Matrix Metalloproteinases In Health And Disease: Sculpting The Human Body

by Constance E Brinckerhoff

Overview

The biochemistry and cell biology of Matrix Metalloproteinases (MMPs) are not necessarily straightforward, but basic information on the history of these enzymes, their various functions that extend far beyond the cleaving of the extracellular matrix, and the complex mechanisms that control their expression are valuable to both scientists and clinicians. This volume summarizes the salient features and functions of MMPs and applies this information in a practical manner in order to understand how they contribute to normal physiology and pathology of selected diseases. Chapters by noted clinicians Jean-Michel Dayer, MD in rheumatology, Jian Cao, MD in oncology, and Peter Libby, MD in cardiology, represent important practical and clinically-oriented contributions.

Product Details

ISBN-13:	9789813207547
Publisher:	World Scientific Publishing Company, Incorporated
Publication date:	06/14/2017
Pages:	296
Product dimensions:	6.00(w) x 9.10(h) x 0.70(d)

Table of Contents

Acknowledgments vii

Preface ix

Chapter 1 A Brief Introduction to Proteinases Constance E. Brinckerhoff 1

Chapter 2 Historical Perspective Constance E. Brinckerhoff 13

Chapter 3 Regulation of Matrix Metalloproteinase (MMP) Gene Expression Constance E. Brinckerhoff 31

Chapter 4 "Matrix Metalloproteinases: They're Not Just for Matrix Anymore!" Constance E. Brinckerhoff 65

Chapter 5 Matrix Metalloproteinases (MMPs) in Homeostasis and Health: Can MMPs be Good for You? Constance E. Brinckerhoff 95

Chapter 6 Matrix Metalloproteinases (MMPs) and Cytokines in Rheumatology Jean-Michel Dayer Samantha J. Williamson Adam P. Croft Christopher D. Buckley Carlo Chizzolini 123

Chapter 7 Matrix Metalloproteinases (MMPs) as Cancer Therapeutic Targets Jillian Cathcart Vincent M. Alford Jian Cao 157

Chapter 8 Matrix Metalloproteinases in Cardiovascular Diseases Merry L. Lindsey Peter Libby 187

Chapter 9 Matrix Metalloproteinases (MMPs) as Therapeutic Targets Constance E. Brinckerhoff 227

Chapter 10 Through the Looking Glass into the Era of Precision Medicine Constance E. Brinckerhoff 253

Glossary 267

Index 277