Molecular Carcinogenesis and the Molecular Biology of Human Cancer

by David Warshawsky (Editor), Joseph R. Landolph Jr. (Editor)

Overview

To gain a complete overview of what is presently known about molecular carcinogenesis would prove to be a very daunting task for those not already steeped in this complex subject. Providing an in-depth summary of the molecular aspects of carcinogenesis, this text comprehensively covers chemical, radiation, and viral carcinogenesis - from animal and human test data to metabolism and DNA binding. It covers organic and metal carcinogenesis related to lung, breast, prostate, skin, liver, colon, brain, and thyroid cancers. The book explores the human implications of data regarding oncogenesis of transgenic and knockout mice and rats. It also covers the genomics and proteomics of chemoprevention, risk and exposure assessments, and regulation of carcinogens. Molecular Carcinogenesis and the Molecular Biology of Human Cancer is an ideal text for graduate courses in cancer.

Product Details

ISBN-13:	9780203503430
Publisher:	CRC Press
Publication date:	10/31/2005
Sold by:	Barnes & Noble
Format:	eBook
Pages:	592
File size:	10 MB

About the Author

Warshawsky\, David; Landolph Jr.\, Joseph R.

Table of Contents

Historical Perspective and Overview. Whole Animal Carcinogenecity Bioassays: Initiation and Promotion. Classes of Carcinogens. Metabolic Activation of Chemical Carcinogens. DNA Binding of Carcinogens to DNA and Covalent Adducts and DNA Damage-Mechanisms of Carcinogenesis. Mutagenesis and Genetic Toxicology. Chemically Induced Morphological and Neoplastic Transformation. Viral Carcinogenesis. Oncogene Activation and Chemical Carcinogenesis. Tumor Suppressor Gene Inactivation and Chemical Carcinogenesis. Radiation Carcinogenesis. Overview of Human Cancer Induction and Human Exposure to Carcinogens. Lung Cancer. Skin Cancer. Other Chemically Induced Cancers. Mixtures of Chemical Carcinogens: Principles of Action and Human Exposure. Risk Assessment and Regulation of Carcinogens. Chemoprevention of Chemical Carcinogenesis and Human Cancer.