Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease / Edition 1

by Alexander Sigalov

Overview

This book intends to assemble reviews on the progress in defining and controlling the spatiotemporal organization of key events in immune cell activation. Improved understanding of MIRR-mediated signaling has a number of potential practical applications, from the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes. In Section 1, spatial organization and physiological function of the MIRR family members such as T cell receptor (TCR), B cell receptor (BCR), Fc receptors, natural killer (NK) cell receptors, and platelet glycoprotein VI (GPVI) will be reviewed. Section 2 will focus on current models of MIRR-triggering and highlight modern technologies to visualize cell-cell interaction contacts such as immunological synapse and to measure protein-protein interactions in space in real time. Potential therapeutic strategies targeting the MIRR-mediated transmembrane signal transduction will be shortly reviewed in Section 3. This book will summarize our current knowledge in this field and illustrate how control of the MIRR-triggered signaling could become a potential target of medical intervention, thus bridging basic and clinical immunology.

Product Details

ISBN-13:	9780387097886
Publisher:	Springer New York
Publication date:	10/27/2008
Series:	Advances in Experimental Medicine and Biology , #640
Edition description:	2008
Pages:	357
Product dimensions:	6.80(w) x 10.20(h) x 1.00(d)

About the Author

ALEXANDER SIGALOV, PhD, is a Research Assistant Professor in the Department of Pathology at the University of Massachusetts Medical School in Worcester, Massachusetts, USA. His main research interests include protein intrinsic disorder and oligomericity in the context of transmembrane signal transduction, the molecular mechanisms underlying immune receptor-mediated signaling and ways to control these processes and thus to modulate the immune response, as well as the development and applications of novel targets and strategies for innovative immune therapy. He discovered and investigated a very unusual and unique biophysical phenomenon, the homooligomerization of intrinsically disordered proteins, thus providing the first evidence for the existence of specific interactions between unfolded protein molecules. In the field of immunology, he unraveled a long-standing mystery of transmembrane signaling and immune cell activation triggered by multichain immune recognition receptors. Later, he developed a novel concept of platelet inhibition and invented a novel class of platelet inhibitors. In the field of immune therapy, he proposed new therapeutic strategies for a variety of malignancies and immune disorders, including immunodeficiencies, inflammatory and autoimmune diseases, allergy and HIV. He is a member of the American Association for the Advancement of Science and the Biophysical Society, USA. Alexander Sigalov received his academic degrees (MSc in Chemistry and a PhD in Organic Chemistry) from Moscow State University, Russia.

Table of Contents

MIRRs: Structure and Physiological Function.- T-Cell Receptor.- B-Cell Receptor.- Fc Receptors.- Natural Killer Cell Receptors.- Platelet Glycoprotein VI.- MIRR Signaling: Possible Mechanisms and the Techniques to Study and Visualize.- Clustering Models.- Segregation Models.- Kinetic Proofreading Model.- Serial Triggering Model.- Conformational Model.- Permissive Geometry Model.- Signaling Chain Homooligomerization (SCHOOL) Model.- Visualization of Cell-Cell Interaction Contacts-Synapses and Kinapses.- Visualization of Protein Interactions in Living Cells.- MIRR Signaling and Therapy of Immune Disorders.- Immunogenicity in Peptide-Immunotherapy: From Self/Nonself to Similar/Dissimilar Sequences.- Therapeutic Application of Transmembrane T and Natural Killer Cell Receptor Peptides.- Fc Receptor Targeting in the Treatment of Allergy, Autoimmune Diseases and Cancer.- Therapeutic Blockade of T- Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease.- MHC and MHC-Like Molecules: Structural Perspectives on the Design of Molecular Vaccines.- SCHOOL Model and New Targeting Strategies.- Immune Receptor Signaling, Aging and Autoimmunity.- Viral Pathogenesis, Modulation of Immune Receptor Signaling and Treatment.