Models, Molecules and Mechanisms in Biogerontology: Cellular Processes, Metabolism and Diseases

by Pramod C. Rath

Overview

The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.

Product Details

ISBN-13:	9789813290044
Publisher:	Springer Nature Singapore
Publication date:	06/27/2020
Edition description:	1st ed. 2020
Pages:	497
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Pramod C. Rath is a Professor of Molecular Biology at the School of Life Sciences, Jawaharlal Nehru University, New Delhi. He received his Ph. D. in 1988 from the Banaras Hindu University. He did his post-doctoral research at the Institute for Molecular Biology I, University of Zurich, ETH-Hoenggerberg from 1989 to 1990 on “Regulation of Interferon Gene Expression in Mammalian Cells” with Prof. Charles Weissmann, Director.

He has 25 years of teaching and research experience, having mentored 17 Ph. D. and 3 M. Phil. students. He has published his research in reputed international journals, such as, Ageing Research Reviews, Molecular Neurobiology, Journal of Molecular Neuroscience, International Journal of Developmental Neuroscience, International Journal of Biological Macromolecules, RNA Biology, PLos One etc. He has published a Springer book, titled 'Topics in Biomedical Gerontology' in 2017.

He has been a recipient of several awards including the A. B. Mishra award for being the gold-medalist during his M. Sc; the Council of Scientific and Industrial Research fellowship for completing his Ph. D.; Swiss National Fund post-doctoral fellowship; Young Scientist research project of the Department of Science and Technology, Government of India, 1993-95; etc. He is a life member of many scientific bodies, including Vice-President of the Association of Gerontology, India (AGI), Indian Immunology Society (IIS), Indian Society of Cell Biology (ISCB) etc. He is a reviewer for many reputed journals, such as Cancer Investigations, DNA and Cell Biology, Indian Journal of Biochemistry and Biophysics, J Genetics, Scientific Reports (NPG), FEBS Letts, BMC Cancer (Biomed Central), Molecular Neurobiology, Neuroscience Letts, Molecular Biology Reports, e-CAM, Biomed. Res. Int., J. Cell. Biochem., Biogerontology etc. He is an Editorial Board member for Frontiers in Cell and Developmental Biology, Switzerland.

Table of Contents

I. Alterations in Cellular Mechanisms during Aging

1. Protein Structure and Function in Aging and Age-Related Diseases

2. DNA, DNA Replication and Aging

3. Transcription and Aging

4. Ribosomes, Translation and Aging

5. p53 and Aging

6. Paired box (Pax) Transcription Factors and Aging

7. Telomeres, Telomerase and Aging

8. The Epigenome of Ageing

9. Attaining Epigenetic Rejuvenation: Challenges Ahead

10. Mihondria as a Key Player in Aging

11. Aging, Free Radicals and Reactive Oxygen Species: an Evolving Concept

12. Stem cells and Aging

13. Can autophagy stop the clock: Unravelling the mystery in Dictyostelium discoideum

14. Aging: Reading, Reasoning and Resolving using Drosophila as a Model System

15. Nothobranchius furzeri as a new model system for aging studies

II. Alterations in Metabolism during Aging and Diseases

16. Aging in muscle

17. Metabolic Diseases and Aging

18. Interplay between Nutrient Sensing Molecules during Aging and Longevity

Editorial Reviews

Reviewer: Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)
Description: The book covers the basic and molecular mechanisms associated with aging, including important genetic, epigenetic, biochemical, and metabolic regulations, along with some important age-related diseases.
Purpose: The purpose is to present contemporary and cutting-edge information for basic science research and clinical situations. These are extremely worthy objectives. The book meets these objectives by providing in-depth coverage on models, molecules, and mechanisms in biogerontology.
Audience: The book is written for graduate students and basic science and clinical science researchers interested in the field of biogerontology. In addition to the audience indicated, clinicians and gerontologists will find this book of much interest, which meets the needs of its intended audience. The author is a credible authority in this field of biogerontology based on his credentials and publications.
Features: The book is divided into two parts. Part I deals with alterations in cellular mechanisms during aging and is subdivided into 15 chapters covering important topics such as telomeres, telomerase, and aging; transcription and aging; and P-53 and aging together with various model systems such as Drosophila and Nothobranchius furzeri model system for aging. Part II of the book deals with alterations in metabolism during aging and diseases. It is subdivided into six chapters covering other important topics in aging such as metabolic diseases and aging; biological rhythms and aging; and the biology of aging and cancer. Provision of an index may have greatly facilitated easy location of these important topics in biogerontology.
Assessment: This is an extremely useful book covering models, molecules, and mechanisms in biogerontology. It comprehensively describes the important, genetic, epigenetic, biochemical, and metabolic regulations during aging together with some age-related diseases. Among other books in this field, this title clearly stands out due to its comprehensive coverage of the important topics in the field of biogerontology.

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