Molecular Genetics of Mycobacteria / Edition 2 available in Hardcover, eBook
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Molecular Genetics of Mycobacteria / Edition 2
- ISBN-10:
- 1555818838
- ISBN-13:
- 9781555818838
- Pub. Date:
- 09/17/2014
- Publisher:
- Wiley
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Molecular Genetics of Mycobacteria / Edition 2
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Overview
Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today.
Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge.
Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition,
- Discusses key areas of current research in mycobacterial genetics
- Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis
- Presents genetic approaches for manipulating M. tuberculosis
This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.
Table of Contents
Contributors ixPreface xvii
I. Genomes, Genomics, and Genetic Exchange
1. Gene Transfer in Mycobacterium tuberculosis: Shuttle Phasmids to Enlightenment 3William R. Jacobs, Jr.
2. Mycobacterial Pathogenomics and Evolution 27Daria Bottai, Timothy P. Stinear, Philip Supply, and Roland Brosch
3. BCG Vaccines 49Vanessa Tran, Jun Liu, and Marcel A. Behr
4. Distributive Conjugal Transfer: New Insights into Horizontal Gene Transfer and Genetic Exchange in Mycobacteria 61Keith M. Derbyshire and Todd A. Gray
5. Molecular Genetics of Mycobacteriophages 81Graham F. Hatfull
6. Genetics of Phage Lysis 121Madalena Pimentel
Ii. Gene Expression and Regulation
7. Sigma Factors: Key Molecules in Mycobacterium tuberculosis Physiology and Virulence 137Riccardo Manganelli
8. Transcription Factor Binding Site Mapping Using ChIP-Seq 161Suma Jaini, Anna Lyubetskaya, Antonio Gomes, Matthew Peterson, Sang Tae Park, Sahadevan Raman, Gary Schoolnik, and James Galagan
9. Noncoding RNA in Mycobacteria 183Kristine B. Arnvig, Teresa Cortes, and Douglas B. Young
10. Two-Component Regulatory Systems of Mycobacteria 209Tanya Parish
11. Regulated Expression Systems for Mycobacteria and Their Applications 225Dirk Schnappinger and Sabine Ehrt
Iii. The Mycobacterial Proteome
12. Mycobacterium tuberculosis in the Proteomics Era 241Martin Gengenbacher, Jeppe Mouritsen, Olga T. Schubert, Ruedi Aebersold, and Stefan H. E. Kaufmann
13. Structural Annotation of the Mycobacterium tuberculosis Proteome 261Nagasuma Chandra, Sankaran Sandhya, and Praveen Anand
14. Cyclic AMP Signaling in Mycobacteria 281Gwendowlyn S. Knapp and Kathleen A. McDonough
IV. Metabolism
15. The Physiology and Genetics of Oxidative Stress in Mycobacteria 299Bridgette M. Cumming, Dirk Lamprecht, Ryan M. Wells, Vikram Saini, James H. Mazorodze, and Adrie J. C. Steyn
16. Metabolomics of Central Carbon Metabolism in Mycobacterium tuberculosis 323Anthony D. Baughn and Kyu Y. Rhee
17. Mycobacterial Lipidomics 341Emilie Layre, Reem Al-Mubarak, John T. Belisle, and D. Branch Moody
18. Genetics of Mycobacterial Trehalose Metabolism 361Rainer Kalscheuer and Hendrik Koliwer-Brandl
19. Metallobiology of Tuberculosis 377G. Marcela Rodriguez and Olivier Neyrolles
20. Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria 389Gregory M. Cook, Kiel Hards, Catherine Vilcheze, Travis Hartman, and Michael Berney
V. Genetics of Drug Resistance
21. Molecular Basis of Drug Resistance in Mycobacterium tuberculosis 413Keira A. Cohen, William R. Bishai, and Alexander S. Pym
22. Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities 431Catherine Vilcheze and William R. Jacobs, Jr.
23. The Molecular Genetics of Fluoroquinolone Resistance in Mycobacterium tuberculosis 455Claudine Mayer and Howard Takiff
24. Mechanisms of Pyrazinamide Action and Resistance 479Ying Zhang, Wanliang Shi, Wenhong Zhang, and Denis Mitchison
25. Genetic Strategies for Identifying New Drug Targets 493Andrej Trauner, Christopher M. Sassetti, and Eric J. Rubin
VI. Genetics of Membrane and Cell Wall Biosynthesis
26. Genetics of Peptidoglycan Biosynthesis 513Martin S. Pavelka, Jr., Sebabrata Mahapatra, and Dean C. Crick
27. Genetics of Mycobacterial Arabinogalactan and Lipoarabinomannan Assembly 535Monika Jankute, Shipra Grover, Helen L. Birch, and Gurdyal S. Besra
28. Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids 559Mamadou Daffe, Dean C. Crick, and Mary Jackson
29. The Molecular Genetics of Mycolic Acid Biosynthesis 611Jakub Pawełczyk and Laurent Kremer
VII. Genetics of Macromolecular Biosynthesis
30. Nucleotide Metabolism and DNA Replication 635Digby F. Warner, Joanna C. Evans, and Valerie Mizrahi
31. Double-Strand DNA Break Repair in Mycobacteria 657Michael S. Glickman
32. The Pup-Proteasome System of Mycobacteria 667Nadine J. Bode and K. Heran Darwin
33. Mycobacterium tuberculosis Serine/Threonine Protein Kinases 681Sladjana Prisic and Robert N. Husson
VIII. The Mycobacterial Lifestyle, Persistence, and Macrophage Survival
34. The Spectrum of Drug Susceptibility in Mycobacteria 711Bree B. Aldridge, Iris Keren, and Sarah M. Fortune
35. The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell–Derived Pressures 727David G. Russell, Wonsik Lee, Shumin Tan, Neelima Sukumar, Maria Podinovskaia, Ruth J. Fahey, and Brian C. VanderVen
36. Evasion of Innate and Adaptive Immunity by Mycobacterium tuberculosis 747Michael F. Goldberg, Neeraj K. Saini, and Steven A. Porcelli
37. Mycobacterial Biofilms 773Jacobs P. Richards and Anil K. Ojha
Index 785