Molecular Specialization and Symmetry in Membrane Function

by Arthur K. Solomon (Editor), Manfred Karnovsky (Editor)

Overview

Biological membranes have been under intensive investigation for several decades. Despite very great experimental challenges, membranes are at last beginning to reveal their secrets. In this book, leading investigators of membrane structure and function report on progress in three related fields: specialization of membrane regions, asymmetry in transport properties, and differentiation of cell faces in epithelia.

"Specialization at the Molecular Level" is the subject of the first section; in it, the authors consider such problems as the biogenesis of membranes, the geometry of protein-lipid relationships, and the physical properties of membrane receptor-sites. In the second section, "Asymmetry in Transport," such topics as the sodium-potassium pump, proton translocation, and anion transport are covered. The last section is entitled "Polar Faces in Epithelia" and deals with the complex properties of ion transport across the complex membrane environment maintained by surfaces such as the renal tubular epithelia.

Product Details

ISBN-13:	9780674367210
Publisher:	Harvard University Press
Publication date:	02/05/1978
Series:	Harvard Books in Biophysics , #2
Edition description:	Reprint 2014
Pages:	351
Product dimensions:	6.10(w) x 9.06(h) x (d)

About the Author

Solomon Arthur K. :

Arthur K. Solomon is Professor of Biophysics at the Harvard Medical SchoolKarnovsky Manfred :

Manfred Karnovsky is Harold I. White Professor of Biological Chemistry, at the Harvard Medical School

Table of Contents

Part One: Specialization at the Molecular Level

1. Membrane Biogenesis

George E. Palade

2. Lipid-Protein Associations

O. Hayes Griffith and Patricia C. Jost

3. Molecular Architecture of Oligomeric Membrane Proteins

Fernando Cabral, Walter Birchmeier, Carmen E. Kohler, and Gottfried Schatz

4. Transmembrane Compositional Asymmetry of Lipids in Bilayers and Biomembranes

Thomas E. Thompson

5. Ligand-Binding Properties of Membrane-Bound Cholinergic Receptors of Torpedo Marmorata

Jonathan B. Cohen

6. The Functional Roles of Band 3 Protein of the Red Blood Cell

Aser Rothstein

7. Energetics and Molecular Biology of Membrane Transport

H. R. Kaback, S. Ramos, D. F. Robertson, P. Stroobant, and H. Tokuda

Part Two: Asymmetry in Transport

8. Asymmetry and the Mechanism of the Red Cell Na-K Pump, Determined by Ouabain Binding

Joseph F. Hoffman

9. Simultaneous or Consecutive Occupancy by Sodium and Potassium Ions of Their Membrane Pump

Robert L. Post

10. Proton Translocation in Submitochondrial Particles and Reconstituted Segments of the Respiratory Chain

Peter C. Hinkle

11. Studies on the Molecular Mechanism of Anion Transport across the Red Blood Cell Membrane

Hermann Passow and Laila Zaki

Part Three: Polar Faces in Epithelia

12. The Double-Membrane Model for Transepithelial Ion Transport: Are Homocellular and Transcellular Ion Transport Related?

Stanley G. Schultz

13. Differentiation of Cell Faces in Epithelia

R. Kinne and E. Kinne-Saffran

14. Solute-Coupled Water Transport in the Kidney

Emile L. Boulpaep

15. Modes of Sodium Transport in the Kidney

Guillermo Whittembury, Madalina Condrescu-Guidi, Margarita Perez-Gonzalez De La Manna, and F. Proverbio

Index