression in Normal and Tumor Tissue 7. Maspin Suppresses Breast Cancer Cell Invasiveness by Modulating Integrin Expression and Function 8. The Role of Maspin in Tumor Progression and Normal Development 9. The Role of Maspin in Human Placental Development 10. Maspin, a Potential Prognostic Marker for Human Cancers

Editorial Reviews

This brief volume contains ten papers presenting research findings on maspin—a mammary serpin (or serine) protease inhibitor. Focusing on the work of geneticist Ruth Sager, the book addresses functional aspects of maspin, its relationship to myopithelial cells, pericellular plasminogen activation, epigenetic regulation of gene expression, the suppression of breast cancer cell invaseness, tumor progression, human placental development, and the use of maspin as a prognostic marker. Graphs, charts, diagrams, and other black- and-white images illustrate the text. Annotation c. Book News, Inc., Portland, OR (booknews.com)