Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion / Edition 1

by Boris Draznin, Derek LeRoith

Overview

In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe comprehensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor­ mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre­ tion may be the crucial step in the pathogenesis of noninsulin-depen­ dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mechanisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.

Product Details

ISBN-13:	9780896032866
Publisher:	Springer-Verlag New York, LLC
Publication date:	09/02/1994
Edition description:	1994
Pages:	404
Product dimensions:	5.98(w) x 9.02(h) x 0.04(d)

About the Author

Draznin, Boris, MD, PhD (Univ of Colorado); LeRoith, Derek, MD, PhD (National Institutes of Health)

The contributors represent the specialties of clinical biochemistry, endocrinology, childhood diabetes, chemistry, internal medicine, neuro-pharmacology, cell biology, morphology, molecular physiology and biophysics. Most come from U.S. academic medical centers. Two each are from Switzerland and the U.K. One contributor is from Chile. Institutions prominently represented include Univ of Colorado, Univ of Texas, and Univ of Pennsylvania.

Table of Contents

Molecular Mechanisms of Autoimmunity and Genetics of Diabetes.- 1. Molecular Targets of the Autoimmunity of Type I Diabetes.- 2. Murine Transgenic Models of IDDM.- 3. Pancreatic Islet Transplantation.- 4. Pathogenesis of Autoimmune Diabetes.- Molecular and Cellular Aspects of Insulin Synthesis and Secretion.- 5. Insulin Gene Structure and Regulation.- 6. Molecular Engineering of Glucose-Regulated Insulin Secretion.- 7. Glucokinase Gene Expression and Regulation.- 8. Fundamentals of Fuel Sensing and Intermediary Metabolism in Pancreatic A-and B-Cells.- 9. Glucose Toxicity and the Insulin Gene.- 10. Proinsulin-Processing Endopeptidases.- 11. GTP and Its Binding Proteins in the Regulation of Insulin Exocytosis.- 12.—-Cell Receptors: Mechanisms of Signal Transduction.- 13. Molecular Biology of the Ion Channels in the Pancreatic—-Cell.- 14. Molecular Biology of Gap Junction Proteins.- 15. The Gluco-Incretin Hormone Glucagon-Like Peptide-1 and Its—-Cell Receptor.- 16. Islet Amyloid Polypeptide (IAPP) and Insulin Secretion.

Editorial Reviews

Reviewer: Kevan C. Herold, MD (Columbia University College of Physicians and Surgeons)
Description: This is the first of a new two-part series designed to review the latest in diabetes research in a comprehensive but concise manner. In this volume, the authors have invited contributions pertaining to factors affecting beta cell function, including autoimmunity, the genetics of diabetes, and molecular mechanisms of insulin synthesis and secretion. Because the field has evolved rapidly, a concise summary of the latest developments is very valuable.
Purpose: The book is written primarily for researchers and others with particular interests in the pathogenesis of diabetes. However, there is a great deal of valuable information for specialists in diabetes that has bearing on approaches to disease and future treatment. The text is not overly bogged down with experimental details, and so it would also be valuable to one interested in keeping abreast of research developments in the field. The authors and contributors are recognized authorities in the field of diabetes.
Audience: The book is easy to read, but there are relatively few illustrations. Those that are included deal primarily with presentation of data rather than summary of concepts. The references are, in general, up-to-date.
Features: In general, the book includes broadly based reviews of essential areas. Overall, the chapters are well written. However, they do tend to focus on the author's own biases, and a more balanced approach would improve the quality of the book. However, this is also a strength of this book. Each of the contributors is an outstanding researcher in the field, and has made significant contributions. Thus, the approaches taken are justified.
Assessment: This is an essential book for a medical library to have, and it is a welcome addition to the library of investigators in the field. Specialists in diabetes will also find this book very useful.

Doody's Review Service

This is an essential book for a medical library to have, and it is a welcome addition to the library of investigators in the field. Specialists in diabetes will also find this book very useful. - Kevan Herold, MD for Doody's Health Science Book Review Journal

From the Publisher

Reviewer: Kevan C. Herold, MD(Columbia University College of Physicians and Surgeons)
Description: This is the first of a new two-part series designed to review the latest in diabetes research in a comprehensive but concise manner. In this volume, the authors have invited contributions pertaining to factors affecting beta cell function, including autoimmunity, the genetics of diabetes, and molecular mechanisms of insulin synthesis and secretion. Because the field has evolved rapidly, a concise summary of the latest developments is very valuable.
Purpose: The book is written primarily for researchers and others with particular interests in the pathogenesis of diabetes. However, there is a great deal of valuable information for specialists in diabetes that has bearing on approaches to disease and future treatment. The text is not overly bogged down with experimental details, and so it would also be valuable to one interested in keeping abreast of research developments in the field. The authors and contributors are recognized authorities in the field of diabetes.
Audience: The book is easy to read, but there are relatively few illustrations. Those that are included deal primarily with presentation of data rather than summary of concepts. The references are, in general, up-to-date.
Features: In general, the book includes broadly based reviews of essential areas. Overall, the chapters are well written. However, they do tend to focus on the author's own biases, and a more balanced approach would improve the quality of the book. However, this is also a strength of this book. Each of the contributors is an outstanding researcher in the field, and has made significant contributions. Thus, the approaches taken are justified.
Assessment: This is an essential book for a medical library to have, and it is a welcome addition to the library of investigators in the field. Specialists in diabetes will also find this book very useful.

This is the first of a new two-part series designed to review the latest in diabetes research in a comprehensive but concise manner. In this volume, the authors have invited contributions pertaining to factors affecting beta cell function, including autoimmunity, the genetics of diabetes, and molecular mechanisms of insulin synthesis and secretion. Because the field has evolved rapidly, a concise summary of the latest developments is very valuable. The book is written primarily for researchers and others with particular interests in the pathogenesis of diabetes. However, there is a great deal of valuable information for specialists in diabetes that has bearing on approaches to disease and future treatment. The text is not overly bogged down with experimental details, and so it would also be valuable to one interested in keeping abreast of research developments in the field. The authors and contributors are recognized authorities in the field of diabetes. The book is easy to read, but there are relatively few illustrations. Those that are included deal primarily with presentation of data rather than summary of concepts. The references are, in general, up-to-date. In general, the book includes broadly based reviews of essential areas. Overall, the chapters are well written. However, they do tend to focus on the author's own biases, and a more balanced approach would improve the quality of the book. However, this is also a strength of this book. Each of the contributors is an outstanding researcher in the field, and has made significant contributions. Thus, the approaches taken are justified. This is an essential book for a medical library to have, and it is a welcome addition to thelibrary of investigators in the field. Specialists in diabetes will also find this book very useful.

Kevan C. Herold

The first of two volumes comprising a comprehensive survey and synthesis of current knowledge on the molecular biology of diabetes and insulin action. Part I focuses exclusively on the genetic basis of diabetes and the molecular biology of insulin synthesis, secretion, and regulation. The topics include pathogenesis of autoimmune diabetes, gene structure and regulation of insulin, and glucose toxicity and the insulin gene. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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