Table of Contents
Contributors — Abbreviations — Single-letter codes for amino acids Preface — 1 Basis of gene structure and function. S.M. Farrow — Introduction — Gene transcription to polypeptide synthesis — Gene transcription — Regulation of gene transcription — Post-transcriptional regulation of gene expression — Translational regulation — Concluding remarks — References — 2 Molecular analysis of gene structure and function. P.M. Brickell — Introduction — Detecting mutations in genes — Analysing the regulation of gene expression — Molecular ‘fingerprinting’ of DNA and RNA populations — Isolating differentially expressed genes by subtractive hybridization — Analysing gene function in transgenic mice — Identifying protein-protein interactions — Conclusion — References — 3 Mechanism of action of peptide hormones. S. Barker — Introduction — Receptor protein structure-function relationships — Signal transduction pathways — Regulation of the response — Future perspectives — References — 4 The steroid hormone superfamily of receptors. VK.K. Chatterjee, R.J. Clifton-Bligh and C. Matthews — Introduction — Structure-function relationships in nuclear receptors — Nuclear hormone receptor mutations and disease — Nuclear receptor knockouts — Conclusions — References — 5 Molecular insights into mechanisms regulating glucose homeostasis. PR. Shepherd — Introduction — The role of the endocrine pancreas — The role of liver, muscle and adipose tissue in the regulation of glucose homeostasis — Role of insulin-signalling pathways in maintaining glucose homeostasis — Integration of the individual components regulating glucose homeostasis — Conclusion — References — 6 PTHrP in calcium homeostasis. T.J. Martin and M. T. Gillespie — Introduction — Hypercalcaemia in cancer - the role of PTHrP — Characterization of PTHrP — The PTHrP gene — Regulation of PTHrP expression — PTH, PTHrP and calcium receptors — Tissue distribution of PTHrP - its functions as a cytokine — PTHrP and placental calcium transport — PTHrP in lactation — PTHrP in bone — Receptor-related genetic disorders — References — 7 Molecular biology of growth. W.R. Baumbach, B. Bingham and — JR. Zysk — The growth hormone axis — The hypothalamic hormones GRF and SRIF and their receptors — GH — GH receptors and binding proteins — IGF-I, its receptor and binding proteins — Concluding remarks — References — 8 Molecular biology of steroid biosynthesis. G. Rumsby — Introduction — The enzymes — Regulation of steroidogenesis — Developmental regulation of steroidogenesis — Conclusion — References — 9 Genetics of hypertension and the renin-angiotensin-aldosterone system. PC. White — Introduction — Angiotensinogen — Steroid 11 (3-hydroxylase isozymes — llp-Hydroxysteroid dehydrogenase — The amiloride-inhibitable epithelial sodium channel — References — 10 Sex differentiation, gonadal development and reproductive function.G.S. Conway — Introduction — Sex differentiation and gonadal development — The hormonal control of reproductive function — Conclusions — References — Index.
