Molecular Evolution and Phylogenetics / Edition 1

by Masatoshi Nei, Sudhir Kumar

Overview

During the last ten years, remarkable progress has occurred in the study of molecular evolution. Among the most important factors that are responsible for this progress are the development of new statistical methods and advances in computational technology. In particular, phylogenetic analysis of DNA or protein sequences has become a powerful tool for studying molecular evolution. Along with this developing technology, the application of the new statistical and computational methods has become more complicated and there is no comprehensive volume that treats these methods in depth. Molecular Evolution and Phylogenetics fills this gap and present various statistical methods that are easily accessible to general biologists as well as biochemists, bioinformatists and graduate students. The text covers measurement of sequence divergence, construction of phylogenetic trees, statistical tests for detection of positive Darwinian selection, inference of ancestral amino acid sequences, construction of linearized trees, and analysis of allele frequency data. Emphasis is given to practical methods of data analysis, and methods can be learned by working through numerical examples using the computer program MEGA2 that is provided.

Product Details

ISBN-13:	9780195135855
Publisher:	Oxford University Press
Publication date:	07/27/2000
Edition description:	New Edition
Pages:	352
Product dimensions:	9.94(w) x 7.06(h) x 0.69(d)

About the Author

Pennsylvania State University

Arizona State University

Table of Contents

Numerical Examples1. Molecular Basis of Evolution2. Evolutionary Change of Amino Acid Sequences3. Evolutionary Change in DNA Sequences4. Synonymous and Nonsynonymous Nucleotide Substitutions5. Phylogenetic Trees6. Phylogenetic Inference: Distance Methods7. Phylogenetic Inference: Maximum Parsimony Methods8. Phylogenetic Inference: Maximum Likelihood Methods9. Accuracies and Statistical Tests of Phylogenetic Trees10. Molecular Clocks and Linearized Trees11. Ancestral Nucleotide and Amino Acid Sequences12. Genetic Polymorphism and Evolution13. Population Trees from Genetic Markers14. PerspectivesAppendicesReferencesIndex