Molecular Basis for Mitochondrial Signaling

by Tatiana K. Rostovtseva

Overview

This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mihondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mihondrial inner membrane, the mihondrial calcium uniporter and the mihondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mihondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mihondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mihondrial Signaling covers these and many more recent studies of mihondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.

Product Details

ISBN-13:	9783319856889
Publisher:	Springer International Publishing
Publication date:	08/08/2018
Series:	Biological and Medical Physics, Biomedical Engineering
Edition description:	Softcover reprint of the original 1st ed. 2017
Pages:	386
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

From the Contents: Mihondrial Calcium Signaling.- Systems approaches to mihondrial calcium signaling.- The mihondrial Calcium Uniporter: Molecular Composition And Physiological Role.- Molecular Mechanisms of Mihondrial Ca2+ Uptake.- Ca2+ uniporter and male fertility.