Molecular Genetics of Liver Neoplasia / Edition 1

by Xin Wei Wang, Joe W. Grisham, Snorri S. Thorgeirsson

Overview

Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepaellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy.

Product Details

ISBN-13:	9781441960818
Publisher:	Springer New York
Publication date:	11/08/2010
Series:	Cancer Genetics
Edition description:	2011
Pages:	399
Product dimensions:	6.30(w) x 9.20(h) x 1.10(d)

Table of Contents

Part I Introduction

1 Biology of Hepatocellular Carcinoma: Past, Present and Beyond Xin Wei Wang Joe W. Grisham Snorri S. Thorgeirsson 3

2 Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum Joe W. Grisham Xin Wei Wang Snorri S. Thorgeirsson 19

Part II Liver Cancer Development and Pathogenesis

3 Pathology of Hepatocellular Carcinoma Masamichi Kojiro 37

Part III Genetics and Epidemiology of Liver Cancer

4 Epidemiology of Hepatocellular Carcinoma Donna L. White Hashem B. El-Serag 51

5 Genetics and Epidemiology of Cholangiocarcinoma Boris R.A. Blechacz Gregory J. Gores 75

Part IV Molecular Basis of Cancer Susceptibility

6 Signaling Pathways in Viral Related Pre-neoplastic Liver Disease and Hepatocellular Carcinoma Jack R. Wands Miran Kim 103

7 Epigenetic Effects of Persistent Hepatitis C Virus Infection and Hepatocellular Carcinoma David R. McGivern Stanley M. Lemon 129

8 DNA Methylation Status in Chronic Liver Disease and Hepatocellular Carcinoma Yae Kanai Eri Arai 147

Part V Animal Models

9 Transgenic and Knockout Mouse Models of Liver Cancer Diego F. Calvisi Valentina M. Factor Snorri S. Thorgeirsson 163

10 Mosaic Cancer Mouse Models and Functional Oncogenomics in Hepatocellular Carcinoma Lars Zender Scott W. Lowe 189

11 The Zebrafish Model for Liver Carcinogenesis Zhiyuan Gong Chor Hui Vivien Koh Anh Tuan Nguyen Huiqing Zhan Zhen Li Siew Hong Lam Jan M. Spitsbergen Alexander Emelyanov Serguei Parinov 197

Part VI Global Gene Expression Profiling of Human Liver Cancer

12 Integrative and Functional Genomics of HCC Cédric Coulouarn Snorri S. Thorgeirsson 221

13 Molecular Signatures of Hepatocellular Carcinoma Metastasis Anuradha Budhu Xin Wei Wang 241

14 Gene Mutations and Transcriptomic Profiles Associated to Specific Subtypes of Hepatocellular Tumors Jessica Zucman-Rossi 259

Part VII Cancer Stem Cells

15 Cancer Stem Cells and Liver Cancer Jens U. Marquardt Snorri S. Thorgeirsson 279

16 Heterogeneity of Liver Cancer Stem Cells Taro Yamashita Masao Honda Shuichi Kaneko 301

17 Cancer Stem Cells in Liver Carcinoma Tania Roskams 319

Part VIII Liver Cancer Genetics in the Clinic

18 Molecular Signaling in Hepatocellular Carcinoma Hong Yang Wang Jin Ding 337

19 Molecular Events on Metastasis of Hepatocellular Carcinoma Zhao-You Tang Lun-Xiu Qin Hui-Chuan Sun Qing-Hai Ye 349

20 Molecular Pathogenesis of Hepatocellular Carcinoma Chun Ming Wong Judy Wai Ping Yam Irene O.L. Ng 373

Subject Index 397