Molecules: Nucleation, Aggregation And Crystallization: Beyond Medical And Other Implications

by Paolo Riccio, Jan Sedzik

Overview

This volume, dealing with Nucleation, Aggregation and Crystallization, consists of a compilation of lectures offered at the international course held at Karolinska Institute and at the scientific meetings of the MARIE Network.The word “nucleation,” derived from “nuclear family,” refers to the concept of the progenitor, or the mother and the father of any family. Only in the last few centuries have physicists “borrowed” the word, and more recently, biologists for Theodor Schwann's cell theory. Most recently, the term has come into use in atomic theory, spectroscopy, and radioactivity, as well as in the fields of atomic bombs, fission, and fusion. Nucleation as a physicochemical process is followed by two poorly understood phenomena — aggregation and crystallization - which underlie disorders like Alzheimer's and “mad-cow” disease (aggregation of amyloid plaque), cardiovascular diseases (deposition in coronary vessels of cholesterol and lipids), and the appearance of crystals under physiological conditions (gout, silicoses, and liver or kidney stones).Written by leading scientists in the field, including one Nobel Laureate, this book provides a unique perspective between the physical and chemical sciences on the one hand, and the biological and medical sciences on the other, and should be of considerable value to scientists, physicians, students, and the interested lay public.

Product Details

ISBN-13:	9789812832658
Publisher:	World Scientific Publishing Company, Incorporated
Publication date:	05/05/2009
Pages:	364
Product dimensions:	6.00(w) x 8.90(h) x 0.60(d)

Table of Contents

Preface v

1 From Kuru to Nucleation, Aggregation, Polymerization and Crystallization in Biology and Medicine D. Carleton Gajdusek 1

2 Gels Mimicking Antibodies in Their Selective Recognition of Proteins and Its Potential Use for Protein Crystallization Jan Sedzik Nasim Ghasemzadeh Fred Nyberg Stellan Hjertén 11

3 Bioinformatics of Myelin Membrane Proteins Gunnar von Heijne Jan Sedzik 35

4 Biomolecular Mass Spectrometry: Applications to Proteins and Peptides Leopold L. Ilag Gianluca Maddalo 55

5 Myelin: A One-Dimensional Biological "Crystal" for X-Ray and Neutron Scattering Hideyo Inouye Daniel A. Kirschner 75

6 Two-Dimensional Crystallization of Biological Macromolecules Hans Hebert 95

7 Crystallization of Proteins: Principles and Methods Lata Govada 113

8 The Role of Oil in Protein Crystallization Naomi E. Chayen 129

9 Introduction to Crystallization of Fine Chemicals and Pharmaceuticals Åke C. Rasmuson 145

10 Myelin Basic Protein, A Saucy Molecule With High Responsiveness to the Environment or Just an Unusual Membrane Protein? Paolo Riccio 173

11 The Use of a Magnetic Field and Magnetic Force as a Means to Improve the Quality of Protein Crystals Mitsuo Ataka 195

12 Interactive Crystallomic Jan Sedzik 225

13 Virtual Molecule: P0 Myelin Glycoprotein. I. Homology Modeling and Prediction of the Secondary and Tertiary Structure Jan Pawel Jastrzebski Jan Sedzik 237

14 In meso Approaches to Membrane Protein Crystallization Valentin I. Gordeliy Ekaterina S. Moiseeva 259

15 Amyloid, The Amyloid β-Peptide and Alzheimer's Disease: Structural Considerations Lars O. Tjernberg 283

16 Recent Advances in Structural Basis forMolecular Mimicry in Inflammatory Autoimmune Demyelinating Polyneuropathy Xin Yang 305

17 Fresh Water Pearls of Wisdom on Protein Crystallization Jan Sedzik 331

Glossary 345

Index 349