Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis: Methods for Quantitative Synthesis in Medicine / Edition 2

by Diana B. Petitti

Overview

Meta-analysis, decision analysis, and cost-effectiveness analysis are the cornerstones of evidence-based medicine. These related quantitative methods have become essential tools in the formulation of clinical and public policy based on the synthesis of evidence. All three methods are taught with increasing frequency in medical schools and schools of public health and in health policy courses at the undergraduate and graduate level. This book is a lucid introduction, and will serve the needs of students taking introductory courses that cover these topics. It will also be useful to clinicians and policymakers who need to understand the quantitative underpinnings of the methods in order to best apply the information that derives from them. The second edition of this popular book adds new material on cumulative meta-analysis as a method to explore heterogeneity. The coverage of cost-effectiveness analysis has been brought into close alignment with recommendations of the U.S. Public Health Panel on Cost-Effectiveness Analysis in Health and Medicine. Many of the examples have been replaced with more current examples, and all of the material has been updated to reflect recent advances in the methods and the emergence of consensus about some previously controversial issues. analysis. These three closely related methods have become even more important for synthesizing research since the first edition was published in 1994. And they have gained legitimacy as tools for guiding health policy.

Product Details

ISBN-13:	9780195133646
Publisher:	Oxford University Press
Publication date:	10/14/1999
Series:	Monographs in Epidemiology and Biostatistics , #31
Edition description:	REV
Pages:	320
Product dimensions:	9.44(w) x 6.48(h) x 1.06(d)

About the Author

Petitti, Diana B., MD, MPH (Kaiser Permanente Southern California)

Table of Contents

1. Introduction2. Overview of the Methods3. Planning the Study4. Information Retrieval5. Data Collection6. Advanced Issues in Meta-Analysis7. Statistical Methods in Meta-Analysis8. Other Statistical Issues in Meta-Analysis9. Complex Decision Problems10. Estimating Probabilities11. Utility Analysis12. Advanced Cost Effectiveness Analysis13. Utility and Cost-Utility Analysis14. Exploring Heterogeneity15. Sensitivity Analysis16. Reporting Results17. Limitations

Editorial Reviews

Reviewer: Patricia Langenberg, PhD (University of Maryland at Baltimore School of Medicine)
Description: This book is a comprehensive review of meta-analysis, decision analysis, and cost-effectiveness analysis as quantitative methods for the synthesis of research information in medicine.
Purpose: The purpose is to describe methods of meta-analysis, decision analysis, and cost effectiveness analysis in order to summarize information from the literature in medicine. The objectives are particularly worthy in that the subjects are controversial and books on the topic have heretofore been primarily statistical or geared toward literature in fields other than medicine.
Audience: The book is very well written and accessible to nearly anyone in the medical field who would contemplate either reading about or carrying out meta-analysis, decision analysis, or cost-effectiveness analysis. The author is highly knowledgeable about her subject.
Features: All stages of meta-analysis are covered: data retrieval/collection, detection of bias, statistical analysis, exploration of heterogeneity. Many relevant examples from the field of medicine are cited and examples of the statistical methods are provided. More important, space is devoted to the difficulties of identifying the 'fugitive' studies that may introduce serious bias (publication bias) if not included, since they are more likely to have negative results. Decision analysis methods are also described, including identification of the problem and its components structuring decision trees, estimation of probabilities, and sensitivity analysis. Decision analysis is described as the cornerstone of cost effectiveness analysis with the addition of cost data, identification of outcomes, and choice of cost-benefit function.
Assessment: This book is very well written, easy to understand and apply, with excellent relevant examples. It is the most comprehensive and accessible book in this field.

Doody's Review Service

Reviewer: Patricia Langenberg, PhD(University of Maryland at Baltimore School of Medicine)
Description: This book is a comprehensive review of meta-analysis, decision analysis, and cost-effectiveness analysis as quantitative methods for the synthesis of research information in medicine.
Purpose: The purpose is to describe methods of meta-analysis, decision analysis, and cost effectiveness analysis in order to summarize information from the literature in medicine. The objectives are particularly worthy in that the subjects are controversial and books on the topic have heretofore been primarily statistical or geared toward literature in fields other than medicine.
Audience: The book is very well written and accessible to nearly anyone in the medical field who would contemplate either reading about or carrying out meta-analysis, decision analysis, or cost-effectiveness analysis. The author is highly knowledgeable about her subject.
Features: All stages of meta-analysis are covered: data retrieval/collection, detection of bias, statistical analysis, exploration of heterogeneity. Many relevant examples from the field of medicine are cited and examples of the statistical methods are provided. More important, space is devoted to the difficulties of identifying the 'fugitive' studies that may introduce serious bias (publication bias) if not included, since they are more likely to have negative results. Decision analysis methods are also described, including identification of the problem and its components structuring decision trees, estimation of probabilities, and sensitivity analysis. Decision analysis is described as the cornerstone of cost effectiveness analysis with the addition of cost data, identification of outcomes, and choice of cost-benefit function.
Assessment: This book is very well written, easy to understand and apply, with excellent relevant examples. It is the most comprehensive and accessible book in this field.

This book is a comprehensive review of meta-analysis, decision analysis, and cost-effectiveness analysis as quantitative methods for the synthesis of research information in medicine. The purpose is to describe methods of meta-analysis, decision analysis, and cost effectiveness analysis in order to summarize information from the literature in medicine. The objectives are particularly worthy in that the subjects are controversial and books on the topic have heretofore been primarily statistical or geared toward literature in fields other than medicine. The book is very well written and accessible to nearly anyone in the medical field who would contemplate either reading about or carrying out meta-analysis, decision analysis, or cost-effectiveness analysis. The author is highly knowledgeable about her subject. All stages of meta-analysis are covered: data retrieval/collection, detection of bias, statistical analysis, exploration of heterogeneity. Many relevant examples from the field of medicine are cited and examples of the statistical methods are provided. More important, space is devoted to the difficulties of identifying the 'fugitive' studies that may introduce serious bias (publication bias) if not included, since they are more likely to have negative results. Decision analysis methods are also described, including identification of the problem and its components structuring decision trees, estimation of probabilities, and sensitivity analysis. Decision analysis is described as the cornerstone of cost effectiveness analysis with the addition of cost data, identification of outcomes, and choice of cost-benefit function. This book is very well written, easy to understand andapply, with excellent relevant examples. It is the most comprehensive and accessible book in this field.

Patricia Langenberg

This monograph describes three related methods on decision making and policy setting: decision analysis, cost-effectiveness analysis, and meta-analysis. The book educates the reader in appropriate use of these methods. "The purpose is to educate physicians (and others) on these three methodologies of medical decision making and policy formulation. These topics are current and important. No other book provides this joint presentation. The book effectively meets the author's objectives. "This book is appropriate for medical students (advanced), residents, physicians, and others interested in these methods, either to get a general overview or to get a basic formulation in the methods. The author is credible. "The major key references are cited. The table of contents and index are excellent. "This book provides an excellent readable general and technical introduction to these critically important methods in health care decision making and policy setting. It is useful as a monograph for individual use or as a text for courses or seminars.

Michael M. Ravitch