Molecular Biology of Hematopoiesis 5 / Edition 1

by Nader G. Abraham, Shigetaka Asano, G. Brittinger, G.J.M. Maestroni, R.K. Shadduck

Overview

This volume of Molecular Biology of Hematopoiesis is dedicated to John W. Adam­ son, M. D. , Tadamitsu Kishimoto, M. D. , Robert C. Gallo, M. D. , Arthur W. Nienhuis, M. D. , and Franco Mandelli, M. D. , for their contributions in developing an overall view of the state-of-the-art knowledge in the field of hematopoiesis. Richard Champlin, among other renowned clinicians, presented updated information on stem cells and T-cell depletion for bone marrow transplant. A clinical update on thrombopoietin was presented by Pamela Hunt of Amgen and by Kenneth Kaushansky. Arthur Nienhuis' and Katherine Turner's contributions to our current knowledge and advances in the fields of growth factors and gene transfer were also recognized during the 9th Symposium on Molecular Biology of Hematopoiesis in Genoa. The chapters cover such diverse areas as preclinical and clinical updates on growth factors and positive and negative regulatory molecules. "Advances in Leukemia: Mechanism and Treatment by Interferon" was presented by Professor Sante Tura. Readers will find presentation of exciting advances that have occurred in the area of hematopoiesis. The elucidation of gene structures of key growth factor proteins such as IL-12 and IL-II will lead to new insights and new approaches in understanding the regulation of hematopoiesis, as well as application of new growth factors.

Product Details

ISBN-13:	9781461380313
Publisher:	Springer US
Publication date:	10/01/2011
Edition description:	Softcover reprint of the original 1st ed. 1996
Pages:	737
Product dimensions:	6.69(w) x 9.61(h) x 0.06(d)

About the Author

Abraham, Nader G. (Rockefeller Univ); Asano, Shigetaka (Univ of Tokyo); Brittinger, Gunther (Universitat-Gesamthoschschule Essen); Maestroni, Georges J. M. (Instituto Cantonale di Patologia); Shadduck, Richard K. (Western Pennsylvania Cancer Institute)

The contributors represent the specialties of hematology/oncology, microbiology, molecular/cellular biology, human genetics, and hematopathology. Most are from universities, research institutes, and hospitals in 14 countries, including Italy, Germany, the U.K., and the U.S. Institutions prominently represented include Univ of Bologna, Univ of Genova, Univ of Wurzburg, Royal Victoria Infirmary, National Cancer Institute, and Rockefeller Univ.

Table of Contents

I. Advances in Bone Marrow Transplant: Stem Cells and T-Cell Depletion.- II. Clinical Update on Malignant Lymphoma and Myeloma: Mechanism/Therapy.- III. Update on Advancement in Leukemia.- IV. Update on Role of HIV and Viruses in Hematopoiesis.- V. Molecular Regulation of Hematopoietic Genes and Gene Transfer.- VI. Cytokine Action and Signal Transduction.- VII. Thrombopoiesis and Erythropoiesis: An Update.- VIII. Cytokines and Myeloproliferative Disorders.- IX. New Directions in Iron Chelating Therapy.