Table of Contents
FOREWORD xv
PREFACE xvii
ACKNOWLEDGMENTS xix
REVIEW PANEL xxi
PART 1 FOODBORNE and MICROBIAL TOXINS 1
I Chemical Contamination and Additives 5by Cyrus Rangan, MD, FAAP
1 Food Contamination 5
2 Food Additives and Sensitivities 22
II Staples and Spices 34
3 Akee Fruit and Jamaican Vomiting Sickness (Blighia sapida Köenig) 34
4 Cinnamon (Cinnamomum Species) 39
5 Cyanogenic Foods (Cassava, Fruit Kernels, and Cycad Seeds) 44
6 Cycad Seeds and Chronic Neurologic Disease (Cycas Species) 54
7 Djenkol Bean [Archidendron jiringa (Jack) I. C. Nielsen] 59
8 Grass Pea and Neurolathyrism (Lathyrus sativus L.) 62
9 Nutmeg (Myristica fragrans Houtt.) 67
10 Pepper and Capsaicin (Capsicum and Piper Species) 71
11 Potatoes, Tomatoes, and Solanine Toxicity (Solanum tuberosum L., Solanum lycopersicum L.) 77
12 Rhubarb and Oxalosis (Rheum Species) 84
III Microbes 89
A Bacteria 89by Cyrus Rangan, MD, FAAP
13 Bacillus cereus 89
14 Campylobacter jejuni 96
15 Clostridium botulinum (Botulism) 103
16 Clostridium perfringens 114
17 Escherichia coli 120
18 Listeria monocytogenes 133
19 Salmonella 141
20 Shigella Species (Shiga Enterotoxins) 150
21 Staphylococcus aureus 156
22 Streptococcus Species 162
23 Vibrio Species 167
24 Yersinia enterocolitica 174
B Other Microbes 181
25 Cyanobacteria 181
26 Protozoa and Intestinal Parasites 191
27 Gastrointestinal Viruses 202
IV Seafood 212
28 Amnesic Shellfi sh Poisoning and Domoic Acid 212
29 Azaspiracid Shellfi sh Poisoning and Azaspiracid Toxins 218
30 Diarrhetic Shellfi sh Poisoning and Okadaic Acid 222
31 Neurotoxic Shellfi sh Poisoning and Brevetoxins 227
32 Paralytic Shellfi sh Poisoning and Saxitoxins 231
33 Ciguatera Fish Poisoning and Ciguatoxins 238
34 Puffer Fish Poisoning and Tetrodotoxin 247
35 Red Whelk and Tetramine 253
36 Scombroid Fish, Scombrotoxin, and Histamine 256
PART 2 FUNGAL TOXINS 261
I Mushrooms 265
37 Amatoxin-Containing Mushrooms 265
38 False Morel and Gyromitrin Poisoning 285
39 Gastroenteritis-Producing Mushrooms 290
40 Inky Cap and Coprine Toxicity [Coprinus atramentarius (Bull.) Fr.] 294
41 Isoxazole-Containing Mushrooms and Pantherina Syndrome (Amanita muscaria, Amanita pantherina) 298
42 Muscarine-Containing Mushrooms and Muscarine Toxicity (Clitocybe and Inocybe Species) 303
43 Orellanine-Containing Mushrooms and Nephrotoxicity (Cortinarius Species) 307
44 Paxillus and Other Mushroom Syndromes 312
II Mycotoxins 317
45 Mycotoxins 317
PART 3 MEDICINAL HERBS and ESSENTIAL OILS 373
I Medicinal Herbs 377
46 Aloe Vera [Aloe vera (L.) Burm. f.] 377
47 Aristolochic Acid and Chinese Herb Nephropathy 382
48 Black Cohosh (Actaea racemosa L.) 388
49 Blue Cohosh [Caulophyllum thalictroides (L.) Michx.] 394
50 Borage (Borago offi cinalis L.) 397
51 Burdock Root (Arctium lappa L.) 400
52 Calamus (Acorus calamus L.) 403
53 Camphor (Cinnamomum camphora T. Nees & Eberm.) 407
54 Cascara (Frangula purshiana Cooper) 414
55 Cat’s Claw [Uncaria tomentosa (Willd. ex Schult.) DC.] 421
56 Chamomile [Chamomilla recutita (L.) Rauschert, Chamaemelum nobile L.] 425
57 Chaparral [Larrea tridentata (Sesse & Moc. ex DC.) Vail] 429
58 Chaste Tree (Vitex agnus-castus L.) 434
59 Clove and Eugenol [Syzygium aromaticum (L.) Merr. & L. M. Perry] 437
60 Colocynth [Citrullus colocynthis (L.) Schrad.] 443
61 Coltsfoot (Tussilago farfara L.) 446
62 Comfrey and Other Pyrrolizidine-Containing Plants 449
63 Cranberry (Vaccinium macrocarpon Aiton) 458
64 Dong Quai [Angelica sinensis (Oliv.) Diels] 461
65 Feverfew (Tanacetum parthenium Schultz Bip.) 465
66 Garlic (Allium sativum L.) 470
67 Germander (Teucrium chamaedrys L.) 477
68 Ginger (Zingiber offi cinale Roscoe) 482
69 Ginkgo Tree (Ginkgo biloba L.) 488
70 Ginseng 497
71 Goldenseal (Hydrastis canadensis L.) 504
72 Hawthorn (Crataegus Species) 510
73 Impila, Pine Thistle, and Atractyloside 514
74 Jin Bu Huan and Tetrahydropalmatine 518
75 Juniper (Juniper communis L.) 522
76 Kava (Piper methysticum Forster) 525
77 Lavender (Lavandula Species) 532
78 Licorice (Glycyrrhiza Species) 537
79 Ma Huang (Ephedra Alkaloids) 545
80 Milk Thistle [Silybum marianum (L.) Gaertner] 553
81 Passionflower (Passiflora incarnata L.) 558
82 Pennyroyal and Pulegone (Mentha pulegium L.) 563
83 Purple Coneflower and Other Echinacea Species 568
84 Rosemary (Rosmarinus offi cinalis L.) 574
85 Rue (Ruta graveolens L.) 579
86 Sassafras [Sassafras albidum (Nutt.) Nees] 582
87 Saw Palmetto [Serenoa repens (Bartram) J.K. Small] 586
88 Senna (Senna alexandrina P. Mill.) 591
89 Skullcap (Scutellaria lateriflora L.) 596
90 St. John’s Wort (Hypericum perforatum L.) 600
91 Star Anise (Illicium verum Hook. F. and Illicium anisatum L.) 607
92 Star Fruit (Averrhoa carambola L.) 611
93 Tansy (Tanacetum vulgare L.) 614
94 Valerian (Valeriana offi cinalis L.) 617
95 Yarrow (Achillea millefolium L.) 623
96 Yohimbe Bark and Yohimbine (Pausinystalia yohimbe Pierre ex Beille) 627
II Essential Oils 632
97 Citronella Oil [Cymbopogon nardus (L.) Rendle] 632
98 Citrus Oil and Limonene 635
99 Eucalyptus Oil (Eucalyptus Species) 644
100 Neem Oil (Margosa Oil) (Azadirachta indica Adr. Juss.) 648
101 Peppermint Oil (Mentha x piperita L.) 653
102 Tea Tree Oil (Melaleuca Species) 658
103 Tung Oil (Aleurites fordii Hemsl.) 663
104 Turpentine and Pine Oil (Pinus Species) 666
PART 4 TOXIC PLANTS 673
I Plant Dermatitis 677
105 Plant Dermatitis 677
II Bulbs, Rhizomes, and Tubers 690
106 Buttercup Family 690
107 Colchicine-Containing Plants 693
108 Daffodils and Other Emetic Bulbs 703
109 Death Camas 707
110 Kaffir Lily [Clivia miniata (Lindley) Bosse] 710
111 Snowdrop (Galanthus nivalis L.) 712
112 Zephyr Lily (Zephyranthes Species) 716
III Beans 718
113 Castor Bean and Ricin (Ricinus communis L.) 718
114 Cowitch and Horse Eye Bean (Mucuna Species) 727
115 Jequirity Bean and Abrin (Abrus precatorius L.) 729
116 Mescal Bean [Sophora secundiflora (Ortega) Lagasca ex DC.] 733
IV Nonwoody Plants (Herbs) 736
117 Aconite Poisoning and Monkshood 736
118 African Blue Lily (Agapanthus Species) 743
119 Red Baneberry [Actaea rubra (Aiton) Willd.] 745
120 Begonias 747
121 Yellow Bird-of-Paradise [Caesalpinia gilliesii (Hook.) Wallich ex D. Dietr.] 749
122 Century Plant (Agave americana L.) 751
123 Cleistanthin, Diterpene Esters, and the Spurge Family (Euphorbiaceae) 754
124 Cyanogenic Plants and Laetrile® 760
125 Dieffenbachia and Other Oxalate-Containing House Plants 768
126 Digitalis-Containing Flowers (Foxglove, Lily of the Valley) 773
127 Jimson Weed and Other Belladonna Alkaloids 776
128 Lupines and False Lupine 784
129 Mayapple (Podophyllum peltatum L.) 788
130 Mistletoe 792
131 Poison Hemlock (Conium maculatum L.) 796
132 Pokeweed (Phytolacca americana L.) 800
133 European Bittersweet and Other Solanum Species 803
134 Sweet Pea and Osteolathyrism 806
135 Tree Tobacco and Other Piperidine-Containing Plants 809
136 Veratrum Alkaloids 815
137 Wandering Jew (Tradescantia fl uminensis Vellozo) 819
138 Water Hemlock and Water Dropwort 821
139 White Snakeroot [Ageratina altissima (L.) King & H.E. Robins] 826
V Shrubs and Vines 829
140 Barbados Nut (Jatropha curcas L.) 829
141 Boxwood (Buxus sempervirens L.) 832
142 Buckthorn [Karwinskia humboldtiana (J.A. Schultes) Zucc.] 834
143 Cactus 837
144 Carolina Jessamine [Gelsemium sempervirens (L.) St. Hil.] 841
145 Daphne (Daphne mezereum L.) 843
146 Dog Laurel (Leucothoe Species) 845
147 Dogbane Family and Cardenolides 847
148 Holly (Ilex Species) 861
149 Honeysuckle (Lonicera Species) 863
150 Ivy and Falcarinol 865
151 Lantana (Lantana camara L.) 867
152 Rhododendrons and Grayanotoxins 870
153 Snowberry [Symphoricarpos albus (L.) Blake)] 874
154 Squirting Cucumber [Ecballium elaterium (L.) A. Richard] 876
155 Wisteria 879
VI Trees 881
156 Black Locust (Robinia pseudoacacia L.) 881
157 Buckeye (Aesculus Species) 883
158 Chinaberry (Melia azedarach L.) 886
159 Golden Chain Tree (Laburnum anagyroides Medikus) 889
160 Karaka Nut (Corynocarpus laevigatus J.R. & G. Forst.) 892
161 Oaks (Quercus Species) 894
162 Pepper Tree (Schinus Species) 897
163 Yew (Taxus Species) 899
PART 5 VENOMOUS ANIMALS 905
I Arthropods 909
A Arachnids 909
164 Mites and Ticks (Order: Acari) 909
165 Scorpions (Order: Scorpiones) 914
166 Spiders (Order: Araneae) 925
B Centipedes 950
167 Centipedes (Subclass: Chilopoda) 950
C Insects 954
168 Bees, Wasps, and Ants (Order: Hymenoptera) 954
169 Bugs and Blister Beetles 969
170 Fleas (Order: Siphonaptera) 976
171 Flies and Mosquitoes (Order: Diptera) 979
172 Lice (Order: Phthiraptera) 983
173 Moths and Butterflies (Order: Lepidoptera) 988
II Reptiles 996
174 Amphibians—Toads, Frogs, Salamanders, and Newts (Class: Amphibia) 996
175 Gila Monster and Beaded Lizard 1008
176 Terrestrial Snakes (Suborder: Serpentes) 1013
177 Sea Snakes 1074
III Marine Invertebrates 1078
178 Cone Shells and Blue-Ringed Octopus (Phylum: Mollusca) 1078
179 Jellyfish, Hydroids, Sea Anemones, and Corals (Phylum: Cnidaria) 1085
180 Sponges (Phylum: Porifera) 1102
181 Starfish, Sea Urchins, Sea Cucumbers, and Fireworms (Phylum: Echinodermata) 1105
IV Eels and Lampreys 1112
182 Moray Eel (Superclass: Agnatha) 1112
V Fish 1115
183 Bony Fish (Class: Osteichthyes) 1115
184 Cartilaginous Fish (Class: Chondrichthyes) 1128
VI Mammals 1132
185 Mammals 1132
INDEX 1135